All Outputs (260)

Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease (2021)
Journal Article
Bourgognon, J.-M., Spiers, J. G., Robinson, S. W., Scheiblich, H., Glynn, P., Ortori, C., Bradley, S. J., Tobin, A. B., & Steinert, J. R. (2021). Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease. Proceedings of the National Academy of Sciences, 118(10), Article e2009579118. https://doi.org/10.1073/pnas.2009579118

Several neurodegenerative diseases associated with protein misfolding (Alzheimer’s and Parkinson’s disease) exhibit oxidative and nitrergic stress following initiation of neuroinflammatory pathways. Associated nitric oxide (NO)-mediated posttranslati... Read More about Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease.

The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation (2021)
Journal Article
Phelps, C. E., Lumb, B. M., Donaldson, L. F., & Robinson, E. S. (2021). The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation. PAIN, 162(3), 956-966. https://doi.org/10.1097/j.pain.0000000000002177

Chronic pain is highly comorbid with affective disorders, including major depressive disorder. A core feature of major depressive disorder is a loss of interest in previously rewarding activities. Major depressive disorder is also associated with ne... Read More about The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation.

Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip (2021)
Journal Article
Burroughs, L., Amer, M., Vassey, M., Koch, B., Figueredo, G., Mukonoweshuro, B., Mikulskis, P., Vasilevich, A., Vermeulen, S., Dryden, I. L., Winkler, D. A., Ghaemmaghami, A. M., Rose, F. R. A. J., de Boer, J., & Alexander, M. R. (2021). Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip. Biomaterials, 271, Article 120740. https://doi.org/10.1016/j.biomaterials.2021.120740

© 2021 The Authors Human mesenchymal stem cells (hMSCs) are widely represented in regenerative medicine clinical strategies due to their compatibility with autologous implantation. Effective bone regeneration involves crosstalk between macrophages an... Read More about Discovery of synergistic material-topography combinations to achieve immunomodulatory osteoinductive biomaterials using a novel in vitro screening method: The ChemoTopoChip.

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei (2021)
Journal Article
Davies, C., Ooi, C. P., Sioutas, G., Hall, B. S., Sidhu, H., Butter, F., Alsford, S., Wickstead, B., & Rudenko, G. (2021). TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei. Nucleic Acids Research, 49(6), 3242-3262. https://doi.org/10.1093/nar/gkab109

The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective variant surface glycoprotein (VSG) coat for survival in the mammalian host. A single trypanosome has >2000 VSG genes and pseudogenes of which only one... Read More about TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei.

Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients (2021)
Journal Article
Gillis, R. D., Botteri, E., Chang, A., Ziegler, A. I., Chung, N. C., Pon, C. K., Shackleford, D. M., Andreassen, B. K., Halls, M. L., Baker, J. G., & Sloan, E. K. (2021). Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients. European Journal of Cancer, 147, 106-116. https://doi.org/10.1016/j.ejca.2021.01.029

© 2021 Elsevier Ltd
Purpose: The sympathetic nervous system drives breast cancer progression through β-adrenergic receptor signalling. This discovery has led to the consideration of cardiac β-blocker drugs as novel strategies for anticancer therapi... Read More about Carvedilol blocks neural regulation of breast cancer progression in vivo and is associated with reduced breast cancer mortality in patients.

Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development (2021)
Journal Article
Derrick, C. J., Sánchez-Posada, J., Hussein, F., Tessadori, F., Pollitt, E. J. G., Savage, A. M., Wilkinson, R. N., Chico, T. J., van Eeden, F. J., Bakkers, J., & Noël, E. S. (2022). Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development. Cardiovascular Research, 118(1), 226-240. https://doi.org/10.1093/cvr/cvab004

Aims: Vertebrate heart development requires the complex morphogenesis of a linear tube to form the mature organ, a process essential for correct cardiac form and function, requiring coordination of embryonic laterality, cardiac growth, and regionaliz... Read More about Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development.

Genome-Wide Analysis of Targets for Post-Transcriptional Regulation by Rsm Proteins in Pseudomonas putida (2021)
Journal Article
Huertas-Rosales, Ó., Romero, M., Chan, K. G., Hong, K.-W., Camara, M., Heeb, S., Barrientos-Moreno, L., Molina-Henares, A. M., Travieso, M. L., Ramos, M., & Espinosa-Urgel, M. (2021). Genome-Wide Analysis of Targets for Post-Transcriptional Regulation by Rsm Proteins in Pseudomonas putida. Frontiers in Molecular Biosciences, 8, Article 624061. https://doi.org/10.3389/fmolb.2021.624061

© Copyright © 2021 Huertas-Rosales, Romero, Chan, Hong, Cámara, Heeb, Barrientos-Moreno, Molina-Henares, Travieso, Ramos-González and Espinosa-Urgel. Post-transcriptional regulation is an important step in the control of bacterial gene expression in... Read More about Genome-Wide Analysis of Targets for Post-Transcriptional Regulation by Rsm Proteins in Pseudomonas putida.

Adaptive introgression: how polyploidy reshapes gene flow landscapes (2021)
Journal Article
Schmickl, R., & Yant, L. (2021). Adaptive introgression: how polyploidy reshapes gene flow landscapes. New Phytologist, 230(2), 457-461. https://doi.org/10.1111/nph.17204

© 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation Rare yet accumulating evidence in both plants and animals shows that whole genome duplication (WGD, leading to polyploidy) can break down reproductive barriers, facilitating gene f... Read More about Adaptive introgression: how polyploidy reshapes gene flow landscapes.

Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements (2021)
Journal Article
Hamed, A., Todd, I., Tighe, P. J., Powell, R. J., Harrison, T., & Fairclough, L. (2021). Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements. Journal of Immunological Methods, 492, Article 112999. https://doi.org/10.1016/j.jim.2021.112999

© 2021 Elsevier B.V. Skin prick testing (SPT) and measurement of serum allergen-specific IgE (sIgE) are used to investigate asthma and other allergic conditions. Measurement of serum total IgE (tIgE) and allergen-specific IgG4 (sIgG4) may also be use... Read More about Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements.

Influence of environmental and genetic factors on food protein quality: current knowledge and future directions (2021)
Journal Article
Szepe, K. J., Dyer, P. S., Johnson, R. I., Salter, A. M., & Avery, S. V. (2021). Influence of environmental and genetic factors on food protein quality: current knowledge and future directions. Current Opinion in Food Science, 40, 94-101. https://doi.org/10.1016/j.cofs.2021.02.005

© 2021 Elsevier Ltd Dietary protein quality is commonly defined by the bioavailability of essential amino acids, a function of amino acid composition and protein digestibility. This review assesses the potential for manipulation of amino acid composi... Read More about Influence of environmental and genetic factors on food protein quality: current knowledge and future directions.

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture (2021)
Journal Article
Shakkottai, V. G., Goldstein, D. S., Gan-Or, Z., Flanagan, M. E., Sidransky, E., The American Genome Center, Sabir, M. S., Reynolds, R. H., Walton, R. L., Makarious, M. B., Portley, M. K., Hernandez, D. G., Blauwendraat, C., Stone, D. J., Eicher, J., Parkkinen, L., Ansorge, O., Clark, L., Londos, E., Honig, L. S., …Morgan, K. (2021). Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature Genetics, 53, 294-303. https://doi.org/10.1038/s41588-021-00785-3

The genetic basis of Lewy body dementia (LBD) is not well understood. Here, we
performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy
controls to study the genetic architecture of this understudied form of deme... Read More about Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture.

Growth impacts in a changing ocean: insights from two coral reef fishes in an extreme environment (2021)
Journal Article
D'Agostino, D., Burt, J. A., Santinelli, V., Vaughan, G. O., Fowler, A., Reader, T., Taylor, B. M., Hoey, A. S., Cavalcante, G. H., Bauman, A. G., & Feary, D. A. (2021). Growth impacts in a changing ocean: insights from two coral reef fishes in an extreme environment. Coral Reefs, 40(2), 433–446. https://doi.org/10.1007/s00338-021-02061-6

Determining the life history consequences for fishes living in extreme and variable environments will be vital in predicting the likely impacts of ongoing climate change on reef fish demography. Here, we compare size-at-age and maximum body size of t... Read More about Growth impacts in a changing ocean: insights from two coral reef fishes in an extreme environment.

Function of the pseudo phosphotransfer proteins has diverged between rice and Arabidopsis (2021)
Journal Article
Vaughan-Hirsch, J., Tallerday, E. J., Burr, C. A., Hodgens, C., Louise Boeshore, S., Beaver, K., Melling, A., Sari, K., Kerr, I. D., Šimura, J., Ljung, K., Xu, D., Liang, W., Bhosale, R., Eric Schaller, G., Bishopp, A., & Kieber, J. J. (2021). Function of the pseudo phosphotransfer proteins has diverged between rice and Arabidopsis. Plant Journal, 106(1), 159-173. https://doi.org/10.1111/tpj.15156

© 2021 The Authors. The Plant Journal published by Society for Experimental Biology and John Wiley & Sons Ltd. The phytohormone cytokinin plays a significant role in nearly all aspects of plant growth and development. Cytokinin signaling has primar... Read More about Function of the pseudo phosphotransfer proteins has diverged between rice and Arabidopsis.

Comparison of the behavior of fungal and plant cell wall during gastrointestinal digestion and resulting health effects: A review (2021)
Journal Article
Colosimo, R., Warren, F. J., Edwards, C. H., Ryden, P., Dyer, P. S., Finnigan, T. J., & Wilde, P. J. (2021). Comparison of the behavior of fungal and plant cell wall during gastrointestinal digestion and resulting health effects: A review. Trends in Food Science and Technology, 110, 132-141. https://doi.org/10.1016/j.tifs.2021.02.001

Background; The structure of many plant- and fungal-based foods is determined by cell walls which are the primary source of dietary fiber. Several studies have shown that consumption of cell wall fibers from plants and fungi can modulate digestion le... Read More about Comparison of the behavior of fungal and plant cell wall during gastrointestinal digestion and resulting health effects: A review.

Priorities for social science and humanities research on the challenges of moving beyond animal-based food systems (2021)
Journal Article
Morris, C., Kaljonen, M., Aavik, K., Balázs, B., Cole, M., Coles, B., Efstathiu, S., Fallon, T., Foden, M., Haifa Giraud, E., Goodman, M., Hadley Kershaw, E., Helliwell, R., Hobson-West, P., Häyry, M., Jallinoja, P., Jones, M., Kaarlenkaski, T., Laihonen, M., Lähteenmäki-Uutela, A., …White, R. (2021). Priorities for social science and humanities research on the challenges of moving beyond animal-based food systems. Humanities and Social Sciences Communications, 8, Article 38. https://doi.org/10.1057/s41599-021-00714-z

Increasingly high-profile research is being undertaken into the socio-environmental challenges associated with the over-production and consumption of food from animals. Transforming food systems to mitigate climate change and hidden hunger, ensure fo... Read More about Priorities for social science and humanities research on the challenges of moving beyond animal-based food systems.

Immunity in space: prokaryote adaptations and immune response in microgravity (2021)
Journal Article
Green, M. J., Aylott, J. W., Williams, P., Ghaemmaghami, A. M., & Williams, P. M. (2021). Immunity in space: prokaryote adaptations and immune response in microgravity. Life, 11(2), Article 112. https://doi.org/10.3390/life11020112

Immune dysfunction has long been reported by medical professionals regarding astronauts suffering from opportunistic infections both during their time in space and a short period afterwards once back on Earth. Various species of prokaryotes onboard t... Read More about Immunity in space: prokaryote adaptations and immune response in microgravity.

Colonisation factor cd0873, an attractive oral vaccine candidate against clostridioides difficile (2021)
Journal Article
Karyal, C., Hughes, J., Kelly, M. L., Cockayne, A., Luckett, J. C., Kaye, P. V., Minton, N. P., & Griffin, R. (2021). Colonisation factor cd0873, an attractive oral vaccine candidate against clostridioides difficile. Microorganisms, 9(2), Article 306. https://doi.org/10.3390/microorganisms9020306

Clostridioides difficile is the main cause of health-care-associated infectious diarrhoea. Toxins, TcdA and TcdB, secreted by this bacterium damage colonic epithelial cells and in severe cases this culminates in pseudomembranous colitis, toxic megaco... Read More about Colonisation factor cd0873, an attractive oral vaccine candidate against clostridioides difficile.

Courtship behavior, nesting microhabitat, and assortative mating in sympatric stickleback species pairs (2021)
Journal Article
Dean, L. L., Dunstan, H. R., Reddish, A., & MacColl, A. D. C. (2021). Courtship behavior, nesting microhabitat, and assortative mating in sympatric stickleback species pairs. Ecology and Evolution, 11(4), 1741-1755. https://doi.org/10.1002/ece3.7164

© 2021 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. The maintenance of reproductive isolation in the face of gene flow is a particularly contentious topic, but differences in reproductive behavior may provide the key to ex... Read More about Courtship behavior, nesting microhabitat, and assortative mating in sympatric stickleback species pairs.

Varadia, a new helicarionoidean semi-slug genus from India’s Western ghats (Stylommatophora: Helicarionoidea) (2021)
Journal Article
Bhosale, A. R., Saadi, A. J., Wade, C. M., Thackeray, T. U., Tamboli, A. S., Kadam, S. K., Muley, D. V., & Raheem, D. C. (2021). Varadia, a new helicarionoidean semi-slug genus from India’s Western ghats (Stylommatophora: Helicarionoidea). European Journal of Taxonomy, 757, 50-79. https://doi.org/10.5852/ejt.2021.757.1413

We here describe a new Indian helicarionoidean genus, Varadia Bhosale & Raheem gen. nov., containing the single species Varadia amboliensis Bhosale, Thackeray, Muley & Raheem gen. et sp. nov. This new semi-slug is endemic to the northern and central... Read More about Varadia, a new helicarionoidean semi-slug genus from India’s Western ghats (Stylommatophora: Helicarionoidea).

Detection of genome-edited and endogenously expressed G protein-coupled receptors (2021)
Journal Article
Soave, M., Stoddart, L. A., White, C. W., Kilpatrick, L. E., Goulding, J., Briddon, S. J., & Hill, S. J. (2021). Detection of genome-edited and endogenously expressed G protein-coupled receptors. FEBS Journal, 288(8), 2585-2601. https://doi.org/10.1111/febs.15729

© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and major targets for FDA-approved d... Read More about Detection of genome-edited and endogenously expressed G protein-coupled receptors.