Skip to main content

Research Repository

Advanced Search

All Outputs (408)

The benefits of quantifying climate model uncertainty in climate change impacts assessment: An example with heat-related mortality change estimates (2011)
Journal Article
Gosling, S. N., McGregor, G. R., & Lowe, J. A. (2012). The benefits of quantifying climate model uncertainty in climate change impacts assessment: An example with heat-related mortality change estimates. Climatic Change, 112(2), 217-231. https://doi.org/10.1007/s10584-011-0211-9

The majority of climate change impacts assessments account for climate change uncertainty by adopting the scenario-based approach. This typically involves assessing the impacts for a small number of emissions scenarios but neglecting the role of clim... Read More about The benefits of quantifying climate model uncertainty in climate change impacts assessment: An example with heat-related mortality change estimates.

The genetics of pre-eclampsia and other hypertensive disorders of pregnancy (2011)
Journal Article
Williams, P. J., & Broughton Pipkin, F. (2011). The genetics of pre-eclampsia and other hypertensive disorders of pregnancy. Best Practice and Research: Clinical Obstetrics and Gynaecology, 25(4), https://doi.org/10.1016/j.bpobgyn.2011.02.007

Hypertension is the most frequent medical complication occurring during pregnancy. In this chapter, we aim to address the genetic contribution to these disorders, with specific focus on preeclampsia. The pathogenic mechanisms underlying pre-eclampsia... Read More about The genetics of pre-eclampsia and other hypertensive disorders of pregnancy.

A "non-parametric" version of the naive Bayes classifier (2011)
Journal Article
Soria, D., Garibaldi, J. M., Ambrogi, F., Biganzoli, E. M., & Ellis, I. O. (2011). A "non-parametric" version of the naive Bayes classifier. Knowledge-Based Systems, 24(6), https://doi.org/10.1016/j.knosys.2011.02.014

Many algorithms have been proposed for the machine learning task of classication. One of the simplest methods, the naive Bayes classifyer, has often been found to give good performance despite the fact that its underlying assumptions (of independence... Read More about A "non-parametric" version of the naive Bayes classifier.

Dynamics of DNA replication in yeast (2011)
Journal Article
Retkute, R., Nieduszynski, C. A., & Moura, A. D. (2011). Dynamics of DNA replication in yeast. Physical Review Letters, 107, Article 068103. https://doi.org/10.1103/PhysRevLett.107.068103

We present a mathematical model for the spatial dynamics of DNA replication. Using this model we determine the probability distribution for the time at which each chromosomal position is replicated. From this we show, contrary to previous reports, th... Read More about Dynamics of DNA replication in yeast.

Impulsivity and symptoms of nicotine dependence in a young adult population (2011)
Journal Article
Chase, H. W., & Hogarth, L. (2011). Impulsivity and symptoms of nicotine dependence in a young adult population. Nicotine & Tobacco Research, 13(12), https://doi.org/10.1093/ntr/ntr114

Introduction: Impulsivity is widely regarded as a risk factor for drug dependence. However, its relationship with the symptomatology of nicotine dependence is poorly understood. Methods: To examine the nature of these relationships, we recru... Read More about Impulsivity and symptoms of nicotine dependence in a young adult population.

The importance of antioxidant micronutrients and vitamins in pregnancy (2011)
Journal Article
Mistry, H. D., & Williams, P. J. (2011). The importance of antioxidant micronutrients and vitamins in pregnancy. Oxidative Medicine and Cellular Longevity, 2011, https://doi.org/10.1155/2011/841749

Pregnancy places increased demands on the mother to provide not only adequate nutrition to support her own health but also to enable the growth and development of the conceptus. A key role of a number of micronutrients and vitamins is their function... Read More about The importance of antioxidant micronutrients and vitamins in pregnancy.

Selenium in reproduction (2011)
Journal Article
Mistry, H. D., Broughton Pipkin, F., Redman, C. W., & Poston, L. (2012). Selenium in reproduction. American Journal of Obstetrics and Gynecology, 206(1), https://doi.org/10.1016/j.ajog.2011.07.034

Selenium is an essential trace element of importance to human biology and health. Increasing evidence suggests that this mineral plays an important role in normal growth and reproduction in animals and humans, and selenium supplementation is now reco... Read More about Selenium in reproduction.

“Frank Lloyd Oop”: microserfs, modern migration, and the architecture of the nineties (2011)
Journal Article
Thompson, G. (in press). “Frank Lloyd Oop”: microserfs, modern migration, and the architecture of the nineties. Canadian Review of American Studies, 31(3), https://doi.org/10.3138/CRAS-s031-03-02

If the early development of the computing industry in America was marked by a preoccupation with hardware, as companies like UNIVAC, DEC, and IBM filled the nation’s corporate and government offices with mainframes, then a similar pre­occupation has... Read More about “Frank Lloyd Oop”: microserfs, modern migration, and the architecture of the nineties.

Abrasive wear behaviour of conventional and large-particle tungsten carbide-based cermet coatings as a function of abrasive size and type (2011)
Journal Article
Kamdi, Z., Shipway, P., Voisey, K., & Sturgeon, A. (2011). Abrasive wear behaviour of conventional and large-particle tungsten carbide-based cermet coatings as a function of abrasive size and type. Wear, 271(9-10), https://doi.org/10.1016/j.wear.2010.12.060

Abrasive wear behaviour of materials can be assessed using a wide variety of testing methods, and the relative performance of materials will tend to depend upon the testing procedure employed. In this work, two cermet type coatings have been examined... Read More about Abrasive wear behaviour of conventional and large-particle tungsten carbide-based cermet coatings as a function of abrasive size and type.

Validation of a microsimulation of the port of Dover (2011)
Journal Article
Roadknight, C., Aickelin, U., & Sherman, G. (in press). Validation of a microsimulation of the port of Dover. Journal of Computational Science, 3(1-2), https://doi.org/10.1016/j.jocs.2011.07.005

Modelling and simulating the traffic of heavily used but secure environments such as seaports and airports is of increasing importance. Errors made when simulating these environments can have long standing economic, social and environmental implicati... Read More about Validation of a microsimulation of the port of Dover.

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ (2011)
Journal Article
Begitt, A., Droescher, M., Knobeloch, K.-P., & Vinkemeier, U. (2011). SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood, 118(4), https://doi.org/10.1182/blood-2011-04-347930

The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation. This occurs both directly through decreasing STAT1 tyrosine phosphorylation and indir... Read More about SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.

The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles (2011)
Journal Article
Rufini, S., Lena, A. M., Cadot, B., Mele, S., Amelio, I., Terrinoni, A., …Candi, E. (2011). The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles. Biochemical Pharmacology, 82(10), 1262-1268. https://doi.org/10.1016/j.bcp.2011.07.087

The transcription factor p63 plays pivotal roles in epidermal barrier formation and in embryonic development. The protein structures of TAp63 and ΔNp63α isoforms include a C-terminal steril alpha-motif (SAM) involved in protein–protein interaction. I... Read More about The sterile alpha-motif (SAM) domain of p63 binds in vitro monoasialoganglioside (GM1) micelles.

Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris (2011)
Journal Article
Whyteside, G., Alcocer, M. J., Kumita, J. R., Dobson, C. M., Lazarou, M., Pleass, R. J., & Archer, D. B. (2011). Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris. PLoS ONE, 6(7), Article e22692. https://doi.org/10.1371/journal.pone.0022692

We have investigated the relationship between the stability and secreted yield of a series of mutational variants of human lysozyme (HuL) in Pichia pastoris. We show that genes directly involved in the unfolded protein response (UPR), ER-associated d... Read More about Native-state stability determines the extent of degradation relative to secretion of protein variants from Pichia pastoris.

Personality is of central concern to understand health: towards a theoretical model for health psychology (2011)
Journal Article
Eamonn, F. (2013). Personality is of central concern to understand health: towards a theoretical model for health psychology. Health Psychology Review, 7(Suppl1), S32-S70. https://doi.org/10.1080/17437199.2010.547985

This paper sets out the case that personality traits are central to health psychology. To achieve this, three aims need to be addressed. First, it is necessary to show that personality influences a broad range of health outcomes and mechanisms. Secon... Read More about Personality is of central concern to understand health: towards a theoretical model for health psychology.

Modelling electricity consumption in office buildings: an agent based approach (2011)
Journal Article
Zhang, T., Siebers, P.-O., & Aickelin, U. (2011). Modelling electricity consumption in office buildings: an agent based approach. Energy and Buildings, 43(10), https://doi.org/10.1016/j.enbuild.2011.07.007

In this paper, we develop an agent-based model which integrates four important elements, i.e. organisational energy management policies/regulations, energy management technologies, electric appliances and equipment, and human behaviour, to simulate t... Read More about Modelling electricity consumption in office buildings: an agent based approach.

Real-time fermions for baryogenesis simulations (2011)
Journal Article
Saffin, P. M., & Tranberg, A. (2011). Real-time fermions for baryogenesis simulations. Journal of High Energy Physics, 2011(7), https://doi.org/10.1007/JHEP07%282011%29066

We study how to numerically simulate quantum fermions out of thermal equilibrium, in the context of electroweak baryogenesis. We find that by combining the lattice implementation of Aarts and Smit [1] with the "low cost" fermions of Borsanyi and Hind... Read More about Real-time fermions for baryogenesis simulations.