All Outputs (4)

Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor (2020)
Journal Article
Gunera, J., Baker, J. G., van Hilten, N., Rosenbaum, D. M., & Kolb, P. (2020). Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor. Journal of Medicinal Chemistry, 63(19), 11045-11053. https://doi.org/10.1021/acs.jmedchem.0c00964

The orexin receptors are peptide-sensing G protein-coupled receptors that are intimately linked with regulation of the sleep/wake cycle. We used a recently solved X-ray structure of the orexin receptor subtype 2 in computational docking calculations... Read More about Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor.

Using Esterase Selectivity to Determine the in Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical ?-Blockers (2020)
Journal Article
Baker, J. G., Fromont, C., Bruder, M., Thompson, K. S., Kellam, B., Hill, S. J., …Fischer, P. M. (2020). Using Esterase Selectivity to Determine the in Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical β-Blockers. ACS Pharmacology & Translational Science, 3(4), 737-748. https://doi.org/10.1021/acsptsci.0c00051

© 2020 American Chemical Society. For disorders of the skin, eyes, ears, and respiratory tract, topical drugs, delivered directly to the target organ, are a therapeutic option. Compared with systemic oral therapy, the benefits of topical treatments i... Read More about Using Esterase Selectivity to Determine the in Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical ?-Blockers.

The affinity and selectivity of ?-adrenoceptor antagonists, antidepressants, and antipsychotics for the human ?1A, ?1B, and ?1D-adrenoceptors (2020)
Journal Article
Proudman, R. G. W., Pupo, A. S., & Baker, J. G. (2020). The affinity and selectivity of ?-adrenoceptor antagonists, antidepressants, and antipsychotics for the human ?1A, ?1B, and ?1D-adrenoceptors. Pharmacology Research and Perspectives, 8(4), https://doi.org/10.1002/prp2.602

© 2020 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. α1-adrenoceptor antagonists are widely used for hype... Read More about The affinity and selectivity of ?-adrenoceptor antagonists, antidepressants, and antipsychotics for the human ?1A, ?1B, and ?1D-adrenoceptors.

Case for continuing community NIV and CPAP during the COVID-19 epidemic (2020)
Journal Article
Baker, J. G., & Sovani, M. P. (2020). Case for continuing community NIV and CPAP during the COVID-19 epidemic. Thorax, 75(5), 368-368. https://doi.org/10.1136/thoraxjnl-2020-214913

Dear Editor, Recent clinical guidelines regarding the use of home non-invasive ventilation (NIV) and continuous positive airway pressure (CPAP) during the COVID-19 epidemic have tried to balance the risks of stopping NIV or CPAP against the unknown p... Read More about Case for continuing community NIV and CPAP during the COVID-19 epidemic.