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Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia

Garanina, Ekaterina; Martynova, Ekaterina; Davidyuk, Yuriy; Kabwe, Emmanuel; Ivanov, Konstantin; Titova, Angelina; Markelova, Maria; Zhuravleva, Margarita; Cherepnev, Georgiy; Shakirova, Venera G.; Khaertynova, Ilseyar; Tarlinton, Rachael; Rizvanov, Albert; Khaiboullina, Svetlana; Morzunov, Sergey

Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia Thumbnail


Authors

Ekaterina Garanina

Ekaterina Martynova

Yuriy Davidyuk

Emmanuel Kabwe

Konstantin Ivanov

Angelina Titova

Maria Markelova

Margarita Zhuravleva

Georgiy Cherepnev

Venera G. Shakirova

Ilseyar Khaertynova

Albert Rizvanov

Svetlana Khaiboullina

Sergey Morzunov



Abstract

Hemorrhagic fever with renal syndrome (HFRS) is endemic in Tatarstan, where thousands of cases are registered annually. Puumala orthohantavirus is commonly detected in human case samples as well as in captured bank voles, the rodent hosts. The pathogenesis of HFRS is still not well described, although the cytokine storm hypothesis is largely accepted. In this study, we present a comprehensive analysis of a fatal HFRS case compared with twenty four non-fatal cases where activation of the humoral and cellular immune responses, pro-inflammatory cytokines and disturbed blood coagulation were detected using immunological, histological, genetic and clinical approaches. Multiple organ failure combined with disseminated intravascular coagulation syndrome and acute renal failure was the cause of death. Decreased Interleukin (IL)-7 and increased IL-18, chemokine (C-C motif) ligand (CCL)-5, stem cell growth factor (SCGF)-b and tumor necrosis factor-beta (TNF-β) serum levels were found, supporting the cytokine storm hypothesis of hantavirus pathogenesis.

Citation

Garanina, E., Martynova, E., Davidyuk, Y., Kabwe, E., Ivanov, K., Titova, A., …Morzunov, S. (2019). Cytokine Storm Combined with Humoral Immune Response Defect in Fatal Hemorrhagic Fever with Renal Syndrome Case, Tatarstan, Russia. Viruses, 11(7), 1-20. https://doi.org/10.3390/v11070601

Journal Article Type Article
Acceptance Date Jun 29, 2019
Online Publication Date Jul 2, 2019
Publication Date Jul 2, 2019
Deposit Date Jul 3, 2019
Publicly Available Date Mar 29, 2024
Journal Viruses
Electronic ISSN 1999-4915
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 11
Issue 7
Article Number 601
Pages 1-20
DOI https://doi.org/10.3390/v11070601
Keywords HFRS; IL-18; CCL5; SCGF-b; TNF-β; cytokine; fatal case; Puumala orthohantavirus
Public URL https://nottingham-repository.worktribe.com/output/2264169
Publisher URL https://www.mdpi.com/1999-4915/11/7/601

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