All Outputs (404)

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 (2011)
Journal Article

LIMD1 is a tumour suppressor gene (TSG) down regulated in ?80% of lung cancers with loss also demonstrated in breast and head and neck squamous cell carcinomas. LIMD1 is also a candidate TSG in childhood acute lymphoblastic leukaemia. Mechanistically... Read More about PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.

Case management for people with long-term conditions: impact upon emergency admissions and associated length of stay (2011)
Journal Article

This paper describes findings from a study that evaluated the implementation and impact of case management for long-term conditions (CMLTC) in 10 primary care trusts (PCTs). Patients who have long-term conditions and complex health and social needs m... Read More about Case management for people with long-term conditions: impact upon emergency admissions and associated length of stay.

Rutting as a function of dynamic modulus and gradation (2011)
Journal Article

This study was conducted to investigate rutting resistance of asphalt concrete (AC) mixtures as a function of dynamic modulus and gradation. The Flow number (FN) test, the (NCHRP 9-19) recommended procedure for evaluating rutting resistance of AC mix... Read More about Rutting as a function of dynamic modulus and gradation.

Armed conflict and child health (2011)
Journal Article

Armed conflict has a major impact on child health throughout the world. One in six children worldwide lives in an area of armed conflict and civilians are more likely to die than soldiers as a result of the conflict. In stark contrast to the effe... Read More about Armed conflict and child health.

Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy (2011)
Journal Article

The calpain family, and their endogenous inhibitor calpastatin, has been implicated in cancer progression, and recent in vitro data have indicated a role in trastuzumab resistance. The aims of our study were to examine expression levels of calpastati... Read More about Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.

Children, young people and requests for police station legal advice: 25 years on from PACE (2011)
Journal Article

Informed by data extracted from 30,921 police electronic custody records, drawn from 44 police stations across four police force areas and including 5153 records of juveniles aged 10 to 17 years, this article examines the take-up of legal advice by c... Read More about Children, young people and requests for police station legal advice: 25 years on from PACE.

Cross-Cultural Similarities and Differences in Person-Body Reasoning: Experimental Evidence From the United Kingdom and Brazilian Amazon (2011)
Journal Article

We report the results of a cross‐cultural investigation of person‐body reasoning in the United Kingdom and northern Brazilian Amazon (Marajó Island). The study provides evidence that directly bears upon divergent theoretical claims in cognitive psych... Read More about Cross-Cultural Similarities and Differences in Person-Body Reasoning: Experimental Evidence From the United Kingdom and Brazilian Amazon.

Cloning of the repertoire of individual Plasmodium falciparum var genes using Transformation Associated Recombination (TAR) (2011)
Journal Article

One of the major virulence factors of the malaria causing parasite is the Plasmodium falciparum encoded erythrocyte membrane protein 1 (PfEMP1). It is translocated to It the membrane of infected erythrocytes and expressed from approximately 60 var ge... Read More about Cloning of the repertoire of individual Plasmodium falciparum var genes using Transformation Associated Recombination (TAR).

Negotiating sacred roles: A Sociological Exploration of Priests who Are Mothers (2011)
Journal Article

In 1992, in a historic move, the Church of England voted to allow women's ordination to priesthood and in 1994 the first women priests started to be ordained. Despite much research interest, the experiences of priests who are mothers to dependent chi... Read More about Negotiating sacred roles: A Sociological Exploration of Priests who Are Mothers.

Transcriptional Regulation of Inflammatory Genes Associated with Severe Asthma (2011)
Journal Article

The 10% of patients with the most severe asthma are responsible for a large part of healthcare expenditure and morbidity. Understanding the processes involved is key if new therapeutic approaches are to be developed. Evidence is accumulating that chr... Read More about Transcriptional Regulation of Inflammatory Genes Associated with Severe Asthma.

Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition (2011)
Journal Article

Latent inhibition (LI) manifests as poorer conditioning to a CS that has previously been presented without consequence. There is some evidence that LI can be potentiated by reduced mesoaccumbal dopamine (DA) function but the locus within the nucleus... Read More about Reduced dopamine function within the medial shell of the nucleus accumbens enhances latent inhibition.

International movement of prisoners (2011)
Journal Article

This article analyses and compares the evolution of the procedures and motivations for the international movement of prisoners under two systems operating in the United Kingdom – the inter-state prisoner transfer system and the international criminal... Read More about International movement of prisoners.

Involving older people in research: practical considerations when using the authenticity criteria in constructivist inquiry (2011)
Journal Article

Aim The purpose of this paper is to identify practical suggestions that could enable other researchers to consider how quality may be evidenced using constructivist principles including the perspectives of older people and their caregivers. Backg... Read More about Involving older people in research: practical considerations when using the authenticity criteria in constructivist inquiry.

Mathematical Modeling Predicts Synergistic Antitumor Effects of Combining a Macrophage-Based, Hypoxia-Targeted Gene Therapy with Chemotherapy (2011)
Journal Article

Perceiving text and image in Apollinaire's calligrammes (2011)
Journal Article

Literary scholars have recently become increasingly interested in the perceptual and cognitive mechanisms involved in reading, and have incorporated scientific research in this area into their critical approaches to texts. This article argues that su... Read More about Perceiving text and image in Apollinaire's calligrammes.

Virtual sensors for active noise control in acoustic–structural coupled enclosures using structural sensing: robust virtual sensor design (2011)
Journal Article

The work was aimed to develop a robust virtual sensing design methodology for sensing and active control applications of vibro-acoustic systems. The proposed virtual sensor was designed to estimate a broadband acoustic interior sound pressure using s... Read More about Virtual sensors for active noise control in acoustic–structural coupled enclosures using structural sensing: robust virtual sensor design.

Exploring transformative learning opportunities as part of the delivery of a video-based intervention (2011)
Journal Article

A teacher of the deaf reported a change in perspective following her involvement as a participant in a therapeutic intervention known as video interaction guidance (VIG). We applied a model of transformative learning to validate this report and to e... Read More about Exploring transformative learning opportunities as part of the delivery of a video-based intervention.

On Euclid’s algorithm and elementary number theory (2011)
Journal Article

Algorithms can be used to prove and to discover new theorems. This paper shows how algorithmic skills in general, and the notion of invariance in particular, can be used to derive many results from Euclid’s algorithm. We illustrate how to use the alg... Read More about On Euclid’s algorithm and elementary number theory.

The role of the user within the medical device design and development process: medical device manufacturers' perspectives (2011)
Journal Article

Background Academic literature and international standards bodies suggest that user involvement, via the incorporation of human factors engineering methods within the medical device design and development (MDDD) process, offer many benefits that e... Read More about The role of the user within the medical device design and development process: medical device manufacturers' perspectives.

Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters (2011)
Journal Article

We investigated whether histaminergic tone contributes to the seasonal catabolic state in Siberian hamsters by determining the effect of ablation of histaminergic neurons on food intake, metabolic rate and body weight. A ribosomal toxin (saporin) con... Read More about Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters.