All Outputs (2)

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy (2017)
Journal Article
Rossi, F., Geiszler, P. C., Meng, W., Barron, M., Prior, M., Herd-Smith, A., …Conforti, L. (2018). NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural Brain Research, 339, https://doi.org/10.1016/j.bbr.2017.11.030

NAD metabolism and the NAD biosynthetic enzymes nicotinamide nucleotide adenylyltransferases (NMNATs) are thought to play a key neuroprotective role in tauopathies, including Alzheimer’s disease. Here, we investigated whether modulating the expressio... Read More about NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.

Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice (2017)
Journal Article
Oyegbami, O., Collins, H. M., Pardon, M., Ebling, F. J., Heery, D. M., & Moran, P. M. (2017). Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice. Current Alzheimer Research, 14(8), 850-860. https://doi.org/10.2174/1567205014666170317113159

In addition to cognitive decline, Alzheimer’s disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as ‘sundowning’. These symptoms a... Read More about Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice.