All Outputs (29)

The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing (2018)
Journal Article
Labisso, W., Raulin, A., Nwidu, L., Kocon, A., Wayne, D., Erdozain, A., …Carter, W. (2018). The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing. Brain Sciences, 8(9), Article 175. https://doi.org/10.3390/brainsci8090175

Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human post-mortem tissue from Brodmann’s area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals w... Read More about The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing.

Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment (2018)
Journal Article
Meng, D., Li, X., Bauer, M., Taylor, J., Auer, D. P., & Alzheimer's Disease Neuroimaging Initiative. (2018). Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment. Radiology, 289(3), 775-785. https://doi.org/10.1148/radiol.2018180092

Purpose: To determine whether functional connectivity (FC) mapping of nucleus basalis of Meynert (NBM) cholinergic network (hereafter, NBM FC) could provide a biomarker of central cholinergic deficits with predictive potential for response to choline... Read More about Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment.

Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition (2018)
Journal Article
Chen, X., Low, K. H., Alexander, A., Jiang, Y., Karakas, C., Hess, K. R., …Keyomarsi, K. (2018). Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition. Clinical Cancer Research, https://doi.org/10.1158/1078-0432.ccr-18-1446

Purpose: Poor prognosis in triple-negative breast cancer (TNBC) is due to an aggressive phenotype and lack of biomarker-driven targeted therapies. Overexpression of cyclin E and phosphorylated-CDK2 are correlated with poor survival in TNBC patients,... Read More about Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition.

Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules (2018)
Journal Article
Clark, M. E., Bedford, L. E., Young, B., Robertson, J. F., das Nair, R., Vedhara, K., …Kendrick, D. (2018). Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules. Lung Cancer, 124, 160-167. https://doi.org/10.1016/j.lungcan.2018.08.001

Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population. Materials and methods: This... Read More about Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules.

Comorbidities are associated with poorer quality of life, functioning and worse symptoms in the 5 years following colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) cohort study (2018)
Journal Article
Cummings, A., Grimmett, C., Calman, L., Patel, M., Permyakova, N. V., Winter, J., …Foster, C. (2018). Comorbidities are associated with poorer quality of life, functioning and worse symptoms in the 5 years following colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) cohort study. Psycho-Oncology, 27(10), 2427-2435. https://doi.org/10.1002/pon.4845

© 2018 The Authors. Psycho-Oncology Published by John Wiley & Sons Ltd. Objective: More people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with... Read More about Comorbidities are associated with poorer quality of life, functioning and worse symptoms in the 5 years following colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) cohort study.

Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery (2018)
Journal Article
Kurien, T., Arendt-Nielsen, L., Petersen, K. K., Graven-Nielsen, T., & Scammell, B. E. (2018). Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery. Journal of Pain, doi:10.1016/j.jpain.2018.05.011. ISSN 1526-5900

Preoperative pain characteristics in osteoarthritis (OA) patients may explain persistent pain after total knee replacement (TKR). Fifty patients awaiting TKR and 22 asymptomatic controls were recruited to evaluate the degree of neuropathic pain sympt... Read More about Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery.

Evaluating the Care Certificate (ECCert): a cross-sector solution to assuring fundamental skills in caring (2018)
Report
Thomson, L., Argyle, E., Khan, Z., Schneider, J., Arthur, A., Maben, J., …Eve, J. (2018). Evaluating the Care Certificate (ECCert): a cross-sector solution to assuring fundamental skills in caring. Nottingham: Independent research

Using personalized teaching and learning to improve clinical performance (2018)
Journal Article
Sandars, J., & Patel, R. (2018). Using personalized teaching and learning to improve clinical performance. British Journal of Hospital Medicine, 79(2), 102-105. https://doi.org/10.12968/hmed.2018.79.2.102

The intention of personalized teaching and learning to improve clinical performance is the optimization of individual performance across a variety of tasks in different environments. Educational interventions need to have a focus on the assessment an... Read More about Using personalized teaching and learning to improve clinical performance.

Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885 (2018)
Journal Article
Shortall, S. E., Negm, O. H., Fowler, M., Fairclough, L. C., Tighe, P. J., Wigmore, P. M., & King, M. (2018). Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885. Molecular Neurobiology, 55(9), https://doi.org/10.1007/s12035-018-0940-0

Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT? receptor antagonist SB-399885 to reverse isolation-i... Read More about Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885.