What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes

Monteford, Jorge; Bilverstone, Terry W.; Ingle, Patrick; Philip, Sheryl; Kuehne, Sarah A.; Minton, Nigel P.

Abstract

Clostridioides difficile R20291 is the most studied PCR-Ribotype 027 isolate. The two predominant lineages of this hypervirulent strain, however, exhibit substantive phenotypic differences and possess genomes that differ by a small number of nucleotide changes. It is important that the source of R20291 is taken into account in research outcomes.

Citation

Monteford, J., Bilverstone, T. W., Ingle, P., Philip, S., Kuehne, S. A., & Minton, N. P. (2021). What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes. Anaerobe, 71, Article 102422. https://doi.org/10.1016/j.anaerobe.2021.102422

• Journal Article Type: Article
• Acceptance Date: Jul 27, 2021
• Online Publication Date: Jul 31, 2021
• Publication Date: Oct 1, 2021
• Deposit Date: Aug 9, 2021
• Publicly Available Date: Aug 9, 2021
• Journal: Anaerobe
• Print ISSN: 1075-9964
• Electronic ISSN: 1095-8274
• Publisher: Elsevier BV
• Peer Reviewed: Peer Reviewed
• Volume: 71
• Article Number: 102422
• DOI: https://doi.org/10.1016/j.anaerobe.2021.102422
• Keywords: Infectious Diseases; Microbiology
• Public URL: https://nottingham-repository.worktribe.com/output/6009089
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1075996421001050?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes; Journal Title: Anaerobe; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.anaerobe.2021.102422; Content Type: article; Copyright: © 2021 The Authors. Published by Elsevier Ltd.