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Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers (2022)
Journal Article
Alblihy, A., Ali, R., Algethami, M., Shoqafi, A., Toss, M. S., Brownlie, J., …Madhusudan, S. (2022). Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. npj Precision Oncology, 6(1), https://doi.org/10.1038/s41698-022-00298-0

Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Here we have... Read More about Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers.

Investigation of humans individual differences as predictors of their animal interaction styles, focused on the domestic cat (2022)
Journal Article
Finka, L. R., Ripari, L., Quinlan, L., Haywood, C., Puzzo, J., Jordan, A., …Brennan, M. L. (2022). Investigation of humans individual differences as predictors of their animal interaction styles, focused on the domestic cat. Scientific Reports, 12(1), Article 12128. https://doi.org/10.1038/s41598-022-15194-7

Humans' individual differences including their demographics, personality, attitudes and experiences are often associated with important outcomes for the animals they interact with. This is pertinent to companion animals such as cats and dogs, given t... Read More about Investigation of humans individual differences as predictors of their animal interaction styles, focused on the domestic cat.

Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour (2022)
Journal Article
Hill, E. M., Prosser, N. S., Ferguson, E., Kaler, J., Green, M. J., Keeling, M. J., & Tildesley, M. J. (2022). Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour. PLoS Computational Biology, 18(7), Article e1010235. https://doi.org/10.1371/journal.pcbi.1010235

The spread of infection amongst livestock depends not only on the traits of the pathogen and the livestock themselves, but also on the veterinary health behaviours of farmers and how this impacts their implementation of disease control measures. Cont... Read More about Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour.

Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour. (2022)
Journal Article
Hill, E. M., Prosser, N. S., Ferguson, E., Kaler, J., Green, M. J., Keeling, M. J., & Tildesley, M. J. (2022). Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour. PLoS Computational Biology, 18(7), Article e1010235. https://doi.org/10.1371/journal.pcbi.1010235

Background: The spread of infection amongst livestock depends not only on the traits of the pathogen and the livestock themselves, but also on the behavioural characteristics of farmers and how that impacts the implementation of livestock disease con... Read More about Modelling livestock infectious disease control policy under differing social perspectives on vaccination behaviour..

Levels of Evidence, Quality Assessment, and Risk of Bias: Evaluating the Internal Validity of Primary Research (2022)
Journal Article
Sargeant, J. M., Brennan, M. L., & O'Connor, A. M. (2022). Levels of Evidence, Quality Assessment, and Risk of Bias: Evaluating the Internal Validity of Primary Research. Frontiers in Veterinary Science, 9, Article 960957. https://doi.org/10.3389/fvets.2022.960957

Clinical decisions in human and veterinary medicine should be based on the best available evidence. The results of primary research are an important component of that evidence base. Regardless of whether assessing studies for clinical case management... Read More about Levels of Evidence, Quality Assessment, and Risk of Bias: Evaluating the Internal Validity of Primary Research.

Stability selection for mixed effect models with large numbers of predictor variables: A simulation study (2022)
Journal Article
Hyde, R., O'Grady, L., & Green, M. (2022). Stability selection for mixed effect models with large numbers of predictor variables: A simulation study. Preventive Veterinary Medicine, 206, Article 105714. https://doi.org/10.1016/j.prevetmed.2022.105714

Covariate selection when the number of available variables is large relative to the number of observations is problematic in epidemiology and remains the focus of continued research. Whilst a variety of statistical methods have been developed to atte... Read More about Stability selection for mixed effect models with large numbers of predictor variables: A simulation study.

A Prospective Cohort Study Investigating the Behavioural Development of Bitches in a Guide Dog Training Programme Neutered Prepubertally or Post-Pubertally (2022)
Journal Article
Moxon, R., Freeman, S., Payne, R., Corr, S., & England, G. C. W. (2022). A Prospective Cohort Study Investigating the Behavioural Development of Bitches in a Guide Dog Training Programme Neutered Prepubertally or Post-Pubertally. Frontiers in Veterinary Science, 9, Article 902775. https://doi.org/10.3389/fvets.2022.902775

There are few studies that investigate the effect of neutering bitches before or after puberty. The majority of current literature examining the impact of the timing of neutering on health and behaviour has used age rather than the onset of puberty a... Read More about A Prospective Cohort Study Investigating the Behavioural Development of Bitches in a Guide Dog Training Programme Neutered Prepubertally or Post-Pubertally.

The impact of glutaraldehyde based footbaths on Dichelobacter nodosus prevalence and the antimicrobial resistant community of the ovine interdigital skin (2022)
Journal Article
Marshall, H. J., Blanchard, A. M., Kelly, K. R., Goh, J. N., Williams, A. D., King, L., …Tötemeyer, S. (2022). The impact of glutaraldehyde based footbaths on Dichelobacter nodosus prevalence and the antimicrobial resistant community of the ovine interdigital skin. Veterinary Microbiology, 272, Article 109459. https://doi.org/10.1016/j.vetmic.2022.109459

Ovine footrot, is a highly contagious polymicrobial bacterial infection, primarily caused by Dichelobacter nodosus. Preventative bactericidal footbaths are commonly used in the sheep industry to reduce the spread of bacteria. However, their effect on... Read More about The impact of glutaraldehyde based footbaths on Dichelobacter nodosus prevalence and the antimicrobial resistant community of the ovine interdigital skin.

Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach (2022)
Journal Article
Bouten, M., & Elsheikha, H. M. (2022). Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach. Parasitologia, 2(3), 167-197. https://doi.org/10.3390/parasitologia2030016

Acanthamoeba keratitis (AK) is a potentially blinding infection caused by protozoa found worldwide. The topical application of biguanides and diamidines is the most common anti-amoebic treatment for AK. In this study, we hypothesized that geographica... Read More about Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach.

Welfare indicators for stunning versus non‐stunning slaughter in sheep and cattle: A scoping review (2022)
Journal Article
Tetlow, S. A. J., Brennan, M. L., & Garcia‐Ara, A. (2022). Welfare indicators for stunning versus non‐stunning slaughter in sheep and cattle: A scoping review. Veterinary Record, 191(6), Article e1739. https://doi.org/10.1002/vetr.1739

Background: While most cattle and sheep in the United Kingdom are stunned before slaughter, non-stun methods are permitted to supply meat to specific consumers. This study aimed to identify the existing literature that compared animal welfare indicat... Read More about Welfare indicators for stunning versus non‐stunning slaughter in sheep and cattle: A scoping review.

Working with farmers to optimise mineral balance in grazing sheep (2022)
Journal Article
Clarkson, A., Angell, J., & Kendall, N. (2022). Working with farmers to optimise mineral balance in grazing sheep. In Practice, 44(6), 348-356. https://doi.org/10.1002/inpr.229

Background: Trace mineral analysis is a useful but underused tool in ruminant livestock production. Routine on-farm use of diagnostic techniques can help to ensure animal nutritional requirements are being met through improved supplementation choices... Read More about Working with farmers to optimise mineral balance in grazing sheep.

Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals (2022)
Journal Article
Wang, C., Qu, R., Zong, Y., Qin, C., Liu, L., Gao, X., …Pu, J. (2022). Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals. PLoS Pathogens, 18(7), Article e1010645. https://doi.org/10.1371/journal.ppat.1010645

Avian influenza virus (AIV) can evolve multiple strategies to combat host antiviral defenses and establish efficient infectivity in mammals, including humans. H9N2 AIV and its reassortants (such as H5N6 and H7N9 viruses) pose an increasing threat to... Read More about Enhanced stability of M1 protein mediated by a phospho-resistant mutation promotes the replication of prevailing avian influenza virus in mammals.

Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution (2022)
Journal Article
Tarlinton, R. E., Legione, A. R., Sarker, N., Fabijan, J., Meers, J., McMichael, L., …Emes, R. D. (2022). Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution. Journal of General Virology, 103(6), Article 001749. https://doi.org/10.1099/jgv.0.001749

Koala retrovirus (KoRV) is unique amongst endogenous (inherited) retroviruses in that its incorporation to the host genome is still active, providing an opportunity to study what drives this fundamental process in vertebrate genome evolution. Animals... Read More about Differential and defective transcription of koala retrovirus indicates the complexity of host and virus evolution.

An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation (2022)
Journal Article
Badenhorst, M., Saalmüller, A., Daly, J. M., Ertl, R., Stadler, M., Puff, C., …Cavalleri, J. V. (2022). An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation. Viruses, 14(7), Article 1401. https://doi.org/10.3390/v14071401

Equine hepacivirus (EqHV) is the closest known genetic homologue of hepatitis C virus. An effective prophylactic vaccine is currently not available for either of these hepaciviruses. The equine as potential surrogate model for hepacivirus vaccine stu... Read More about An Equine Model for Vaccination against a Hepacivirus: Insights into Host Responses to E2 Recombinant Protein Vaccination and Subsequent Equine Hepacivirus Inoculation.

Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts (2022)
Journal Article
Sharpe, B. P., Hayden, A., Manousopoulou, A., Cowie, A., Walker, R. C., Harrington, J., …Underwood, T. J. (2022). Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts. Cell Reports Medicine, 3(6), Article 100541. https://doi.org/10.1016/j.xcrm.2022.100541

The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type,... Read More about Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts.

Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018) (2022)
Journal Article
Curwen, A., Jones, S., Stayley, C., Eden, L., McKay, H., Davies, P., …Tarlinton, R. (2022). Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018). Veterinary Record Open, 9(1), Article e39. https://doi.org/10.1002/vro2.39

Background Schmallenberg virus is a midge borne arbovirus that first emerged in the European ruminant population in 2011 and has since settled to an endemic pattern of disease The impacts of trade restrictions on genetic products (semen, embryos) f... Read More about Failure to detect Schmallenberg Virus in ram semen in the UK (2016-2018).

Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs (2022)
Journal Article
Elcombe, C. S., Monteiro, A., Elcombe, M. R., Ghasemzadeh-Hasankolaei, M., Sinclair, K. D., Lea, R., …Bellingham, M. (2022). Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs. Environmental Toxicology and Pharmacology, 94, Article 103913. https://doi.org/10.1016/j.etap.2022.103913

Current declines in male reproductive health may, in part, be driven by anthropogenic environmental chemical (EC) exposure. Using a biosolids treated pasture (BTP) sheep model, this study examined the effects of gestational exposure to a translationa... Read More about Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs.

Scoping review of end-of-life decision-making models used in dogs, cats and equids (2022)
Journal Article
Cameron, A., Pollock, K., Wilson, E., Burford, J., England, G., & Freeman, S. (2022). Scoping review of end-of-life decision-making models used in dogs, cats and equids. Veterinary Record, 191(4), Article e1730. https://doi.org/10.1002/vetr.1730

Background: End-of-life decisions for companion animals can be stressful for veterinarians and owners, and when delayed result in poor animal welfare. Delayed euthanasia has been identified as a particularly prominent issue for horses. This scoping r... Read More about Scoping review of end-of-life decision-making models used in dogs, cats and equids.

Analysis of phenotype-genotype associations using genomic informational field theory (GIFT) (2022)
Journal Article
Wattis, J. A., Bray, S. M., Kyratzi, P., & Rauch, C. (2022). Analysis of phenotype-genotype associations using genomic informational field theory (GIFT). Journal of Theoretical Biology, 548, Article 111198. https://doi.org/10.1016/j.jtbi.2022.111198

We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known genotypes, we... Read More about Analysis of phenotype-genotype associations using genomic informational field theory (GIFT).