All Outputs (37219)

A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks (2018)
Journal Article
Abeysuriya, R. G., Hadida, J., Sotiropoulos, S. N., Jbabdi, S., Becker, R., Hunt, B. A., …Woolrich, M. W. (in press). A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks. PLoS Computational Biology, 14(2), Article e1006007. https://doi.org/10.1371/journal.pcbi.1006007

Over long timescales, neuronal dynamics can be robust to quite large perturbations, such as changes in white matter connectivity and grey matter structure through processes including learning, aging, development and certain disease processes. One pos... Read More about A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks.

Limit-cycle oscillatory coexpression of cross-inhibitory transcription factors: a model mechanism for lineage promiscuity (2018)
Journal Article
Bokes, P., & King, J. R. (in press). Limit-cycle oscillatory coexpression of cross-inhibitory transcription factors: a model mechanism for lineage promiscuity. Mathematical Medicine and Biology, https://doi.org/10.1093/imammb/dqy003

Lineage switches are genetic regulatory motifs that govern and maintain the commitment of a developing cell to a particular cell fate. A canonical example of a lineage switch is the pair of transcription factors PU.1 and GATA-1, of which the former i... Read More about Limit-cycle oscillatory coexpression of cross-inhibitory transcription factors: a model mechanism for lineage promiscuity.

The Never-Ending Story: Discursive Legitimation in Social Media Dialogue (2018)
Journal Article
Glozer, S. A., Caruana, R., & Hibbert, S. (2019). The Never-Ending Story: Discursive Legitimation in Social Media Dialogue. Organization Studies, 40(5), 625-650. https://doi.org/10.1177/0170840617751006

© The Author(s) 2018. This paper explores the dialogical dimensions of discursive legitimation in social media sites to understand how organisations produce knowledge of legitimacy in concert with their stakeholders. Drawing on the dialogical theorie... Read More about The Never-Ending Story: Discursive Legitimation in Social Media Dialogue.

A comprehensive assessment of benign genetic variability for neurodegenerative disorders (2018)
Journal Article
Guerreiro, R., Sassi, C., Gibbs, J., Edsall, C., Hernandez, D., Brown, K., …Bras, J. (2018). A comprehensive assessment of benign genetic variability for neurodegenerative disorders. https://doi.org/10.1101/270686

Over the last few years, as more and more sequencing studies have been performed, it has become apparent that the identification of pathogenic mutations is, more often than not, a complex issue. Here, with a focus on neurodegenerative diseases, we ha... Read More about A comprehensive assessment of benign genetic variability for neurodegenerative disorders.

Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway (2018)
Journal Article
Herrod, P., & Lund, J. N. (in press). Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway. Techniques in Coloproctology, 22(2), https://doi.org/10.1007/s10151-018-1756-7

Background: Random duodenal biopsy to exclude coeliac disease during upper gastrointestinal endoscopy for the investigation of iron defciency anaemia remains a common procedure, but is expensive and time-consuming. Serological investigation for coeli... Read More about Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost‑efective and should be replaced with universally performed pre‑endoscopy serology in patients on a suspected cancer pathway.

Impact of the Macmillan specialist Care at Home service: a mixed methods evaluation across six sites (2018)
Journal Article
Johnston, B., Patterson, A., Bird, L., Wilson, E., Almack, K., Mathews, G., & Seymour, J. (2018). Impact of the Macmillan specialist Care at Home service: a mixed methods evaluation across six sites. BMC Palliative Care, 17(1), https://doi.org/10.1186/s12904-018-0281-9

Background: The Midhurst Macmillan Specialist Palliative Care at Home Service was founded in 2006 to improve community-based palliative care provision. Principal components include; early referral; home-based clinical interventions; close partnershi... Read More about Impact of the Macmillan specialist Care at Home service: a mixed methods evaluation across six sites.

A systematic review and meta-synthesis of the qualitative research into mandatory personal psychotherapy during training (2018)
Journal Article
Murphy, D., Irfan, N., Barnett, H., Castledine, E., & Enescu, L. (in press). A systematic review and meta-synthesis of the qualitative research into mandatory personal psychotherapy during training. Counselling and Psychotherapy Research, 18(2), https://doi.org/10.1002/capr.12162

Background: This study addresses the thorny issue of mandatory personal psychotherapy within counselling and psychotherapy training. It is expensive, emotionally demanding and time-consuming. Nevertheless, proponents argue that it is essential in pro... Read More about A systematic review and meta-synthesis of the qualitative research into mandatory personal psychotherapy during training.

Multiparameter estimation in networked quantum sensors (2018)
Journal Article
Proctor, T. J., Knott, P. A., & Dunningham, J. A. (2018). Multiparameter estimation in networked quantum sensors. Physical Review Letters, 120(8), https://doi.org/10.1103/PhysRevLett.120.080501

We introduce a general model for a network of quantum sensors, and we use this model to consider the following question: When can entanglement between the sensors, and/or global measurements, enhance the precision with which the network can measure a... Read More about Multiparameter estimation in networked quantum sensors.

Health service factors that affect adherence to tuberculosis treatment in Ghana (2018)
Journal Article
Salifu, Y., Eliason, C., & Mensah, G. (2018). Health service factors that affect adherence to tuberculosis treatment in Ghana. Primary Health Care, 28(2), 27-33. https://doi.org/10.7748/phc.2018.e1312

Most of the global cases of tuberculosis (TB) are found in Asia and Africa. This is largely due to deficient educational information, myths, beliefs and suboptimal service delivery as a result of inadequate infrastructure. Even though proper treatmen... Read More about Health service factors that affect adherence to tuberculosis treatment in Ghana.

Switching the uniaxial magnetic anisotropy by ion irradiation induced compensation (2018)
Journal Article
Yuan, Y., Amarouche, T., Xu, C., Rushforth, A., Böttger, R., Edmonds, K., …Zhou, S. (2018). Switching the uniaxial magnetic anisotropy by ion irradiation induced compensation. Journal of Physics D: Applied Physics, 51(14), https://doi.org/10.1088/1361-6463/aab1db

© 2018 IOP Publishing Ltd. In the present work, the uniaxial magnetic anisotropy of GaMnAsP is modified by helium ion irradiation. According to the micro-magnetic parameters, e.g. resonance fields and anisotropy constants deduced from ferromagnetic r... Read More about Switching the uniaxial magnetic anisotropy by ion irradiation induced compensation.

Improved NOE fitting for flexible molecules based on molecular mechanics data – a case study with S-adenosylmethionine (2018)
Journal Article
Bame, J., Hoeck, C., Carrington, M. J., Butts, C. P., Jäger, C. M., & Croft, A. K. (2018). Improved NOE fitting for flexible molecules based on molecular mechanics data – a case study with S-adenosylmethionine. Physical Chemistry Chemical Physics, 11(20), https://doi.org/10.1039/C7CP07265A

The use of molecular dynamics (MD) calculations to derive relative populations of conformers is highly sensitive to both timescale and parameterisation of the MD. Where these calculations are coupled with NOE data to determine the dynamics of a molec... Read More about Improved NOE fitting for flexible molecules based on molecular mechanics data – a case study with S-adenosylmethionine.

Facilitating ecosystem assembly: plant-soil interactions as a restoration tool (2018)
Journal Article
van der Bij, A., Weijters, M., Robbink, R., Harris, J., Pawlett, M., Ritz, K., …van Diggelen, R. (2018). Facilitating ecosystem assembly: plant-soil interactions as a restoration tool. Biological Conservation, 220, https://doi.org/10.1016/j.biocon.2018.02.010

Although plant-soil interactions are increasingly recognized as an important factor in ecosystem restoration, their effects on community assembly during de novo ecosystem establishment are largely unknown. In a heathland restoration trial after topso... Read More about Facilitating ecosystem assembly: plant-soil interactions as a restoration tool.

A novel spatiotemporal home heating controller design: system emulation and field testing (2018)
Journal Article
Kruusimagi, M., Sharples, S., & Robinson, D. (2018). A novel spatiotemporal home heating controller design: system emulation and field testing. Building and Environment, 135, https://doi.org/10.1016/j.buildenv.2018.02.027

We have developed a spatiotemporal heating control algorithm for use in homes. This system utilises a combination of relatively low-tech hardware interfaced with electric heating systems and a smartphone interface to this hardware, and a central serv... Read More about A novel spatiotemporal home heating controller design: system emulation and field testing.

Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink (2018)
Journal Article
Abhishek, A., Nakafero, G., Kuo, C., Mallen, C., Zhang, W., Grainge, M. J., & Doherty, M. (2018). Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink. Rheumatology, 57(6), 977–981. https://doi.org/10.1093/rheumatology/key013

Objectives: To examine temporal trends in all-cause and cause-specific mortality in RA. Methods: Data from the Clinical Practice Research Datalink (CPRD) were used. Incident RA cases and four age, sex and general practice matched controls were id... Read More about Rheumatoid arthritis and excess mortality: down but not out: a primary care cohort study using data from Clinical Practice Research Datalink.

Micro mechanics of the critical state line at high stresses (2018)
Journal Article
de Bono, J. P., & McDowell, G. R. (2018). Micro mechanics of the critical state line at high stresses. Computers and Geotechnics, 98, https://doi.org/10.1016/j.compgeo.2018.02.016

A critical state line is presented for a crushable numerical soil, which is parallel to the isotropic normal compression line. A previous theory for the normal compression line, which correctly predicts the slope as a function of the size-effect on p... Read More about Micro mechanics of the critical state line at high stresses.

Consistent description of field theories with non-Hermitian mass terms (2018)
Journal Article
Alexandre, J., Millington, P., & Seynaeve, D. (2018). Consistent description of field theories with non-Hermitian mass terms. Journal of Physics: Conference Series, 952, https://doi.org/10.1088/1742-6596/952/1/012012

We review how to describe a field theory that includes a non-Hermitian mass term in the region of parameter space where the Lagrangian is PT-symmetric. The discrete symmetries of the system are essential for understanding the consistency of the model... Read More about Consistent description of field theories with non-Hermitian mass terms.

Does the diurnal pattern of enteric methane emissions from dairy cows change over time? (2018)
Journal Article
Bell, M., Craigon, J., Saunders, N., Goodman, J., & Garnsworthy, P. (2018). Does the diurnal pattern of enteric methane emissions from dairy cows change over time?. Animal, 12(10), 2065-2070. https://doi.org/10.1017/S1751731118000228

Diet manipulation and genetic selection are two important mitigation strategies for reducing enteric methane (CH4) emissions from ruminant livestock. The aim of this study was to assess whether the diurnal pattern of CH4 emissions from individual dai... Read More about Does the diurnal pattern of enteric methane emissions from dairy cows change over time?.

Use of radiography in small animal practice in the UK and Republic of Ireland in 2013 (2018)
Journal Article
Booth, N. J., Morley, S. J., & Ewers, R. (in press). Use of radiography in small animal practice in the UK and Republic of Ireland in 2013. Veterinary Record, 182(8), https://doi.org/10.1136/vr.104670

Background: Radiography is an essential diagnostic tool in small animal practice. A major transition is currently underway from film-screen to digital systems. However, there is limited published research detailing the use of radiography in practices... Read More about Use of radiography in small animal practice in the UK and Republic of Ireland in 2013.

Spatiotemporal patterns and environmental drivers of human echinococcoses over a twenty-year period in Ningxia Hui Autonomous Region, China (2018)
Journal Article
Cadavid Restrepo, A. M., Yang, Y. R., McManus, D. P., Gray, D. J., Barnes, T. S., Williams, G. M., …Clements, A. C. (2018). Spatiotemporal patterns and environmental drivers of human echinococcoses over a twenty-year period in Ningxia Hui Autonomous Region, China. Parasites and Vectors, 11, Article 108. https://doi.org/10.1186/s13071-018-2693-z

Background Human cystic (CE) and alveolar (AE) echinococcoses are zoonotic parasitic diseases that can be influenced by environmental variability and change through effects on the parasites, animal intermediate and definitive hosts, and human popu... Read More about Spatiotemporal patterns and environmental drivers of human echinococcoses over a twenty-year period in Ningxia Hui Autonomous Region, China.

Micro-pharmacokinetics: quantifying local drug concentration at live cell membranes (2018)
Journal Article
Gherbi, K., Briddon, S. J., & Charlton, S. J. (in press). Micro-pharmacokinetics: quantifying local drug concentration at live cell membranes. Scientific Reports, 8, Article 3479. https://doi.org/10.1038/s41598-018-21100-x

Fundamental equations for determining pharmacological parameters, such as the binding afnity of a ligand for its target receptor, assume a homogeneous distribution of ligand, with concentrations in the immediate vicinity of the receptor being the sam... Read More about Micro-pharmacokinetics: quantifying local drug concentration at live cell membranes.