Ekaterina Garanina
Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia
Garanina, Ekaterina; Martynova, Ekaterina; Davidyuk, Yuriy; Kabwe, Emmanuel; Ivanov, Konstantin; Titova, Angelina; Markelova, Maria; Zhuravleva, Margarita; Cherepnev, Georgiy; Shakirova, Venera G.; Khaertynova, Ilseyar; Tarlinton, Rachael; Rizvanov, Albert; Khaiboullina, Svetlana; Morzunov, Sergey
Authors
Ekaterina Martynova
Yuriy Davidyuk
Emmanuel Kabwe
Konstantin Ivanov
Angelina Titova
Maria Markelova
Margarita Zhuravleva
Georgiy Cherepnev
Venera G. Shakirova
Ilseyar Khaertynova
Professor RACHAEL TARLINTON rachael.tarlinton@nottingham.ac.uk
Associate Professor
Albert Rizvanov
Svetlana Khaiboullina
Sergey Morzunov
Abstract
Hemorrhagic fever with renal syndrome (HFRS) is endemic in Tatarstan, where thousands of cases are registered annually. Puumala orthohantavirus is commonly detected in human case samples as well as in captured bank voles, the rodent hosts. The pathogenesis of HFRS is still not well described, although the cytokine storm hypothesis is largely accepted. In this study, we present a comprehensive analysis of a fatal HFRS case compared with twenty four non-fatal cases where activation of the humoral and cellular immune responses, pro-inflammatory cytokines and disturbed blood coagulation were detected using immunological, histological, genetic and clinical approaches. Multiple organ failure combined with disseminated intravascular coagulation syndrome and acute renal failure was the cause of death. Decreased Interleukin (IL)-7 and increased IL-18, chemokine (C-C motif) ligand (CCL)-5, stem cell growth factor (SCGF)-b and tumor necrosis factor-beta (TNF-β) serum levels were found, supporting the cytokine storm hypothesis of hantavirus pathogenesis.
Citation
Garanina, E., Martynova, E., Davidyuk, Y., Kabwe, E., Ivanov, K., Titova, A., …Morzunov, S. (2019). Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. Viruses, 11(7), 1-20. https://doi.org/10.3390/v11070601
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 29, 2019 |
Online Publication Date | Jul 2, 2019 |
Publication Date | Jul 2, 2019 |
Deposit Date | Jul 3, 2019 |
Publicly Available Date | Mar 29, 2024 |
Journal | Viruses |
Electronic ISSN | 1999-4915 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 7 |
Article Number | 601 |
Pages | 1-20 |
DOI | https://doi.org/10.3390/v11070601 |
Keywords | HFRS; IL-18; CCL5; SCGF-b; TNF-β; cytokine; fatal case; Puumala orthohantavirus |
Public URL | https://nottingham-repository.worktribe.com/output/2264169 |
Publisher URL | https://www.mdpi.com/1999-4915/11/7/601 |
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Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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