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Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors

Servante, Juliette; Estranero, Jasper; Meijer, Lisethe; Layfield, Rob; Grundy, Richard

Authors

Juliette Servante

Jasper Estranero

Lisethe Meijer

RICHARD GRUNDY richard.grundy@nottingham.ac.uk
Professor of Paediatric Neuro-Oncology



Abstract

Brain tumors are the leading cause of cancer-related death in children and are the most challenging childhood cancer in relation to diagnosis, treatment, and outcome. One potential novel strategy to improve outcomes in cancer involves the manipulation of autophagy, a fundamental process in all cells. In cancer, autophagy can be thought of as having a “Janus”-like duality. On one face, especially in the early phases of cancer formation, autophagy can act as a cellular housekeeper to eliminate damaged organelles and recycle macromolecules, thus acting as tumor suppressor. On the other face, at later stages of tumor progression, autophagy can function as a pro-survival pathway in response to metabolic stresses such as nutrient depravation, hypoxia and indeed to chemotherapy itself, and can support cell growth by supplying much needed energy. In the context of chemotherapy, autophagy may, in some cases, mediate resistance to treatment. We present an overview of the relevance of autophagy in central nervous system tumors including how its chemical modulation can serve as a useful adjunct to chemotherapy, and use this knowledge to consider how targeting of autophagy may be relevant in pediatric brain tumors.

Journal Article Type Article
Publication Date Oct 16, 2018
Journal Oncotarget
Electronic ISSN 1949-2553
Publisher Impact Journals
Peer Reviewed Peer Reviewed
Volume 9
Issue 81
Pages 35266-35277
APA6 Citation Servante, J., Estranero, J., Meijer, L., Layfield, R., & Grundy, R. (2018). Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors. Oncotarget, 9(81), 35266-35277. doi:10.18632/oncotarget.26186
DOI https://doi.org/10.18632/oncotarget.26186
Keywords Oncology
Publisher URL http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=26186

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