All Outputs (2)

Versatile selective evolutionary pressure using synthetic defect in universal metabolism (2021)
Journal Article
Sellés Vidal, L., Murray, J. W., & Heap, J. T. (2021). Versatile selective evolutionary pressure using synthetic defect in universal metabolism. Nature Communications, 12(1), Article 6859. https://doi.org/10.1038/s41467-021-27266-9

The non-natural needs of industrial applications often require new or improved enzymes. The structures and properties of enzymes are difficult to predict or design de novo. Instead, semi-rational approaches mimicking evolution entail diversification... Read More about Versatile selective evolutionary pressure using synthetic defect in universal metabolism.

Combinatorial assembly platform enabling engineering of genetically stable metabolic pathways in cyanobacteria (2021)
Journal Article
Taylor, G. M., Hitchcock, A., & Heap, J. T. (2021). Combinatorial assembly platform enabling engineering of genetically stable metabolic pathways in cyanobacteria. Nucleic Acids Research, 49(21), e123-e123. https://doi.org/10.1093/nar/gkab791

Cyanobacteria are simple, efficient, genetically-tractable photosynthetic microorganisms which in principle represent ideal biocatalysts for CO2 capture and conversion. However, in practice, genetic instability and low productivity are key, linked pr... Read More about Combinatorial assembly platform enabling engineering of genetically stable metabolic pathways in cyanobacteria.