All Outputs (2431)

Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor (2014)
Journal Article

The Aryl hydrocarbon receptor (AhR) binds a variety of chlorinated and brominated dioxins, furans and biphenyls. Mixed halogenated variants have been recently identified in food at significant levels but full characterisation requires potency data in... Read More about Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

From publics to practitioners: invention power and open technoscience (2014)
Journal Article

There are more publics involved in science than one would imagine at first sight. In technoscientific conditions what counts as knowledge creation is not primarily the individual experimental achievement that gives coherence to scientific practice an... Read More about From publics to practitioners: invention power and open technoscience.

The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles (2014)
Journal Article

Aging is associated with a gradual loss of skeletal muscle mass and an impaired ability of this tissue to compensate for trauma. Studies in rodents and humans have also shown that resident stem cells within muscle have a reduced ability to proliferat... Read More about The effects of age upon the expression of three miRNAs in muscle stem cells isolated from two different porcine skeletal muscles.

Jómsvíkinga Sǫgur and Jómsvíkinga Drápur: texts, contexts and intertexts (2014)
Journal Article

Using theories of intertextuality the paper explores the implications of the complex transmission of Jómsvíkinga saga, with its multiple manuscripts, versions and cross-references in other texts. It then concentrates on the story-complex about the Jó... Read More about Jómsvíkinga Sǫgur and Jómsvíkinga Drápur: texts, contexts and intertexts.

Parallels, prescience and the past: analogical reasoning and contemporary international politics (2014)
Journal Article

Analogical reasoning has held a perpetual appeal to policymakers who have often drafted in historical metaphor as a mode of informing decision-making. However, this article contends that since the beginning of the ‘War on Terror’ we have arguably see... Read More about Parallels, prescience and the past: analogical reasoning and contemporary international politics.

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation (2014)
Journal Article

Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associated with cancer progression. Here, we demonstrate that the transcription factor TAp73 opposes HIF-1 activity through a nontranscriptional mechanism, thus affecting tumor angio... Read More about TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation.

Detection and quantification of allosteric modulation of endogenous M4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line (2014)
Journal Article

© 2014 Society for Laboratory Automation and Screening. Allosteric modulators of G protein-coupled receptors have the potential to achieve greater receptor subtype selectivity compared with ligands targeting the orthosteric site of this receptor fami... Read More about Detection and quantification of allosteric modulation of endogenous M4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line.

High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity (2014)
Journal Article

Aims Encapsulated papillary carcinoma (EPC) is a recognized special type of breast carcinoma. Despite compelling evidence indicating its invasive nature, although not of a conventional form, the current consensus is to manage EPC as an in?situ disea... Read More about High-grade encapsulated papillary carcinoma of the breast: an under-recognized entity.

Priming memories of past wins induces risk seeking (2014)
Journal Article

People are often risk averse when making decisions under uncertainty. When those decisions are based on past experience, people necessarily rely on their memories. Thus, what is remembered at the time of the choice should influence risky choice. We t... Read More about Priming memories of past wins induces risk seeking.

Patterns of genome evolution that have accompanied host adaptation in Salmonella (2014)
Journal Article

Many bacterial pathogens are specialized, infecting one or few hosts, and this is often associated with more acute disease presentation. Specific genomes show markers of this specialization, which often reflect a balance between gene acquisition and... Read More about Patterns of genome evolution that have accompanied host adaptation in Salmonella.

Spatial complementarity and the coexistence of species (2014)
Journal Article

© 2014 Velázquez et al. Coexistence of apparently similar species remains an enduring paradox in ecology. Spatial structure has been predicted to enable coexistence even when population-level models predict competitive exclusion if it causes each spe... Read More about Spatial complementarity and the coexistence of species.

Calculation of the vibrational frequencies of carbon clusters and fullerenes with empirical potentials (2014)
Journal Article

© the Owner Societies 2015. Vibrational frequencies for carbon clusters, fullerenes and nanotubes evaluated using empirical carbon-carbon potentials are presented. For linear and cyclic clusters, frequencies evaluated with the reactive empirical bond... Read More about Calculation of the vibrational frequencies of carbon clusters and fullerenes with empirical potentials.

Biological and clinical significance of PARP1 protein expression in breast cancer (2014)
Journal Article

Poly(ADP-ribose) polymerase-1 (PARP1) is a key facilitator of DNA repair. PARP inhibitors have gained recent attention as promising therapeutic agents for the treatment of solid tumours including breast cancer (BC). However, the biological and clinic... Read More about Biological and clinical significance of PARP1 protein expression in breast cancer.

Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases (2014)
Journal Article

Type I modular polyketide synthases (PKSs), responsible for the biosynthesis of many biologically active agents, possess a ketosynthase (KS) domain within each module to catalyze chain elongation. Acylation of the KS active site Cys residue is foll... Read More about Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases.

Convergent genetic and expression data implicate immunity in Alzheimer's disease (2014)
Journal Article

© 2015, Elsevier Inc. All rights reserved. Background: Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underly... Read More about Convergent genetic and expression data implicate immunity in Alzheimer's disease.

Measuring sub-mm structural displacements using QDaedalus: a digital clip-on measuring system developed for total stations (2014)
Journal Article

The monitoring of rigid structures of modal frequencies greater than 5 Hz and sub-mm displacement is mainly based so far on relative quantities from accelerometers, strain gauges etc. Additionally geodetic techniques such as GPS and Robotic Total Sta... Read More about Measuring sub-mm structural displacements using QDaedalus: a digital clip-on measuring system developed for total stations.

Improving identification of familial hypercholesterolaemia in primary care: Derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT) (2014)
Journal Article

Objective: Heterozygous familial hypercholesterolaemia (FH) is a common autosomal dominant disorder. The vast majority of affected individuals remain undiagnosed, resulting in lost opportunities for preventing premature heart disease. Better use of r... Read More about Improving identification of familial hypercholesterolaemia in primary care: Derivation and validation of the familial hypercholesterolaemia case ascertainment tool (FAMCAT).

“You can’t just jump on a bike and go”: a qualitative study exploring parents’ perceptions of physical activity in children with type 1 diabetes (2014)
Journal Article

Background Parents of children with Type 1 Diabetes Mellitus (T1DM) have an important role in supporting diabetes management behaviours and helping to maintain their child’s healthy lifestyle. Physical activity has known benefits for children with... Read More about “You can’t just jump on a bike and go”: a qualitative study exploring parents’ perceptions of physical activity in children with type 1 diabetes.

Effects of bowel cleansing on the intestinal microbiota (2014)
Journal Article

Objective: An adequate bowel cleansing is essential for a successful colonoscopy. Although purgative consumption is safe for the patient, there is little consensus on how the intestinal microbiota is affected by the procedure, especially regarding th... Read More about Effects of bowel cleansing on the intestinal microbiota.

Influenza promotes collagen deposition via ?v?6 integrin-mediated transforming growth factor ? activation. (2014)
Journal Article