All Outputs (3676)

DNA damage repair in breast cancer and its therapeutic implications (2016)
Journal Article

The DNA damage response (DDR) involves the activation of numerous cellular activities that repair DNA lesions and maintain genomic integrity, and is critical in preventing tumorigenesis. Inherited or acquired mutations in specific genes involved in t... Read More about DNA damage repair in breast cancer and its therapeutic implications.

Therapeutic implications of counselling psychologists’ responses to client trauma: an interpretative phenomenological analysis (2016)
Journal Article

The past two decades have seen a surge of interest in the impact of working with trauma survivors on therapists’ psychological well-being. Existing literature assumes that therapists’ strong subjective responses to traumatic material adversely influe... Read More about Therapeutic implications of counselling psychologists’ responses to client trauma: an interpretative phenomenological analysis.

VALES. II. The physical conditions of interstellar gas in normal star-forming galaxies up to z=0.2 revealed by ALMA (2016)
Journal Article

We use new Band 3 CO(1–0) observations taken with the Atacama Large Millimeter/submillimeter Array (ALMA) to study the physical conditions in the interstellar gas of a sample of 27 dusty main-sequence star-forming galaxies at 0:03 < z < 0:2 present i... Read More about VALES. II. The physical conditions of interstellar gas in normal star-forming galaxies up to z=0.2 revealed by ALMA.

Analysis of a hysteresis-controlled self-oscillating class-D amplifier (2016)
Journal Article

This paper gives the first systematic perturbation analysis of the audio distortion and mean switching period for a self-oscillating class-D amplifier. Explicit expressions are given for all the principal components of audio distortion, for a general... Read More about Analysis of a hysteresis-controlled self-oscillating class-D amplifier.

A monomeric, heterobimetallic complex with an unsupported Mg−Fe bond (2016)
Journal Article

The phosphinimine, trimethylsilyl-substituted BIPM ligand [BIPM = bis(iminophosphorano)methanide] has been used to stabilise CH(Ph2PNSiMe3)2MgFe(η5-C5H5)(CO)2 (1), which is a structurally authenticated complex exhibiting a direct, unsupported bond be... Read More about A monomeric, heterobimetallic complex with an unsupported Mg−Fe bond.

Multiple genetic associations with Irish wolfhound dilated cardiomyopathy (2016)
Journal Article

Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of the most commonly affected breeds and one of the few breeds with gene... Read More about Multiple genetic associations with Irish wolfhound dilated cardiomyopathy.

Dynamic programming with approximation function for nurse scheduling (2016)
Journal Article

Although dynamic programming could ideally solve any combinatorial optimization problem, the curse of dimensionality of the search space seriously limits its application to large optimization problems. For example, only few papers in the literature h... Read More about Dynamic programming with approximation function for nurse scheduling.

Detection of the delayed condensation effect and determination of its impact on the accuracy of gas adsorption pore size distributions (2016)
Journal Article

Macroscopic, highly disordered, mesoporous materials present a continuing challenge for accurate pore structure characterization. The typical macroscopic variation in local average pore space descriptors means that methods capable of delivering stati... Read More about Detection of the delayed condensation effect and determination of its impact on the accuracy of gas adsorption pore size distributions.

The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink (2016)
Journal Article

Objectives: To estimate the incidence, prevalence and mortality of Granulomatosis with polyangiitis (GPA) in the United Kingdom. Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Epi... Read More about The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink.

A hybrid finite element and surrogate modelling approach for simulation and monitoring supported TBM steering (2016)
Journal Article

The paper proposes a novel computational method for real-time simulation and monitoring-based predictions during the construction of machine-driven tunnels to support decisions concerning the steering of tunnel boring machines (TBMs). The proposed te... Read More about A hybrid finite element and surrogate modelling approach for simulation and monitoring supported TBM steering.

Effect of possible rotor deformation on the probability of face contact for a liquid film bearing (2016)
Journal Article

The possibility of face contact is examined for a coaxial rotor-stator bearing in dynamic motion constrained by a highly rotating very thin liquid film. A modified Reynolds equation for pressurised flow is coupled to the bearing structure leading to... Read More about Effect of possible rotor deformation on the probability of face contact for a liquid film bearing.

Regularized inner products and errors of modularity (2016)
Journal Article

© The Author(s) 2016. We develop a regularization for Petersson inner products of arbitrary weakly holomorphic modular forms, generalizing several known regularizations. As one application, we extend work of Duke, Imamoglu, and Toth on regularized in... Read More about Regularized inner products and errors of modularity.

Exposure to a maternal cafeteria diet changes open-field behaviour in the developing offspring (2016)
Journal Article

The early postnatal period is a sensitive period in rodents as behavioural systems are developing and maturing during this time. However, little is currently known about the behavioural effects of feeding a hyper-energetic cafeteria diet (CD) during... Read More about Exposure to a maternal cafeteria diet changes open-field behaviour in the developing offspring.

Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: a Bayesian meta-analysis of survival data (2016)
Journal Article

Aim: To conduct a systematic review and meta-analysis to determine the risk of cardiovascular events and all-cause mortality associated with sulphonylureas (SUs) vs other glucose lowering drugs in patients with T2DM (T2DM. Materials and methods: A s... Read More about Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: a Bayesian meta-analysis of survival data.

The emergence of waves in random discrete systems (2016)
Journal Article

Essential criteria for the emergence of wave-like manifestations occurring in an entirely discrete system are identified using a simple model for the movement of particles through a network. The dynamics are entirely stochastic and memoryless involvi... Read More about The emergence of waves in random discrete systems.

The direct-to-indirect band gap crossover in two-dimensional van der Waals Indium Selenide crystals (2016)
Journal Article

The electronic band structure of van der Waals (vdW) layered crystals has properties that depend on the composition, thickness and stacking of the component layers. Here we use density functional theory and high field magneto-optics to investigate th... Read More about The direct-to-indirect band gap crossover in two-dimensional van der Waals Indium Selenide crystals.

Experimental and numerical investigation of footing behaviour on multi-layered rubber-reinforced soil (2016)
Journal Article

This paper describes the beneficial effects of multiple layers of rubber–sand mixture (RSM). The plate load tests, using circular plate of 300 mm diameter, were performed at an outdoor test pit, dug in natural ground with dimensions of 2000 × 2000 mm... Read More about Experimental and numerical investigation of footing behaviour on multi-layered rubber-reinforced soil.

Propagating wave correlations in complex systems (2016)
Journal Article

We describe a novel approach for computing wave correlation functions inside finite spatial domains driven by complex and statistical sources. By exploiting semiclassical approximations, we provide explicit algorithms to calculate the local mean of t... Read More about Propagating wave correlations in complex systems.

The impact of electrode resistance on the biogalvanic characterisation technique (2016)
Journal Article

Measurement of a tissue-specific electrical resistance may offer a discriminatory metric for evaluation of tissue health during cancer surgery. With a move toward minimally-invasive procedures, applicable contact sensing modalities must be scalable,... Read More about The impact of electrode resistance on the biogalvanic characterisation technique.

Potential pitfalls when denoising resting state fMRI data using nuisance regression (2016)
Journal Article

In resting state fMRI, it is necessary to remove signal variance associated with noise sources, leaving cleaned fMRI time-series that more accurately reflect the underlying intrinsic brain fluctuations of interest. This is commonly achieved through n... Read More about Potential pitfalls when denoising resting state fMRI data using nuisance regression.