Linear magnetic resonance imaging measurements of the hippocampal formation differ in young versus old dogs

Gardini, Anna; Taeymans, Olivier; Cherubini, Giunio Bruto; de Stefani, Alberta; Targett, Mike; Vettorato, Enzo

Abstract

Age-related hippocampal formation (HF) atrophy has been documented on MRI studies using volumetric analysis and visual rating scales.This retrospective cross-sectional study aimed to compare linear MRI measurements of the HF between young (1–3 years) and old (>10 years) non-brachycephalic dogs, with normal brain anatomy and cerebrospinal fluid (CSF) analysis. Right and left hippocampal formation height (HFH), height of the brain (HB) and mean HFH/HB ratio were measured by two observers on a transverse T2 fluid-attenuated inversion recovery sequence containing rostral colliculi and mesencephalic aqueduct.119 MRI studies were enrolled: 75 young and 44 old dogs. Left and right HFH were greater (p

Citation

Gardini, A., Taeymans, O., Cherubini, G. B., de Stefani, A., Targett, M., & Vettorato, E. (2019). Linear magnetic resonance imaging measurements of the hippocampal formation differ in young versus old dogs. Veterinary Record, 185(10), https://doi.org/10.1136/vr.105243

• Journal Article Type: Article
• Acceptance Date: Jun 23, 2019
• Online Publication Date: Jul 15, 2019
• Publication Date: Sep 30, 2019
• Deposit Date: Aug 2, 2019
• Publicly Available Date: Aug 2, 2019
• Journal: Veterinary Record
• Print ISSN: 0042-4900
• Electronic ISSN: 2042-7670
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 185
• Issue: 10
• Article Number: 306
• DOI: https://doi.org/10.1136/vr.105243
• Public URL: https://nottingham-repository.worktribe.com/output/2379511
• Publisher URL: https://veterinaryrecord.bmj.com/content/early/2019/07/14/vr.105243