All Outputs (259)

Impact of isoenergetic intake of irregular meal patterns on thermogenesis, glucose metabolism, and appetite: a randomized controlled trial (2021)
Journal Article
Alhussain, M. H., Macdonald, I. A., & Taylor, M. A. (2022). Impact of isoenergetic intake of irregular meal patterns on thermogenesis, glucose metabolism, and appetite: a randomized controlled trial. American Journal of Clinical Nutrition, 115(1), 284-297. https://doi.org/10.1093/ajcn/nqab323

Background
Evidence is emerging that interdaily meal pattern variability potentially affects response such as thermic effect of food (TEF), macronutrient metabolism, and appetite.

Objectives
To investigate the effect of irregular meal pattern o... Read More about Impact of isoenergetic intake of irregular meal patterns on thermogenesis, glucose metabolism, and appetite: a randomized controlled trial.

Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model (2021)
Journal Article
Seldeslachts, L., Vanderbeke, L., Fremau, A., Reséndiz-Sharpe, A., Jacobs, C., Laeveren, B., Ostyn, T., Naesens, L., Brock, M., Van De Veerdonk, F. L., Humblet-Baron, S., Verbeken, E., Lagrou, K., Wauters, J., & Vande Velde, G. (2021). Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model. Virulence, 12(1), 2493-2508. https://doi.org/10.1080/21505594.2021.1974327

Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immunocompetent... Read More about Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model.

Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions (2021)
Journal Article
O’Toole, G. A., Crabbé, A., Kümmerli, R., LiPuma, J. J., Bomberger, J. M., Davies, J. C., Limoli, D., Phelan, V. V., Bliska, J. B., DePas, W. H., Dietrich, L. E., Hampton, T. H., Hunter, R., Khursigara, C. M., Price-Whelan, A., Ashare, A., Cramer, R. A., Goldberg, J. B., Harrison, F., Hogan, D. A., …Whiteson, K. (2021). Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions. mBio, 12(5), https://doi.org/10.1128/mbio.01763-21

A recent workshop titled “Developing Models to Study Polymicrobial Infections,” sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of pe... Read More about Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.

Mapping the evolution of accurate Batesian mimicry of social wasps in hoverflies (2021)
Journal Article
Leavey, A., Taylor, C. H., Symonds, M. R. E., Gilbert, F., & Reader, T. (2021). Mapping the evolution of accurate Batesian mimicry of social wasps in hoverflies. Evolution, https://doi.org/10.1111/evo.14336

Hoverflies (Diptera: Syrphidae) provide an excellent opportunity to study the evolution of Batesian mimicry, where defenseless prey avoid predation by evolving to resemble defended “model” species. Although some hoverflies beautifully resemble their... Read More about Mapping the evolution of accurate Batesian mimicry of social wasps in hoverflies.

Fragment evolution for GPCRs: The role of secondary binding sites in optimization (2021)
Journal Article
Chevillard, F., Kelemen, Á., Baker, J. G., Aranyodi, V. A., Balzer, F., Kolb, P., & Keserű, G. M. (2021). Fragment evolution for GPCRs: The role of secondary binding sites in optimization. Chemical Communications, 57(81), 10516-10519. https://doi.org/10.1039/d1cc04636e

We developed a docking-based fragment evolution approach that extends orthosteric fragments towards a less conserved secondary binding pocket of GPCRs. Evaluating 13 000 extensions for the β1- and β2-adrenergic receptors we synthesized and tested 112... Read More about Fragment evolution for GPCRs: The role of secondary binding sites in optimization.

The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis (2021)
Journal Article
Crossland, H., Constantin-Teodosiu, D., & Greenhaff, P. L. (2021). The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis. International Journal of Molecular Sciences, 22(18), 1-13. https://doi.org/10.3390/ijms22189775

The peroxisome proliferator-activated receptor (PPAR) family of transcription factors has been demonstrated to play critical roles in regulating fuel selection, energy expenditure and inflammation in skeletal muscle and other tissues. Activation of P... Read More about The Regulatory Roles of PPARs in Skeletal Muscle Fuel Metabolism and Inflammation: Impact of PPAR Agonism on Muscle in Chronic Disease, Contraction and Sepsis.

Novel detection of specific bacterial quorum sensing molecules in saliva: Potential non-invasive biomarkers for pulmonary Pseudomonas aeruginosa in cystic fibrosis (2021)
Journal Article
Webb, K., Cámara, M., Zain, N. M. M., Halliday, N., Bruce, K. D., Nash, E. F., Whitehouse, J. L., Knox, A., Forrester, D., Smyth, A. R., Williams, P., Fogarty, A., & Barr, H. L. (2022). Novel detection of specific bacterial quorum sensing molecules in saliva: Potential non-invasive biomarkers for pulmonary Pseudomonas aeruginosa in cystic fibrosis. Journal of Cystic Fibrosis, 21(4), 626-629. https://doi.org/10.1016/j.jcf.2021.08.030

Pseudomonas aeruginosa produces specific signalling molecules, 2-alkyl-4-quinolones (AQs) that are detectable in the sputum of adults with cystic fibrosis (CF) and who have pulmonary infection with this opportunistic pathogen. This study aimed to det... Read More about Novel detection of specific bacterial quorum sensing molecules in saliva: Potential non-invasive biomarkers for pulmonary Pseudomonas aeruginosa in cystic fibrosis.

Genetic Connectivity of Seamount Populations of Bluenose Warehou (Hyperoglyphe antarctica) (2021)
Journal Article
Heyworth, S. M., Bell, J. B., Wade, C. M., Cavalcante, G., Robinson, N., Young, E., Glass, J., & Feary, D. A. (2021). Genetic Connectivity of Seamount Populations of Bluenose Warehou (Hyperoglyphe antarctica). Frontiers in Marine Science, 8, Article 640504. https://doi.org/10.3389/fmars.2021.640504

Quantifying the level of population connectivity within and between geographically separated single-species deep-water fisheries stocks will be vital for designing effective management plans to preserve such populations. Despite this, stock structure... Read More about Genetic Connectivity of Seamount Populations of Bluenose Warehou (Hyperoglyphe antarctica).

The pMTL70000 modular, plasmid vector series for strain engineering in Cupriavidus necator H16 (2021)
Journal Article
Ehsaan, M., Baker, J., Kovács, K., Malys, N., & Minton, N. P. (2021). The pMTL70000 modular, plasmid vector series for strain engineering in Cupriavidus necator H16. Journal of Microbiological Methods, 189, Article 106323. https://doi.org/10.1016/j.mimet.2021.106323

Cupriavidus necator H16 can convert CO2 into industrial chemicals and fuels. To facilitate its engineering, we designed, built and tested the pMTL70000 modular plasmids comprising standardised Cupriavidus and E. coli replicons, selectable markers and... Read More about The pMTL70000 modular, plasmid vector series for strain engineering in Cupriavidus necator H16.

Species and Phenotypic Distribution Models Reveal Population Differentiation in Ethiopian Indigenous Chickens (2021)
Journal Article
Kebede, F. G., Komen, H., Dessie, T., Alemu, S. W., Hanotte, O., & Bastiaansen, J. W. (2021). Species and Phenotypic Distribution Models Reveal Population Differentiation in Ethiopian Indigenous Chickens. Frontiers in Genetics, 12, Article 723360. https://doi.org/10.3389/fgene.2021.723360

Smallholder poultry production dominated by indigenous chickens is an important source of livelihoods for most rural households in Ethiopia. The long history of domestication and the presence of diverse agroecologies in Ethiopia create unique opportu... Read More about Species and Phenotypic Distribution Models Reveal Population Differentiation in Ethiopian Indigenous Chickens.

CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity (2021)
Journal Article
Rusu, A. D., Cornhill, Z. E., Coutiño, B. C., Uribe, M. C., Lourdusamy, A., Markus, Z., May, S. T., Rahman, R., & Georgiou, M. (2021). CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity. Open Biology, 11(9), Article 210077. https://doi.org/10.1098/rsob.210077

Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established role... Read More about CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity.

Vinculin is required for neuronal mechanosensing but not for axon outgrowth (2021)
Journal Article
Wang, D. Y., Melero, C., Albaraky, A., Atherton, P., Jansen, K. A., Dimitracopoulos, A., Dajas-Bailador, F., Reid, A., Franze, K., & Ballestrem, C. (2021). Vinculin is required for neuronal mechanosensing but not for axon outgrowth. Experimental Cell Research, 407(2), Article 112805. https://doi.org/10.1016/j.yexcr.2021.112805

Integrin receptors are transmembrane proteins that bind to the extracellular matrix (ECM). In most animal cell types integrins cluster together with adaptor proteins at focal adhesions that sense and respond to external mechanical signals. In the cen... Read More about Vinculin is required for neuronal mechanosensing but not for axon outgrowth.

Historical maps confirm the accuracy of zero‐inflated model predictions of ancient tree abundance in English wood‐pastures (2021)
Journal Article
Nolan, V., Reader, T., Gilbert, F., & Atkinson, N. (2021). Historical maps confirm the accuracy of zero‐inflated model predictions of ancient tree abundance in English wood‐pastures. Journal of Applied Ecology, 58(11), 2661-2672. https://doi.org/10.1111/1365-2664.13996

Ancient trees have important ecological, historical and social connections, and are a key source of dead and decaying wood, a globally declining resource. Wood-pastures, which combine livestock grazing, open spaces and scattered trees, are significan... Read More about Historical maps confirm the accuracy of zero‐inflated model predictions of ancient tree abundance in English wood‐pastures.

Transposable element annotation in non‐model species: The benefits of species‐specific repeat libraries using semi‐automated EDTA and DeepTE de novo pipelines (2021)
Journal Article
Bell, E. A., Butler, C. L., Oliveira, C., Marburger, S., Yant, L., & Taylor, M. I. (2022). Transposable element annotation in non‐model species: The benefits of species‐specific repeat libraries using semi‐automated EDTA and DeepTE de novo pipelines. Molecular Ecology Resources, 22(2), 823-833. https://doi.org/10.1111/1755-0998.13489

Transposable elements (TEs) are significant genomic components which can be detected either through sequence homology against existing databases or de novo, with the latter potentially reducing the risk of underestimating TE abundance. Here, we descr... Read More about Transposable element annotation in non‐model species: The benefits of species‐specific repeat libraries using semi‐automated EDTA and DeepTE de novo pipelines.

Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review (2021)
Preprint / Working Paper
Gomez, N., James, V., Onion, D., & Fairclough, L. Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular Vesicles and Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review.

Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties (2021)
Journal Article
Nizamudeen, Z. A., Xerri, R., Parmenter, C., Suain, K., Markus, R., Chakrabarti, L., & Sottile, V. (2021). Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties. Cells, 10(9), Article 2413. https://doi.org/10.3390/cells10092413

Low-power sonication is widely used to disaggregate extracellular vesicles (EVs) after isolation, however, the effects of sonication on EV samples beyond dispersion are unclear. The present study analysed the characteristics of EVs collected from mes... Read More about Low-Power Sonication Can Alter Extracellular Vesicle Size and Properties.

Cytoplasmic long noncoding rnas are differentially regulated and translated during human neuronal differentiation (2021)
Journal Article
DOUKA, K., BIRDS, I., WANG, D., KOSTELETOS, A., CLAYTON, S., BYFORD, A., VASCONCELOS, E. J., O'CONNELL, M. J., DEUCHARS, J., WHITEHOUSE, A., & ASPDEN, J. L. (2021). Cytoplasmic long noncoding rnas are differentially regulated and translated during human neuronal differentiation. RNA, 27(9), 1082-1101. https://doi.org/10.1261/rna.078782.121

The expression of long noncoding RNAs is highly enriched in the human nervous system. However, the function of neuronal lncRNAs in the cytoplasm and their potential translation remains poorly understood. Here we performed Poly-Ribo-Seq to understand... Read More about Cytoplasmic long noncoding rnas are differentially regulated and translated during human neuronal differentiation.

Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) Using Combined High-Throughput Methods (2021)
Journal Article
Cuzzucoli Crucitti, V., Contreas, L., Taresco, V., Howard, S. C., Dundas, A. A., Limo, M. J., Nisisako, T., Williams, P. M., Williams, P., Alexander, M. R., Wildman, R. D., Muir, B. W., & Irvine, D. J. (2021). Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) Using Combined High-Throughput Methods. ACS Applied Materials and Interfaces, 13(36), 43290-43300. https://doi.org/10.1021/acsami.1c08662

We report the first successful combination of three distinct high-throughput techniques to deliver the accelerated design, synthesis, and property screening of a library of novel, bio-instructive, polymeric, comb-graft surfactants. These three-dimens... Read More about Generation and Characterization of a Library of Novel Biologically Active Functional Surfactants (Surfmers) Using Combined High-Throughput Methods.

Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity (2021)
Journal Article
Albogami, S., Todd, I., Negm, O., Fairclough, L. C., & Tighe, P. J. (2021). Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity. Immunology, 164(3), 637-654. https://doi.org/10.1111/imm.13400

The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine-rich domains (CRD) in their extracellular regions, and the membrane-distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a p... Read More about Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity.

Moving Together While Staying Apart: Practical Recommendations for 24-Hour Home-Based Movement Behaviours for Those With Cardiovascular Disease (2021)
Journal Article
O’Neill, C. D., Vidal-Almela, S., Terada, T., Way, K. L., Kamiya, K., Sperlich, B., Duking, P., Chaput, J.-P., Prince, S. A., Pipe, A. L., & Reed, J. L. (2021). Moving Together While Staying Apart: Practical Recommendations for 24-Hour Home-Based Movement Behaviours for Those With Cardiovascular Disease. CJC Open, 3(12), 1495-1504. https://doi.org/10.1016/j.cjco.2021.08.010

The novel coronavirus disease 2019 is a global public health crisis that disproportionately affects those with preexisting conditions. Cardiovascular disease (CVD) is the leading cause of death worldwide and many key CVD risk factors are modifiable (... Read More about Moving Together While Staying Apart: Practical Recommendations for 24-Hour Home-Based Movement Behaviours for Those With Cardiovascular Disease.