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A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial (2015)
Journal Article
Harrison, E. F., Haines, R. H., Cowdell, F., Sach, T. H., Dean, T., Pollock, I., …Thomas, K. S. (2015). A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial. Trials, 16(1), https://doi.org/10.1186/s13063-015-0921-9

Background Eczema is a chronic, itchy skin condition that can have a large impact on the quality of life of patients and their families. People with eczema are often keen to try out non-pharmacological therapies like silk therapeutic garments that... Read More about A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial.

Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial (2015)
Journal Article
Ormerod, A. D., Thomas, K. S., Craig, F. E., Mitchell, E., Greenlaw, N., Norrie, J., …UK Dermatology Clinical Trials Network’s STOP GAP team. (2015). Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial. BMJ, 350, Article h2958. https://doi.org/10.1136/bmj.h2958

Objective: To determine whether ciclosporin is superior to prednisolone for the treatment of pyoderma gangrenosum, a painful, ulcerating skin disease with a poor evidence base for management. Design: Multicentre, parallel group, observer blind, ran... Read More about Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial.

Validation of treatment escalation as a definition of atopic eczema flares (2015)
Journal Article
Thomas, K. S., Stuart, B., O’Leary, C., Schmitt, J., Paul, C., Williams, H., & Langan, S. (2015). Validation of treatment escalation as a definition of atopic eczema flares. PLoS ONE, 10(4), 1-13. https://doi.org/10.1371/journal.pone.0124770

Background Atopic eczema (AE) is a chronic disease with flares and remissions. Long-term control of AE flares has been identified as a core outcome domain for AE trials. However, it is unclear how flares should be defined and measured. Objective... Read More about Validation of treatment escalation as a definition of atopic eczema flares.

The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology (2015)
Journal Article
Schmitt, J., Apfelbacher, C., Spuls, P. I., Thomas, K. S., Simpson, E. L., Furue, M., …Williams, H. C. (2015). The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology. Journal of Investigative Dermatology, 135(1), 24-30. https://doi.org/10.1038/jid.2014.320

Core outcome sets (COSs) are consensus-derived minimum sets of outcomes to be assessed in a specific situation. COSs are being increasingly developed to limit outcome-reporting bias, allow comparisons across trials, and strengthen clinical decision m... Read More about The Harmonizing Outcome Measures for Eczema (HOME) roadmap: a methodological framework to develop core sets of outcome measurements in dermatology.

What is a pragmatic clinical trial? (2015)
Journal Article
Williams, H. C., BURDEN-TEH, E., & Nunn, A. J. (2015). What is a pragmatic clinical trial?. Journal of Investigative Dermatology, 135(6), 1-3. doi:10.1038/jid.2015.134

Can a simple outpatient-based treatment be used to treat cutaneous leishmaniasis in young children? A critically appraised topic (2014)
Journal Article
Burden-Teh, E., Wooton, C., & Williams, H. (2015). Can a simple outpatient-based treatment be used to treat cutaneous leishmaniasis in young children? A critically appraised topic. British Journal of Dermatology, 172(4), 861-866. doi:10.1111/bjd.13496

A 5‐year‐old boy from rural Afghanistan presented with a 1‐year history of a skin lesion on his left knee, confirmed by polymerase chain reaction to be cutaneous leishmaniasis (Leishmania tropica). Conventional treatment of cutaneous leishmaniasis in... Read More about Can a simple outpatient-based treatment be used to treat cutaneous leishmaniasis in young children? A critically appraised topic.

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention (2014)
Journal Article
Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., Irwin McLean, W., …Williams, H. C. (2014). Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. Journal of Allergy and Clinical Immunology, 134(4), 818-823. https://doi.org/10.1016/j.jaci.2014.08.005

Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and is increasing in prevalence. Because of the significant socioeconomic effect of atopic dermatitis and its effect... Read More about Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention.

The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials (2014)
Journal Article
Schmitt, J., Spuls, P. I., Thomas, K. S., Simpson, E., Furue, M., Deckert, S., …Williams, H. C. (2014). The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials. Journal of Allergy and Clinical Immunology, 134(4), 800-807. https://doi.org/10.1016/j.jaci.2014.07.043

The lack of core outcome sets for atopic eczema (AE) is a major obstacle for advancing evidence-based treatment. The global Harmonising Outcome Measures for Eczema (HOME) initiative has already defined clinical signs, symptoms, quality of life, and l... Read More about The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials.

Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 (2014)
Journal Article
Wang, H., Liddell, C. A., Coates, M. M., Mooney, M. D., Levitz, C. E., Schumacher, A. E., …Murray, C. J. L. (2014). Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384(9947), 957-979. https://doi.org/10.1016/s0140-6736%2814%2960497-9

Background Remarkable financial and political efforts have been focused on the reduction of child mortality during the past few decades. Timely measurements of levels and trends in under-5 mortality are important to assess progress towards the Mi... Read More about Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.

Rehabilitation aimed at improving outdoor mobility for people after stroke: a multi-centre randomised controlled study (the Getting out of the House Study) (2014)
Journal Article
Logan, P. A., Armstrong, S., Avery, T., Barer, D., Barton, G., Darby, J., …Leighton, M. P. (2014). Rehabilitation aimed at improving outdoor mobility for people after stroke: a multi-centre randomised controlled study (the Getting out of the House Study). Health Technology Assessment, 18(29), 1-73. https://doi.org/10.3310/hta18290

Background: One-third of stroke patients are dependent on others to get outside their homes. This can cause people to become housebound, leading to increased immobility, poor health, isolation and misery. There is some evidence that outdoor mobility... Read More about Rehabilitation aimed at improving outdoor mobility for people after stroke: a multi-centre randomised controlled study (the Getting out of the House Study).

Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection (2014)
Journal Article
Elliker, K. R., Armstrong, S., Sommerville, B. A., Broom, D. M., Neal, D. E., & Williams, H. C. (2014). Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection. BMC Urology, 14(1), 1-9. https://doi.org/10.1186/1471-2490-14-22

Background: Cancer detection using sniffer dogs is a potential technology for clinical use and research. Our study sought to determine whether dogs could be trained to discriminate the odour of urine from men with prostate cancer from controls, using... Read More about Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection.

Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials. (2014)
Journal Article
Mason, J. M., Thomas, K., Crook, A. M., Foster, K. A., Chalmers, J., Nunn, A. J., & Williams, H. C. (2014). Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials. PLoS ONE, 9(2), https://doi.org/10.1371/journal.pone.0082694

Background Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. We assessed the cost-effectiveness of prophylactic antibiotic treatment to prevent the recurrence of cellulitis using low dose... Read More about Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials..

Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial (2013)
Journal Article
Bath-Hextall, F., Ozolins, M., Armstrong, S. J., Colver, G. B., Perkins, W., Miller, P. S., & Williams, H. C. (2014). Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial. Lancet Oncology, 15(1), 96-105. https://doi.org/10.1016/S1470-2045%2813%2970530-8

Background: Basal-cell carcinoma is the most common form of skin cancer and its incidence is increasing worldwide. We aimed to assess the effectiveness of imiquimod cream versus surgical excision in patients with low-risk basal-cell carcinoma. Method... Read More about Surgical excision versus imiquimod 5% cream for nodular and superficial basal-cell carcinoma (SINS): a multicentre, non-inferiority, randomised controlled trial.

The Cochrane Skin Group: a vanguard for developing and promoting evidence-based dermatology (2013)
Journal Article
Reddi, A., Prescott, L., Doney, E., Delamere, F., Kollipara, R., Dellavalle, R. P., & Williams, H. C. (2013). The Cochrane Skin Group: a vanguard for developing and promoting evidence-based dermatology. Journal of Evidence-Based Medicine, 6(4), https://doi.org/10.1111/jebm.12068

Aim The Cochrane Skin Group (CSG) is part of the international Cochrane Collaboration (http://www.cochrane.org/). The CSG prepares, maintains and disseminates high quality evidence-based summaries on the prevention, diagnosis and treatment of skin d... Read More about The Cochrane Skin Group: a vanguard for developing and promoting evidence-based dermatology.

What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod?: a discrete choice experiment survey from the SINS trial (2012)
Journal Article
Tinelli, M., Ozolins, M., Bath-Hextall, F., & Williams, H. C. (2012). What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod?: a discrete choice experiment survey from the SINS trial. BMC Dermatology, 12(Octobe), Article 11. https://doi.org/10.1186/1471-5945-12-19

Background: The SINS trial (Controlled Clinical Trials ISRCTN48755084; Eudract No. 2004-004506-24) is a randomised controlled trial evaluating long term success of excisional surgery vs. imiquimod 5% cream for low risk nodular and superficial basal... Read More about What determines patient preferences for treating low risk basal cell carcinoma when comparing surgery vs imiquimod?: a discrete choice experiment survey from the SINS trial.

UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial (2012)
Journal Article
Craig, F. F., Thomas, K. S., Mitchell, E. J., Williams, H. C., Norrie, J., Mason, J. M., & Ormerod, A. D. (2012). UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial. Trials, 13(1), Article 51. https://doi.org/10.1186/1745-6215-13-51

Established corticosteroid creams should be applied only once daily in patients with atopic eczema (2007)
Journal Article
Williams, H. C. (2007). Established corticosteroid creams should be applied only once daily in patients with atopic eczema. British medical journal, 334,

Atopic eczema affects many adults and up to 20% of children,1 with health costs comparable to diabetes2 and asthma.3 One community survey of 1760 young children in the United Kingdom found that 84% had mild eczema, 14% moderate, and 2% severe eczema.... Read More about Established corticosteroid creams should be applied only once daily in patients with atopic eczema.

Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg (2007)
Journal Article
Thomas, K. S., Cox, N. H., Savelyich, B. S., Shipley, D., Meredith, S., Nunn, A., …Reynolds, N. (2007). Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg. Trials, 8(3),

Background: This paper describes the results of a feasibility study for a randomised controlled trial (RCT). Methods: Twenty-nine members of the UK Dermatology Clinical Trials Network (UK DCTN) expressed an interest in recruiting for this study.... Read More about Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg.