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All Outputs (107)

Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity? (2018)
Journal Article
Rowland, S. C., Hartley, D. E. H., & Wiggins, I. M. (2018). Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity?. Trends in Hearing, 22, 1-18. https://doi.org/10.1177/2331216518804116

Listening to speech in the noisy conditions of everyday life can be effortful, reflecting the increased cognitive workload involved in extracting meaning from a degraded acoustic signal. Studying the underlying neural processes has the potential to p... Read More about Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity?.

Early discharge and rehabilitation in paediatric acquired brain and neurological injury: a transferable model (2018)
Journal Article
Keetley, R., Kelly, L., Whitehouse, W. P., Thomas, S., Bennett, E., Chow, G., Fletcher, A., & Williams, J. (2018). Early discharge and rehabilitation in paediatric acquired brain and neurological injury: a transferable model. Archives of Disease in Childhood.education and Practice Edition, https://doi.org/10.1136/archdischild-2018-315096

Children and young people who require rehabilitation following sustaining an acquired brain injury often experience long lengths of stay (LOS) and potentially poorer recovery outcomes due to limited access to therapy and little proactive discharge pl... Read More about Early discharge and rehabilitation in paediatric acquired brain and neurological injury: a transferable model.

Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006) (2018)
Journal Article
Wilde, C., Poostchi, A., Mehta, R. L., Hillman, J. G., MacNab, H. K., Messina, M., Monaco, G., Vernon, S. A., & Amoaku, W. M. (2019). Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006). Eye, 33(3), 451-458. https://doi.org/10.1038/s41433-018-0232-y

© 2018, The Royal College of Ophthalmologists. Purpose: There is paucity of data on the epidemiology of peripapillary choroidal neovascularisartion (PPCNV). Our aim was to determine prevalence of PPCNV in the elderly UK population of Bridlington res... Read More about Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006).

MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (2018). MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis. European Radiology Experimental, 2, Article 26. https://doi.org/10.1186/s41747-018-0056-3

Background: To use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (C... Read More about MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis.

Extending the Human Connectome Project across ages: imaging protocols for the Lifespan Development and Aging projects (2018)
Journal Article
Harms, M. P., Somerville, L. H., Ances, B. M., Andersson, J., Barch, D. M., Bastiani, M., Bookheimer, S. Y., Brown, T. B., Buckner, R. L., Burgess, G. C., Coalson, T. S., Chappell, M. A., Dapretto, M., Douaud, G., Fischl, B., Glasser, M. F., Greve, D. N., Hodge, C., Jamison, K. W., Jbabdi, S., …Yacoub, E. (2018). Extending the Human Connectome Project across ages: imaging protocols for the Lifespan Development and Aging projects. NeuroImage, 183, 972-984. https://doi.org/10.1016/j.neuroimage.2018.09.060

The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult
(HCP-YA) project to nearly the full lifespan, collecting structural, resting-sta... Read More about Extending the Human Connectome Project across ages: imaging protocols for the Lifespan Development and Aging projects.

Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors (2018)
Journal Article
Servante, J., Estranero, J., Meijer, L., Layfield, R., & Grundy, R. (2018). Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors. Oncotarget, 9(81), 35266-35277. https://doi.org/10.18632/oncotarget.26186

Brain tumors are the leading cause of cancer-related death in children and are the most challenging childhood cancer in relation to diagnosis, treatment, and outcome. One potential novel strategy to improve outcomes in cancer involves the manipulati... Read More about Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors.

Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells (2018)
Journal Article
Alkhattabi, N., Todd, I., Negm, O., Tighe, P. J., & Fairclough, L. C. (2018). Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells. Toxicology Letters, 299, 40-46. https://doi.org/10.1016/j.toxlet.2018.09.002

Cigarette smoke has significant toxic effects on the immune system, and increases the risk of developing autoimmune diseases; one immunosuppressive effect of cigarette smoke is that it inhibits the T cell-stimulating, immunogenic properties of myeloi... Read More about Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells.

The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing (2018)
Journal Article
Labisso, W., Raulin, A.-C., Nwidu, L., Kocon, A., Wayne, D., Erdozain, A., Morentin, B., Schwendener, D., Allen, G., Enticott, J., Gerdes, H., Johnson, L., Grzeskowiak, J., Drizou, F., Tarbox, R., Osna, N., Kharbanda, K., Callado, L., & Carter, W. (2018). The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing. Brain Sciences, 8(9), Article 175. https://doi.org/10.3390/brainsci8090175

Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human post-mortem tissue from Brodmann’s area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals w... Read More about The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing.

Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment (2018)
Journal Article
Meng, D., Li, X., Bauer, M., Taylor, J.-P., Auer, D. P., & Alzheimer's Disease Neuroimaging Initiative. (2018). Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment. Radiology, 289(3), 775-785. https://doi.org/10.1148/radiol.2018180092

Purpose: To determine whether functional connectivity (FC) mapping of nucleus basalis of Meynert (NBM) cholinergic network (hereafter, NBM FC) could provide a biomarker of central cholinergic deficits with predictive potential for response to choline... Read More about Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment.

Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition (2018)
Journal Article
Chen, X., Low, K. H., Alexander, A., Jiang, Y., Karakas, C., Hess, K. R., Carey, J. P., Bui, T., Vijayaraghavan, S., Evans, K. W., Yi, M., Ellis, D. C., Cheung, K.-L., Ellis, I. O., Fu, S., Meric-Bernstam, F., Hunt, K. K., & Keyomarsi, K. (2018). Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition. Clinical Cancer Research, https://doi.org/10.1158/1078-0432.ccr-18-1446

Purpose: Poor prognosis in triple-negative breast cancer (TNBC) is due to an aggressive phenotype and lack of biomarker-driven targeted therapies. Overexpression of cyclin E and phosphorylated-CDK2 are correlated with poor survival in TNBC patients,... Read More about Cyclin E overexpression sensitizes triple negative breast cancer to Wee1 kinase Inhibition.

Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules (2018)
Journal Article
Clark, M. E., Bedford, L. E., Young, B., Robertson, J. F., das Nair, R., Vedhara, K., Littleford, R., Sullivan, F. M., Mair, F. S., Schembri, S., Rauchhaus, P., & Kendrick, D. (2018). Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules. Lung Cancer, 124, 160-167. https://doi.org/10.1016/j.lungcan.2018.08.001

Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population.

Materials and methods: This... Read More about Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules.

Comorbidities are associated with poorer quality of life, functioning and worse symptoms in the 5 years following colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) cohort study (2018)
Journal Article
Cummings, A., Grimmett, C., Calman, L., Patel, M., Permyakova, N. V., Winter, J., Corner, J., Din, A., Fenlon, D., Richardson, A., Smith, P. W., & Foster, C. (2018). Comorbidities are associated with poorer quality of life, functioning and worse symptoms in the 5 years following colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) cohort study. Psycho-Oncology, 27(10), 2427-2435. https://doi.org/10.1002/pon.4845

© 2018 The Authors. Psycho-Oncology Published by John Wiley & Sons Ltd. Objective: More people are living with the consequences of cancer and comorbidity. We describe frequencies of comorbidities in a colorectal cancer cohort and associations with... Read More about Comorbidities are associated with poorer quality of life, functioning and worse symptoms in the 5 years following colorectal cancer surgery: results from the ColoREctal Wellbeing (CREW) cohort study.

Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery (2018)
Journal Article
Kurien, T., Arendt-Nielsen, L., Petersen, K. K., Graven-Nielsen, T., & Scammell, B. E. (2018). Preoperative neuropathic pain like symptoms and central pain mechanisms in knee osteoarthritis predicts poor outcome 6 months after total knee replacement surgery. Journal of Pain, https://doi.org/10.1016/j.jpain.2018.05.011

Using personalized teaching and learning to improve clinical performance (2018)
Journal Article
Sandars, J., & Patel, R. (2018). Using personalized teaching and learning to improve clinical performance. British Journal of Hospital Medicine, 79(2), 102-105. https://doi.org/10.12968/hmed.2018.79.2.102

The intention of personalized teaching and learning to improve clinical performance is the optimization of individual performance across a variety of tasks in different environments. Educational interventions need to have a focus on the assessment an... Read More about Using personalized teaching and learning to improve clinical performance.

Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885 (2018)
Journal Article
Shortall, S. E., Negm, O. H., Fowler, M., Fairclough, L. C., Tighe, P. J., Wigmore, P. M., & King, M. (2018). Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885. Molecular Neurobiology, 55(9), https://doi.org/10.1007/s12035-018-0940-0

Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT? receptor antagonist SB-399885 to reverse isolation-i... Read More about Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT6 receptor antagonist SB-399885.

Clinical interventions for hyperacusis in adults: a scoping review to assess the current position and determine priorities for research (2017)
Journal Article
Fackrell, K., Potgieter, I., Shekhawat, G. S., Baguley, D. M., Sereda, M., & Hoare, D. J. (2017). Clinical interventions for hyperacusis in adults: a scoping review to assess the current position and determine priorities for research. BioMed Research International, 2017, Article 2723715. https://doi.org/10.1155/2017/2723715

Background. There is no universally accepted definition for hyperacusis, but in general it is characterised by decreased sound tolerance to ordinary environmental sounds. Despite hyperacusis being prevalent and having significant clinical implication... Read More about Clinical interventions for hyperacusis in adults: a scoping review to assess the current position and determine priorities for research.

Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study (2017)
Journal Article
Lipnicki, D. M., Crawford, J. D., Dutta, R., Thalamuthu, A., Kochan, N. A., Andrews, G., Lima-Costa, M. F., Castro-Costa, E., Brayne, C., Matthews, F. E., Stephan, B. C. M., Lipton, R. B., Katz, M. J., Ritchie, K., Scali, J., Ancelin, M.-L., Scarmeas, N., Yannakoulia, M., Dardiotis, E., Lam, L. C. W., …Sachdev, P. S. (2017). Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. PLoS Medicine, 14(3), Article e1002261. https://doi.org/10.1371/journal.pmed.1002261