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All Outputs (224)

Formation of staling aldehydes in different grain bed layers in an industrial scale maltings (2023)
Journal Article
Filipowska, W., Bauwens, J., Bolat, I., Cook, D., De Rouck, G., & De Cooman, L. (2023). Formation of staling aldehydes in different grain bed layers in an industrial scale maltings. Journal of the Institute of Brewing, 129(4), 276-306. https://doi.org/10.58430/jib.v129i4.34

Understanding the contribution of raw materials to the quality of the final product is crucial for the food industry. In the brewing process, malt delivers various compounds that compromise the flavour stability of beer, including staling aldehydes a... Read More about Formation of staling aldehydes in different grain bed layers in an industrial scale maltings.

The adaptability of the ion binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF (2023)
Journal Article
Lithgo, R. M., Hanževački, M., Harris, G., Kamps, J. J. .. G., Holden, E., Gianga, T.-M., Benesch, J. L., Jäger, C. M., Croft, A. K., Hussain, R., Hobman, J. L., Orville, A. M., Quigley, A., Carr, S. B., & Scott, D. J. (2023). The adaptability of the ion binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF. Journal of Biological Chemistry, 299(11), Article 105331. https://doi.org/10.1016/j.jbc.2023.105331

The periplasmic chaperone SilF has been identified as part of an Ag(I) detoxification system in Gram negative bacteria. Sil proteins also bind Cu(I), but with reported weaker affinity, therefore leading to the designation of a specific detoxification... Read More about The adaptability of the ion binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF.

Lateral interactions govern self-assembly of the bacterial biofilm matrix protein BslA (2023)
Journal Article
Arnaouteli, S., Bamford, N. C., Brandani, G. B., Morris, R. J., Schor, M., Carrington, J. T., Hobley, L., van Aalten, D. M. F., Stanley-Wall, N. R., & MacPhee, C. E. (2023). Lateral interactions govern self-assembly of the bacterial biofilm matrix protein BslA. Proceedings of the National Academy of Sciences, 120(45), Article e2312022120. https://doi.org/10.1073/pnas.2312022120

The soil bacterium Bacillus subtilis is a model organism to investigate the formation of biofilms, the predominant form of microbial life. The secreted protein BslA self-assembles at the surface of the biofilm to give the B. subtilis biofilm its char... Read More about Lateral interactions govern self-assembly of the bacterial biofilm matrix protein BslA.

Combining isotope ratios for provenancing Viking Age iron artefacts in the British Isles: a pilot study (2023)
Journal Article
Harding, S. E., Jones, C., Evans, J., Milot, J., Cutajar, M., Bailey, E., Pashley, V., Wagner, D., Halkon, P., & Pearce, M. (2023). Combining isotope ratios for provenancing Viking Age iron artefacts in the British Isles: a pilot study. RSC Advances, 13(44), 31292-31302. https://doi.org/10.1039/D3RA06367D

Stable and radiogenic isotope analysis – particularly using lead isotope analysis (LIA) - has previously been shown to be a useful tool for the provenancing of ancient metal artefacts of silver and copper and its alloys, but less progress has been ma... Read More about Combining isotope ratios for provenancing Viking Age iron artefacts in the British Isles: a pilot study.

A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment (2023)
Journal Article
Todman, H., Arya, S., Baker, M., & Stekel, D. J. (2023). A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment. PLoS ONE, 18(8), Article e0289941. https://doi.org/10.1371/journal.pone.0289941

Antimicrobial resistant bacterial infections represent one of the most serious contemporary global healthcare crises. Acquisition and spread of resistant infections can occur through community, hospitals, food, water or endogenous bacteria. Global ef... Read More about A model of antibiotic resistance genes accumulation through lifetime exposure from food intake and antibiotic treatment.

Quorum-sensing, intra- and inter-species competition in the staphylococci (2023)
Journal Article
Williams, P., Hill, P., Bonev, B., & Chan, W. C. (2023). Quorum-sensing, intra- and inter-species competition in the staphylococci. Microbiology, 169(8), https://doi.org/10.1099/mic.0.001381

In Gram-positive bacteria such as Staphylococcus aureus and the coagulase-negative staphylococci (CoNS), the accessory gene regulator (agr) is a highly conserved but polymorphic quorum-sensing system involved in colonization, virulence and biofilm de... Read More about Quorum-sensing, intra- and inter-species competition in the staphylococci.

Experimental support for reclassification of the light scattering second virial coefficient from macromolecular solutions as a hydrodynamic parameter (2023)
Journal Article
Winzor, D. J., Dinu, V., Scott, D. J., & Harding, S. E. (2023). Experimental support for reclassification of the light scattering second virial coefficient from macromolecular solutions as a hydrodynamic parameter. European Biophysics Journal, 52, 343–352. https://doi.org/10.1007/s00249-023-01665-w

This investigation examines the source of the disparity between experimental values of the light scattering second virial coefficient A2 (mL.mol/g2) for proteins and those predicted on the statistical mechanical basis of excluded volume. A much bette... Read More about Experimental support for reclassification of the light scattering second virial coefficient from macromolecular solutions as a hydrodynamic parameter.

Comparative hydrodynamic and nanoscale imaging study on the interactions of teicoplanin-A2 and bovine submaxillary mucin as a model ocular mucin (2023)
Journal Article
Chun, T., Pattem, J., Gillis, R. B., Dinu, V. T., Yakubov, G. E., Corfield, A. P., & Harding, S. E. (2023). Comparative hydrodynamic and nanoscale imaging study on the interactions of teicoplanin-A2 and bovine submaxillary mucin as a model ocular mucin. Scientific Reports, 13, Article 11367. https://doi.org/10.1038/s41598-023-38036-6

Glycopeptide antibiotics are regularly used in ophthalmology to treat infections of Gram-positive bacteria. Aggregative interactions of antibiotics with mucins however can lead to long exposure and increases the risk of resistant species. This study... Read More about Comparative hydrodynamic and nanoscale imaging study on the interactions of teicoplanin-A2 and bovine submaxillary mucin as a model ocular mucin.

Bayesian and ultrasonic sensor aided multi-objective optimisation for sustainable clean-in-place processes (2023)
Journal Article
Bowler, A. L., Rodgers, S., Cook, D. J., & Watson, N. J. (2023). Bayesian and ultrasonic sensor aided multi-objective optimisation for sustainable clean-in-place processes. Food and Bioproducts Processing, 141, 23-35. https://doi.org/10.1016/j.fbp.2023.06.010

In food and drink manufacturing, clean-in-place procedures are essential for hygienic and efficient operations but often over-clean process equipment leading to unnecessary use of energy, water, and chemicals. Previous attempts in the literature to o... Read More about Bayesian and ultrasonic sensor aided multi-objective optimisation for sustainable clean-in-place processes.

Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships (2023)
Journal Article
Myers, B., Catrambone, F., Allen, S., Hill, P. J., Kovacs, K., & Rawson, F. J. (2023). Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships. Scientific Reports, 13(1), Article 8843. https://doi.org/10.1038/s41598-023-35553-2

Bacterial pilin nanowires are protein complexes, suggested to possess electroactive capabilities forming part of the cells’ bioenergetic programming. Their role is thought to be linked to facilitating electron transfer between cells and the external... Read More about Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships.

Phage ZCSS1 from isolation to application against Staphylococcus sciuri and biofilm: A prospect of utilizing temperate phage and its products (2023)
Journal Article
Makky, S., Abdelsattar, A. S., Habashy, M., Dawoud, A., Nofal, R., Hassan, A., Connerton, I. F., & El-Shibiny, A. (2023). Phage ZCSS1 from isolation to application against Staphylococcus sciuri and biofilm: A prospect of utilizing temperate phage and its products. Gene Reports, 32, Article 101792. https://doi.org/10.1016/j.genrep.2023.101792

Following the spread of the multi-drug resistant bacteria and the huge demand on public health, various alternatives were pursued. Bacteriophages (virulent phages) are among the potential antibacterial agents that have shown promising applications in... Read More about Phage ZCSS1 from isolation to application against Staphylococcus sciuri and biofilm: A prospect of utilizing temperate phage and its products.

Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics (2023)
Journal Article
Chio, H., Guest, E. E., Hobman, J. L., Dottorini, T., Hirst, J. D., & Stekel, D. J. (2023). Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics. Journal of Molecular Graphics and Modelling, 123, Article 108508. https://doi.org/10.1016/j.jmgm.2023.108508

Antibiotics enter the environment through waste streams, where they can exert selective pressure for antimicrobial resistance in bacteria. However, many antibiotics are excreted as partly metabolized forms, or can be subject to partial breakdown in w... Read More about Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics.

Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi (2023)
Journal Article
Mikolajek, H., Sanchez-Weatherby, J., Sandy, J., Gildea, R. J., Campeotto, I., Cheruvara, H., Clarke, J. D., Foster, T., Fujii, S., Paulsen, I. T., Shah, B. S., & Hough, M. A. (2023). Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi. IUCrJ, 10(4), 420-429. https://doi.org/10.1107/s2052252523003810

The utility of X-ray crystal structures determined under ambient-temperature conditions is becoming increasingly recognized. Such experiments can allow protein dynamics to be characterized and are particularly well suited to challenging protein targe... Read More about Protein-to-structure pipeline for ambient-temperature in situ crystallography at VMXi.

Evolution: The great photosynthesis heist (2023)
Journal Article
Howe, C. J., & Nisbet, R. E. R. (2023). Evolution: The great photosynthesis heist. Current Biology, 33(5), R185-R187. https://doi.org/10.1016/j.cub.2023.01.030

Many eukaryotes acquired chloroplasts by endosymbiotic acquisition of photosynthetic bacteria or already-domesticated chloroplasts from other eukaryotes. However, the ciliate Mesodinium rubrum acquires the nucleus of a photosynthetic eukaryote, as we... Read More about Evolution: The great photosynthesis heist.

Evaluation of two terpene-derived polymers as consolidants for archaeological wood (2023)
Journal Article
Cutajar, M., Braovac, S., Stockman, R. A., Howdle, S. M., & Harding, S. E. (2023). Evaluation of two terpene-derived polymers as consolidants for archaeological wood. Scientific Reports, 13(1), Article 3664. https://doi.org/10.1038/s41598-023-29785-5

The evaluation of two terpene-derived polymers, termed TPA6 and TPA7, as possible consolidants for archaeological wood was carried out. The overall objective of this work was to expand the non-aqueous treatment toolkit which is available for the cons... Read More about Evaluation of two terpene-derived polymers as consolidants for archaeological wood.

Understanding Early Modern Beer: An Interdisciplinary Case-Study (2023)
Journal Article
Flavin, S., Meltonville, M., Taverner, C., Reid, J., Lawrence, S., Belloch-Molina, C., & Morrissey, J. (2023). Understanding Early Modern Beer: An Interdisciplinary Case-Study. Historical Journal, 66(3), 516-549. https://doi.org/10.1017/S0018246X23000043

Beer was a staple of early modern diets across northern Europe and the Atlantic World. While its profound social, economic, and cultural significance is well established, little is known about the nature and quality of the drink itself, particularly... Read More about Understanding Early Modern Beer: An Interdisciplinary Case-Study.

Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting (2023)
Journal Article
Lee, A., Liang, L., Connerton, P. L., Connerton, I. F., & Mellits, K. H. (2023). Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting. Frontiers in Veterinary Science, 10, Article 1118302. https://doi.org/10.3389/fvets.2023.1118302

Introduction: Rotavirus A is a major cause of acute dehydrating diarrhea in neonatal pigs resulting in significant mortality, morbidity, reduced performance and economic loss. Commercially available prebiotic galacto-oligosaccharides are similar to t... Read More about Galacto-oligosaccharides fed during gestation increase Rotavirus A specific antibodies in sow colostrum, modulate the microbiome, and reduce infectivity in neonatal piglets in a commercial farm setting.

eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation (2023)
Journal Article
Schmidt, T., Dabrowska, A., Waldron, J. A., Hodge, K., Koulouras, G., Gabrielsen, M., Munro, J., Tack, D. C., Harris, G., McGhee, E., Scott, D., Carlin, L., Huang, D., Le Quesne, J., Zanivan, S., Wilczynska, A., & Bushell, M. (2023). eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research, 51(4), 1859-1879. https://doi.org/10.1093/nar/gkad030

Altered eIF4A1 activity promotes translation of highly structured, eIF4A1-dependent oncogene mRNAs at root of oncogenic translational programmes. It remains unclear how these mRNAs recruit and activate eIF4A1 unwinding specifically to facilitate thei... Read More about eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.