All Outputs (259)

The development of spicules in Heligmosomoides bakeri (Nematoda, Heligmosomidae) (2021)
Journal Article
Musah-Eroje, M., Burton, L., & Behnke, J. M. (2021). The development of spicules in Heligmosomoides bakeri (Nematoda, Heligmosomidae). Journal of Helminthology, 95, Article e45. https://doi.org/10.1017/S0022149X21000304

The spicules of male parasitic nematodes are key morphological features, which vary between species in shape and length and are used often for species identification. However, little is known about spicules and particularly if/how their length varies... Read More about The development of spicules in Heligmosomoides bakeri (Nematoda, Heligmosomidae).

Design and Evaluation of New Quinazolin-4(3 H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa (2021)
Journal Article
Soukarieh, F., Mashabi, A., Richardson, W., Oton, E. V., Romero, M., Roberston, S. N., Grossman, S., Sou, T., Liu, R., Halliday, N., Kukavica-Ibrulj, I., Levesque, R. C., Bergstrom, C. A. S., Kellam, B., Emsley, J., Heeb, S., Williams, P., Stocks, M. J., & Cámara, M. (2021). Design and Evaluation of New Quinazolin-4(3 H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa. ACS Infectious Diseases, 7(9), 2666-2685. https://doi.org/10.1021/acsinfecdis.1c00175

P. aeruginosa (PA) continues to pose a threat to global public health due to its high levels of antimicrobial resistance (AMR). The ongoing AMR crisis has led to an alarming shortage of effective treatments for resistant microbes, and hence there is... Read More about Design and Evaluation of New Quinazolin-4(3 H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa.

Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles (2021)
Journal Article
Konečná, V., Bray, S., Vlček, J., Bohutínská, M., Požárová, D., Choudhury, R. R., Bollmann-Giolai, A., Flis, P., Salt, D. E., Parisod, C., Yant, L., & Kolář, F. (2021). Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles. Nature Communications, 12(1), Article 4979. https://doi.org/10.1038/s41467-021-25256-5

Relative contributions of pre-existing vs de novo genomic variation to adaptation are poorly understood, especially in polyploid organisms. We assess this in high resolution using autotetraploid Arabidopsis arenosa, which repeatedly adapted to toxic... Read More about Parallel adaptation in autopolyploid Arabidopsis arenosa is dominated by repeated recruitment of shared alleles.

Identification of aroma compounds in a commonly prescribed oral nutritional supplement and associated changes in olfactory abilities with human ageing (2021)
Journal Article
Lester, S., Cornacchia, L., Corbier, C., Taylor, M. A., Ayed, C., Yang, N., Lim, M., Linforth, R., & Fisk, I. (2021). Identification of aroma compounds in a commonly prescribed oral nutritional supplement and associated changes in olfactory abilities with human ageing. Scientific Reports, 11(1), Article 16518. https://doi.org/10.1038/s41598-021-95915-6

Undernutrition is prevalent in the older adult population. Oral nutritional supplements (ONS) are a clinically effective nutritional intervention, however, patient acceptance of ONS can be limited by their palatability. While sensory attributes such... Read More about Identification of aroma compounds in a commonly prescribed oral nutritional supplement and associated changes in olfactory abilities with human ageing.

Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020 (2021)
Journal Article
Seehra, J. K., Lewis-Lloyd, C., Koh, A., Theophilidou, E., Daliya, P., Adiamah, A., & Lobo, D. N. (2021). Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020. World Journal of Surgery, 45(11), 3266-3277. https://doi.org/10.1007/s00268-021-06268-0

Background: Presentation at academic conferences is an important marker of research productivity. However, not all accepted abstracts progress to full publication, and there is anecdotal evidence suggesting an imbalance in sex and ethnicity amongst p... Read More about Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020.

Associations of changes in reported and estimated protein and energy intake with changes in insulin resistance, glycated hemoglobin, and BMI during the PREVIEW lifestyle intervention study (2021)
Journal Article
Drummen, M., Adam, T. C., Macdonald, I. A., Jalo, E., Larssen, T. M., Martinez, J. A., Handjiev-Darlenska, T., Brand-Miller, J., Poppitt, S. D., Stratton, G., Pietiläinen, K. H., Taylor, M. A., Navas-Carretero, S., Handjiev, S., Muirhead, R., Silvestre, M. P., Swindell, N., Huttunen-Lenz, M., Schlicht, W., Lam, T., …Westerterp-Plantenga, M. S. (2021). Associations of changes in reported and estimated protein and energy intake with changes in insulin resistance, glycated hemoglobin, and BMI during the PREVIEW lifestyle intervention study. American Journal of Clinical Nutrition, 114(5), 1847-1858. https://doi.org/10.1093/ajcn/nqab247

Background
Observed associations of high-protein diets with changes in insulin resistance are inconclusive.

Objectives
We aimed to assess associations of changes in both reported and estimated protein (PRep; PEst) and energy intake (EIRep; EIE... Read More about Associations of changes in reported and estimated protein and energy intake with changes in insulin resistance, glycated hemoglobin, and BMI during the PREVIEW lifestyle intervention study.

Sex differences in physical and mental health following highintensity interval training in adults with cardiovascular disease who completed cardiac rehabilitation (2021)
Journal Article
Vidal-Almela, S., Way, K. L., Terada, T., Tulloch, H. E., Keast, M.-L., Pipe, A. L., Chirico, D., & Reed, J. L. (2022). Sex differences in physical and mental health following highintensity interval training in adults with cardiovascular disease who completed cardiac rehabilitation. Applied Physiology, Nutrition, and Metabolism, 47(1), 9-17. https://doi.org/10.1139/apnm-2021-0265

This pre-post study examined sex-differences in peak aerobic power (V̇O2peak) and physical- and mental-health outcomes in adults with cardiovascular disease who completed high-intensity interval training (HIIT)-based cardiac rehabilitation. HIIT cons... Read More about Sex differences in physical and mental health following highintensity interval training in adults with cardiovascular disease who completed cardiac rehabilitation.

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial (2021)
Journal Article
Liu, X., Shaw, R. H., Stuart, A. S. V., Greenland, M., Aley, P. K., Andrews, N. J., Cameron, J. C., Charlton, S., Clutterbuck, E. A., Collins, A. M., Dinesh, T., England, A., Faust, S. N., Ferreira, D. M., Finn, A., Green, C. A., Hallis, B., Heath, P. T., Hill, H., Lambe, T., …Allen, L. (2021). Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial. Lancet, 398(10303), 856-869. https://doi.org/10.1016/S0140-6736%2821%2901694-9

Background: Use of heterologous prime-boost COVID-19 vaccine schedules could facilitate mass COVID-19 immunisation. However, we have previously reported that heterologous schedules incorporating an adenoviral vectored vaccine (ChAdOx1 nCoV-19, AstraZ... Read More about Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial.

The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors (2021)
Journal Article
Proudman, R. G. W., & Baker, J. G. (2021). The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors. Pharmacology Research and Perspectives, 9(4), Article e00799. https://doi.org/10.1002/prp2.799

Highly selective drugs offer a way to minimize side-effects. For agonist ligands, this could be through highly selective affinity or highly selective efficacy, but this requires careful measurements of intrinsic efficacy. The α1-adrenoceptors are imp... Read More about The selectivity of α‐adrenoceptor agonists for the human α1A, α1B, and α1D‐adrenoceptors.

Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection (2021)
Journal Article
Urbanowicz, R. A., Tsoleridis, T., Jackson, H. J., Cusin, L., Duncan, J. D., Chappell, J. G., Tarr, A. W., Nightingale, J., Norrish, A. R., Ikram, A., Marson, B., Craxford, S. J., Kelly, A., Aithal, G. P., Vijay, A., Tighe, P. J., Ball, J. K., Valdes, A. M., & Ollivere, B. J. (2021). Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection. Science Translational Medicine, 13(609), Article eabj0847. https://doi.org/10.1126/scitranslmed.abj0847

Understanding the impact of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the response to vaccination is a priority for responding to the coronavirus disease 2019 (COVID-19) pandemic. In particular, it is necess... Read More about Two doses of the SARS-CoV-2 BNT162b2 vaccine enhance antibody responses to variants in individuals with prior SARS-CoV-2 infection.

Microbial Metal Resistance within Structured Environments Is Inversely Related to Environmental Pore Size (2021)
Journal Article
Harvey, H. J., Mitzakoff, A. M., Wildman, R. D., Mooney, S. J., & Avery, S. V. (2021). Microbial Metal Resistance within Structured Environments Is Inversely Related to Environmental Pore Size. Applied and Environmental Microbiology, 87(20), Article e01005-21. https://doi.org/10.1128/AEM.01005-21

The physical environments in which microorganisms naturally reside rarely have homogeneous structure, and changes in their porous architecture may have effects on microbial activities that are not typically captured in conventional laboratory studies... Read More about Microbial Metal Resistance within Structured Environments Is Inversely Related to Environmental Pore Size.

Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans (2021)
Journal Article
Willis, C. R., Gallagher, I. J., Wilkinson, D. J., Brook, M. S., Bass, J. J., Phillips, B. E., Smith, K., Etheridge, T., Stokes, T., McGlory, C., Gorissen, S. H., Szewczyk, N. J., Phillips, S. M., & Atherton, P. J. (2021). Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans. FASEB Journal, 35(9), Article e21830. https://doi.org/10.1096/fj.202100276RR

Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates... Read More about Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.

SARS-CoV-2 reinfection in patients negative for immunoglobulin G following recovery from COVID-19 (2021)
Journal Article
Ali, A. M., Ali, K. M., Fatah, M. H., Tawfeeq, H. M., & Rostam, H. M. (2021). SARS-CoV-2 reinfection in patients negative for immunoglobulin G following recovery from COVID-19. New Microbes and New Infections, 43, Article 100926. https://doi.org/10.1016/j.nmni.2021.100926

While many patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) eventually produce neutralising antibodies, the degree of susceptibility of previously infected individuals to reinfection by SARS-CoV-2 is currently unknown... Read More about SARS-CoV-2 reinfection in patients negative for immunoglobulin G following recovery from COVID-19.

Solid state NMR of membrane proteins: Methods and applications (2021)
Journal Article
Yeh, V., & Bonev, B. B. (2021). Solid state NMR of membrane proteins: Methods and applications. Biochemical Society Transactions, 49(4), 1505-1513. https://doi.org/10.1042/BST20200070

Membranes of cells are active barriers, in which membrane proteins perform essential remodelling, transport and recognition functions that are vital to cells. Membrane proteins are key regulatory components of cells and represent essential targets fo... Read More about Solid state NMR of membrane proteins: Methods and applications.

Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1sub-unit (2021)
Journal Article
Soh, E. Y.-C., Smith, F., Gimenez, M. R., Yang, L., Vejborg, R. M., Fletcher, M., Halliday, N., Bleves, S., Heeb, S., Camara, M., Givskov, M., Hardie, K. R., Tolker-Nielsen, T., Ize, B., & Williams, P. (2021). Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1sub-unit. PLoS Pathogens, 17(8), Article e1009425. https://doi.org/10.1371/journal.ppat.1009425

Extracellular DNA (eDNA) is a major constituent of the extracellular matrix of Pseudomonas aeruginosa biofilms and its release is regulated via pseudomonas quinolone signal (PQS) dependent quorum sensing (QS). By screening a P. aeruginosa transposon... Read More about Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc1sub-unit.

Role of the renin–angiotensin–aldosterone and kinin–kallikrein systems in the cardiovascular complications of COVID-19 and long COVID (2021)
Journal Article
Cooper, S. L., Boyle, E., Jefferson, S. R., Heslop, C. R. A., Mohan, P., Mohanraj, G. G. J., Sidow, H. A., Tan, R. C. P., Hill, S. J., & Woolard, J. (2021). Role of the renin–angiotensin–aldosterone and kinin–kallikrein systems in the cardiovascular complications of COVID-19 and long COVID. International Journal of Molecular Sciences, 22(15), Article 8255. https://doi.org/10.3390/ijms22158255

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible for the COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to severe and life-threatening symptoms. Although COVID-19 has a respiratory foc... Read More about Role of the renin–angiotensin–aldosterone and kinin–kallikrein systems in the cardiovascular complications of COVID-19 and long COVID.

Prospective examination of mental health in university students during the COVID-19 pandemic (2021)
Preprint / Working Paper
Jia, R., Knight, H., Ayling, K., Coupland, C., Corner, J., Denning, C., Ball, J., Bolton, K., Morling, J. R., Figueredo, G., Morris, D. E., Tighe, P., Villalon, A., Blake, H., & Vedhara, K. Prospective examination of mental health in university students during the COVID-19 pandemic

Background The impact of changing social restrictions on the mental health of students during the COVID-19 pandemic warrants exploration.

Aims To prospectively examine changes to university students’ mental health during the pandemic.

Methods S... Read More about Prospective examination of mental health in university students during the COVID-19 pandemic.

Association of Psychobehavioral Variables With HOMA-IR and BMI Differs for Men and Women With Prediabetes in the PREVIEW Lifestyle Intervention (2021)
Journal Article
Adam, T. C., Drummen, M., Macdonald, I., Jalo, E., Siig-Vestentoft, P., Martinez, J. A., Handjiev-Darlenska, T., Brand-Miller, J., Poppitt, S., Stratton, G., Fogelholm, M., Pietiläinen, K. H., Taylor, M., Navas-Carretero, S., Winkens, B., Handjiev, S., Muirhead, R., Silvestre, M., Swindell, N., Huttunen-Lenz, M., …Westerterp-Plantenga, M. (2021). Association of Psychobehavioral Variables With HOMA-IR and BMI Differs for Men and Women With Prediabetes in the PREVIEW Lifestyle Intervention. Diabetes Care, 44(7), 1491-1498. https://doi.org/10.2337/dc21-0059

OBJECTIVE
Stress, sleep, eating behavior, and physical activity are associated with weight change and insulin resistance (IR). The aim of this analysis was the assessment of the overall and sex-specific associations of psychobehavioral variables th... Read More about Association of Psychobehavioral Variables With HOMA-IR and BMI Differs for Men and Women With Prediabetes in the PREVIEW Lifestyle Intervention.

What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes (2021)
Journal Article
Monteford, J., Bilverstone, T. W., Ingle, P., Philip, S., Kuehne, S. A., & Minton, N. P. (2021). What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes. Anaerobe, 71, Article 102422. https://doi.org/10.1016/j.anaerobe.2021.102422

Clostridioides difficile R20291 is the most studied PCR-Ribotype 027 isolate. The two predominant lineages of this hypervirulent strain, however, exhibit substantive phenotypic differences and possess genomes that differ by a small number of nucleoti... Read More about What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes.

Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP) (2021)
Journal Article
George, C. H., Alexander, S. P., Cirino, G., Insel, P. A., Izzo, A. A., Ji, Y., Kendall, D. A., Panettieri, R. A., Patel, H. H., Sobey, C. G., Stanford, S. C., Stefanska, B., Stephens, G., Teixeira, M., & Ahluwalia, A. (2021). Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). British Journal of Pharmacology, 178(18), 3605-3610. https://doi.org/10.1111/bph.15589