All Outputs (2)

Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins (2015)
Journal Article
Charlton, S. J., Blakeley, D., Sykes, D. A., Ensor, P., Bertran, E., Aston, P. J., & Charlton, S. J. (2015). Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins. British Journal of Pharmacology, 172(21), 5037-5049. https://doi.org/10.1111/bph.13263

© 2015 The British Pharmacological Society. Background and Purpose Plasma protein binding (PPB) influences the free fraction of drug available to bind to its target and is therefore an important consideration in drug discovery. While traditional meth... Read More about Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins.

Functional desensitization of the ? 2 adrenoceptor is not dependent on agonist efficacy (2015)
Journal Article
Rosethorne, E. M., Bradley, M. E., Kent, T. C., & Charlton, S. J. (2015). Functional desensitization of the ? 2 adrenoceptor is not dependent on agonist efficacy. Pharmacology Research and Perspectives, 3(1), https://doi.org/10.1002/prp2.101

© 2015 John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. Chronic treatment with β2 adrenoceptor agonists is recommended as a first-line maintenance therapy for chronic obstru... Read More about Functional desensitization of the ? 2 adrenoceptor is not dependent on agonist efficacy.