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Extending the Human Connectome Project across ages: imaging protocols for the Lifespan Development and Aging projects

Harms, Michael P.; Somerville, Leah H.; Ances, Beau M.; Andersson, Jesper; Barch, Deanna M.; Bastiani, Matteo; Bookheimer, Susan Y.; Brown, Timothy B.; Buckner, Randy L.; Burgess, Gregory C.; Coalson, Timothy S.; Chappell, Michael A.; Dapretto, Mirella; Douaud, Gwenaëlle; Fischl, Bruce; Glasser, Matthew F.; Greve, Douglas N.; Hodge, Cynthia; Jamison, Keith W.; Jbabdi, Saad; Kandala, Sridhar; Li, Xiufeng; Mair, Ross W.; Mangia, Silvia; Marcus, Daniel; Mascali, Daniele; Moeller, Steen; Nichols, Thomas E.; Robinson, Emma C.; Salat, David H.; Smith, Stephen M.; Sotiropoulos, Stamatios N.; Terpstra, Melissa; Thomas, Kathleen M.; Dylan Tisdall, M.; Ugurbil, Kamil; van der Kouwe, Andre; Woods, Roger P.; Zöllei, Lilla; Van Essen, David C.; Yacoub, Essa


Michael P. Harms

Leah H. Somerville

Beau M. Ances

Jesper Andersson

Deanna M. Barch

Matteo Bastiani

Susan Y. Bookheimer

Timothy B. Brown

Randy L. Buckner

Gregory C. Burgess

Timothy S. Coalson

Michael A. Chappell

Mirella Dapretto

Gwenaëlle Douaud

Bruce Fischl

Matthew F. Glasser

Douglas N. Greve

Cynthia Hodge

Keith W. Jamison

Saad Jbabdi

Sridhar Kandala

Xiufeng Li

Ross W. Mair

Silvia Mangia

Daniel Marcus

Daniele Mascali

Steen Moeller

Thomas E. Nichols

Emma C. Robinson

David H. Salat

Stephen M. Smith

Melissa Terpstra

Kathleen M. Thomas

M. Dylan Tisdall

Kamil Ugurbil

Andre van der Kouwe

Roger P. Woods

Lilla Zöllei

David C. Van Essen

Essa Yacoub


The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult
(HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100+ years of age. HCP-D is enrolling 1300+ healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200+ healthy adults (ages 36-100+), with each study collecting longitudinal data in a subset of individuals at particular age ranges. The imaging protocols of the HCP-D and HCP-A studies are very similar, differing primarily in the selection of different task-fMRI paradigms. We strove to harmonize the imaging protocol to the greatest extent feasible with the completed HCP-YA (1200+ participants, aged 22-35), but some imaging-related changes were motivated or necessitated by hardware changes, the need to reduce the total amount of scanning per participant, and/or the additional challenges of working with young and elderly populations. Here, we provide an overview of the common HCP-D/A imaging protocol including data and rationales for protocol decisions and changes relative to HCP-YA. The result will be a large, rich, multi-modal, and freely available set of consistently acquired data for use by the scientific community to investigate and define normative developmental and aging related changes in the healthy human brain.


Harms, M. P., Somerville, L. H., Ances, B. M., Andersson, J., Barch, D. M., Bastiani, M., …Yacoub, E. (2018). Extending the Human Connectome Project across ages: imaging protocols for the Lifespan Development and Aging projects. NeuroImage, 183, (972-984). doi:10.1016/j.neuroimage.2018.09.060. ISSN 1095-9572

Journal Article Type Article
Acceptance Date Sep 20, 2018
Online Publication Date Sep 24, 2018
Publication Date 2018-12
Deposit Date Sep 24, 2018
Publicly Available Date Sep 25, 2019
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 183
Pages 972-984
Keywords connectomics, resting-state, functional connectivity, task, diffusion, perfusion, development, aging, lifespan
Public URL
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