All Outputs (2)

Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice (2016)
Journal Article
Hiorns, J. E., Bidan, C. M., Jensen, O. E., Gosens, R., Kistemaker, L. E., Fredberg, J. J., …Brook, B. S. (2016). Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Frontiers in Physiology, 7(JUL), Article 309. https://doi.org/10.3389/fphys.2016.00309

The precision-cut lung slice (PCLS) is a powerful tool for studying airway reactivity, but biomechanical measurements to date have largely focused on changes in airway caliber. Here we describe an image processing tool that reveals the associated spa... Read More about Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice.

Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall (2016)
Journal Article
Hiorns, J. E., Jensen, O. E., & Brook, B. S. (2016). Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall. Journal of Applied Physiology, 121(1), 233-247. https://doi.org/10.1152/japplphysiol.00715.2015

Airway hyperresponsiveness (AHR) is a key characteristic of asthma that remains poorly understood. Tidal breathing and deep inspiration ordinarily cause rapid relaxation of airway smooth muscle (ASM) (as demonstrated via application of length fluctua... Read More about Static and dynamic stress heterogeneity in a multiscale model of the asthmatic airway wall.