Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture
(2016)
Journal Article
Lorenzi, F., Babaei-Jadidi, R., Sheard, J., Spencer-Dene, B., & Nateri, A. S. (2016). Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture. Molecular Therapy - Methods and Clinical Development, 3, 16024. https://doi.org/10.1038/mtm.2016.24
Colorectal cancer (CRC) is one of the top three cancer-related causes of death worldwide. FBXW7 is a known tumor-suppressor gene, commonly mutated in CRC and in a variety of other epithelial tumors. Low expression of FBXW7 is also associated with poo... Read More about Fbxw7-associated drug resistance is reversed by induction of terminal differentiation in murine intestinal organoid culture.