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A Combined Offline and Online Algorithm for Real-Time and Long-Term Classification of Sheep Behaviour: Novel Approach for Precision Livestock Farming (2019)
Journal Article
Vázquez-Diosdado, J. A., Paul, V., Ellis, K. A., Coates, D., Loomba, R., & Kaler, J. (2019). A Combined Offline and Online Algorithm for Real-Time and Long-Term Classification of Sheep Behaviour: Novel Approach for Precision Livestock Farming. Sensors, 19(14), Article 3201. https://doi.org/10.3390/s19143201

Real-time and long-term behavioural monitoring systems in precision livestock farming have huge potential to improve welfare and productivity for the better health of farm animals. However, some of the biggest challenges for long-term monitoring syst... Read More about A Combined Offline and Online Algorithm for Real-Time and Long-Term Classification of Sheep Behaviour: Novel Approach for Precision Livestock Farming.

Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells (2019)
Journal Article
Gao, W., Zu, Z., Liu, J., Song, J., Wang, X., Wang, C., Liu, L., Tong, Q., Wang, M., Sun, H., Sun, Y., Liu, J., Chang, K. C., & Pu, J. (2019). Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells. Journal of General Virology, 100(9), 1273-1281. https://doi.org/10.1099/jgv.0.001294

Adaptation of PB2 protein is important for the establishment of avian influenza viruses in mammalian hosts. Here, we identify I292V as the prevalent mutation in PB2 of circulating avian H9N2 and pandemic H1N1 viruses. The same dominant PB2 mutation i... Read More about Prevailing I292V PB2 mutation in avian influenza H9N2 virus increases viral polymerase function and attenuates IFN-β induction in human cells.

Linear magnetic resonance imaging measurements of the hippocampal formation differ in young versus old dogs (2019)
Journal Article
Gardini, A., Taeymans, O., Cherubini, G. B., de Stefani, A., Targett, M., & Vettorato, E. (2019). Linear magnetic resonance imaging measurements of the hippocampal formation differ in young versus old dogs. Veterinary Record, 185(10), Article 306. https://doi.org/10.1136/vr.105243

Age-related hippocampal formation (HF) atrophy has been documented on MRI studies using volumetric analysis and visual rating scales.This retrospective cross-sectional study aimed to compare linear MRI measurements of the HF between young (1–3 years)... Read More about Linear magnetic resonance imaging measurements of the hippocampal formation differ in young versus old dogs.

Equine herpesviruses: a roundtable discussion (2019)
Journal Article
Newton, J. R., Ivens, P., Bryant, N., Kydd, J., Rendle, D., Knapp, S., Neal, H., Crabtree, J., & Moore, S. (2019). Equine herpesviruses: a roundtable discussion. UK-Vet Equine, 3(Sup4), 1-12. https://doi.org/10.12968/ukve.2019.3.S2.1

There are nine different equid herpesviruses (EHVs). Five types (EHV-1 to EHV-5) infect the domestic horse, while EHV-6 to EHV-9 are associated with infections in wild equids including asses and zebra. This review focuses on the commonest and most im... Read More about Equine herpesviruses: a roundtable discussion.

Risk factors for acute abdominal pain (colic) in the adult horse: A scoping review of risk factors, and a systematic review of the effect of management-related changes (2019)
Journal Article
Curtis, L., Burford, J. H., England, G. C. W., & Freeman, S. L. (2019). Risk factors for acute abdominal pain (colic) in the adult horse: A scoping review of risk factors, and a systematic review of the effect of management-related changes. PLoS ONE, 14(7), 1-32. https://doi.org/10.1371/journal.pone.0219307

Acute abdominal pain (colic) is the most common reason for emergency veterinary treatment in the horse. Consolidation of data through a systematic review is important to inform evidence-based medicine and clinical guidelines, but there are currently... Read More about Risk factors for acute abdominal pain (colic) in the adult horse: A scoping review of risk factors, and a systematic review of the effect of management-related changes.

Could Greater Time Spent Displaying Waking Inactivity in the Home Environment Be a Marker for a Depression-Like State in the Domestic Dog? (2019)
Journal Article
Harvey, N. D., Moesta, A., Kappel, S., Wongsaengchan, C., Harris, H., Craigon, P. J., & Fureix, C. (2019). Could Greater Time Spent Displaying Waking Inactivity in the Home Environment Be a Marker for a Depression-Like State in the Domestic Dog?. Animals, 9(7), Article 420. https://doi.org/10.3390/ani9070420

Dogs exposed to aversive events can become inactive and unresponsive and are commonly referred to as being "depressed", but this association remains to be tested. We investigated whether shelter dogs spending greater time inactive "awake but motionle... Read More about Could Greater Time Spent Displaying Waking Inactivity in the Home Environment Be a Marker for a Depression-Like State in the Domestic Dog?.

Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii-Induced Transcriptional Landscapes (2019)
Journal Article
He, J.-J., Ma, J., Wang, J.-L., Zhang, F.-K., Li, J.-X., Zhai, B.-T., Wang, Z.-X., Elsheikha, H. M., & Zhu, X.-Q. (2019). Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii-Induced Transcriptional Landscapes. Frontiers in Immunology, 10, Article 1531. https://doi.org/10.3389/fimmu.2019.01531

© 2019 He, Ma, Wang, Zhang, Li, Zhai, Wang, Elsheikha and Zhu. We characterized the porcine tissue transcriptional landscapes that follow Toxoplasma gondii infection. RNAs were isolated from liver, spleen, cerebral cortex, lung, and mesenteric lymph... Read More about Global Transcriptome Profiling of Multiple Porcine Organs Reveals Toxoplasma gondii-Induced Transcriptional Landscapes.

Preparation for equine handling can be taught by video (2019)
Presentation / Conference Contribution
Ferguson, G., Statton, J., Hammond, P., & Kydd, J. (2019, July). Preparation for equine handling can be taught by video. Poster presented at VetEd, Rothamsted, Harpenden, UK

Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications (2019)
Journal Article
Mistry, H. D., Kurlak, L. O., Gardner, D. S., Torffvit, O., Hansen, A., Broughton Pipkin, F., & Strevens, H. (2019). Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications. Journal of the American Heart Association, 8(13), 1-11. https://doi.org/10.1161/JAHA.119.012611

Background-—AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT, as a component of the intrarenal renin–angiotensin system. We investigated urinary AGT, as a biomarker for renin–angiotensin... Read More about Evidence of augmented intrarenal angiotensinogen associated with glomerular swelling in gestational hypertension and pre-eclampsia: clinical implications.

Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia (2019)
Journal Article
Garanina, E., Martynova, E., Davidyuk, Y., Kabwe, E., Ivanov, K., Titova, A., Markelova, M., Zhuravleva, M., Cherepnev, G., Shakirova, V. G., Khaertynova, I., Tarlinton, R., Rizvanov, A., Khaiboullina, S., & Morzunov, S. (2019). Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. Viruses, 11(7), 1-20. https://doi.org/10.3390/v11070601

Hemorrhagic fever with renal syndrome (HFRS) is endemic in Tatarstan, where thousands of cases are registered annually. Puumala orthohantavirus is commonly detected in human case samples as well as in captured bank voles, the rodent hosts. The pathog... Read More about Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia.

Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot (2019)
Journal Article
Jacquot, M., Rao, P. P., Yadav, S., Nomikou, K., Maan, S., Jyothi, Y. K., Reddy, N., Putty, K., Hemadri, D., Singh, K. P., Maan, N. S., Hegde, N. R., Mertens, P., & Biek, R. (2019). Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot. Virus Evolution, 5(2), Article vez027. https://doi.org/10.1093/ve/vez027

For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes,... Read More about Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot.

Molecular variability of Streptococcus uberis isolates from intramammary infections in Canadian dairy farms from the Maritime region (2019)
Journal Article
Reyes, J., Rodriguez-Lecompte, J. C., Blanchard, A., McClure, J., & Sánchez, J. (2019). Molecular variability of Streptococcus uberis isolates from intramammary infections in Canadian dairy farms from the Maritime region. Canadian Journal of Veterinary Research, 83(3), 168-176

The primary objective of this study was to explore the variability of Streptococcus uberis (S. uberis) isolates by extracting multilocus sequence typing (MLST) data from whole-genome sequencing. The secondary objective was to determine the distributi... Read More about Molecular variability of Streptococcus uberis isolates from intramammary infections in Canadian dairy farms from the Maritime region.

Technology adoption on farms: Using Normalisation Process Theory to understand sheep farmers’ attitudes and behaviours in relation to using precision technology in flock management (2019)
Journal Article
Kaler, J., & Ruston, A. (2019). Technology adoption on farms: Using Normalisation Process Theory to understand sheep farmers’ attitudes and behaviours in relation to using precision technology in flock management. Preventive Veterinary Medicine, 170, Article 104715. https://doi.org/10.1016/j.prevetmed.2019.104715

Evidence suggests that UK sheep farmers experience lower productivity and profit margins than other livestock sectors and that they do not necessarily know where they gain or lose income from their flocks. More efficient use of precision technology h... Read More about Technology adoption on farms: Using Normalisation Process Theory to understand sheep farmers’ attitudes and behaviours in relation to using precision technology in flock management.

Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice (2019)
Journal Article
Fay, P. C., Attoui, H., Batten, C., Mohd Jaafar, F., Lomonossoff, G. P., Daly, J. M., & Mertens, P. P. (2019). Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice. Vaccine, 2, Article 100026. https://doi.org/10.1016/j.jvacx.2019.100026

Bluetongue is a severe, economically important disease of ruminants that is widely distributed in tropical and temperate regions around the world. It is associated with major production losses, restrictions of animal movements and trade, as well as c... Read More about Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice.

Footbathing, formalin and foot trimming: The 3Fs associated with granulomas and shelly hoof in sheep (2019)
Journal Article
Reeves, M., Prosser, N., Monaghan, E., & Green, L. (2019). Footbathing, formalin and foot trimming: The 3Fs associated with granulomas and shelly hoof in sheep. Veterinary Journal, 250, 28-35. https://doi.org/10.1016/j.tvjl.2019.06.002

Granulomas and shelly hoof (SH), are lesions of sheep feet. Our objective was to use data from four questionnaires on lameness sent to English sheep farmers in 2004, 2013, 2014 and 2015 to further understanding of the risks and aetiologies of both le... Read More about Footbathing, formalin and foot trimming: The 3Fs associated with granulomas and shelly hoof in sheep.

Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription (2019)
Journal Article
Utt, A., Rausalu, K., Jakobson, M., Männik, A., Alphey, L., Fragkoudis, R., & Merits, A. (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93(18), Article e00794-19. https://doi.org/10.1128/jvi.00794-19

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. It has a positive sense RNA genome that also serves as the mRNA for four non-structural proteins (nsPs) representing subunits of the viral replicase. Coupling of nsP and RNA synthesis complica... Read More about Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription.

Micronutrient and amino acid losses during renal replacement therapy for acute kidney injury (2019)
Journal Article
Oh, W. C., Mafrici, B., Rigby, M., Harvey, D., Sharman, A., Allen, J. C., Mahajan, R., Gardner, D. S., & Devonald, M. A. (2019). Micronutrient and amino acid losses during renal replacement therapy for acute kidney injury. Kidney International Reports, 4(8), 1094-1108. https://doi.org/10.1016/j.ekir.2019.05.001

© 2019 International Society of Nephrology Introduction: Malnutrition is common in patients with acute kidney injury (AKI), particularly in those requiring renal replacement therapy (RRT). Use of RRT removes metabolic waste products and toxins, but i... Read More about Micronutrient and amino acid losses during renal replacement therapy for acute kidney injury.

The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function (2019)
Journal Article
Awuah, D., Alobaid, M., Latif, A., Salazar, F., Emes, R. D., & Ghaemmaghami, A. M. (2019). The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function. Journal of Immunology, 203(1), 148-157. https://doi.org/10.4049/jimmunol.1801108

MicroRNAs are small, noncoding RNAs that function as posttranscriptional modulators of gene expression by binding target mRNAs and inhibiting translation. They are therefore crucial regulators of several biological as well as immunological events. Re... Read More about The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function.