All Outputs (22)

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article

Objective To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventin... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

Ultra-high surface area ionic-liquid-derived carbons that meet both gravimetric and volumetric methane storage targets (2024)
Journal Article

The storage of methane, to enable vehicular use, may be achieved in porous solids, but to date, there is no material that meets the gravimetric and volumetric targets (for example those set by the US Department of Energy, DOE) for such use. Here, in... Read More about Ultra-high surface area ionic-liquid-derived carbons that meet both gravimetric and volumetric methane storage targets.

Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study (2024)
Journal Article

Objective The uptake and safety of pneumococcal vaccination in people with immune mediated inflammatory diseases (IMIDs) is poorly understood. We investigated the UK wide pneumococcal vaccine uptake in adults with IMIDs and explored the association b... Read More about Uptake and safety of pneumococcal vaccination in adults with immune mediated inflammatory diseases: a UK wide observational study.

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients (2024)
Journal Article

Viral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days of SARS-CoV-2 symptoms randomised to receive molnupiravir (n=253) or Usual Care (n... Read More about Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients.

Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial (2023)
Journal Article

Background Methotrexate is the first-line treatment for immune-mediated inflammatory diseases and reduces vaccine-induced immunity. We evaluated if a 2-week interruption of methotrexate treatment immediately after COVID-19 booster vaccination improv... Read More about Two-week break in methotrexate treatment and COVID-19 vaccine response: a prospective, open label, two-arm parallel-group, multicentre, superiority, randomised controlled trial.

Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable (2023)
Journal Article

INTRODUCTION: Influenza causes significant morbidity and mortality, but influenza vaccine uptake remains below most countries' targets. Vaccine policy recommendations vary, as do procedures for reviewing and appraising the evidence. AREAS COVERED: Du... Read More about Real world evidence for public health decision-making on vaccination policies: perspectives from an expert roundtable.

Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity (2023)
Journal Article

Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the S/F ratio. Because of the... Read More about Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.

Synthesis and Characterization of Doped Magnesium Hydroxide for Medium Heat Storage Application (2023)
Journal Article

The amount of waste heat generated annually in the UK exceeds the total annual electricity demand. Hence, it is crucial to effectively harness all available sources of waste heat based on their varying temperatures. Through suitable technologies, a s... Read More about Synthesis and Characterization of Doped Magnesium Hydroxide for Medium Heat Storage Application.

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease (2023)
Journal Article

Introduction: There is an urgent need to determine the safety, effectiveness and cost-effectiveness of novel antiviral treatments for COVID-19 in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19. Met... Read More about Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease.

A simple, sustainable route to flexible microporous carbon cloth for energy storage applications (2023)
Journal Article

Activated carbon cloth (ACC) has the potential to be extremely useful in gas capture and storage applications as it combines high porosity, robustness, and flexibility with ease of handling. While it has been produced by a few researchers, the synthe... Read More about A simple, sustainable route to flexible microporous carbon cloth for energy storage applications.

Solvothermal synthesis of organoclay/Cu-MOF composite and its application in film modified GCE for simultaneous electrochemical detection of deoxyepinephrine, acetaminophen and tyrosine (2023)
Journal Article

An organoclay/copper-based metal-organic framework (MOF) composite was synthesized using a solvothermal method by growing a Cu-BTC (copper(ii) benzene-1,3,5-tricarboxylate) MOF from a mixture of the MOF precursor solution in which various amounts of... Read More about Solvothermal synthesis of organoclay/Cu-MOF composite and its application in film modified GCE for simultaneous electrochemical detection of deoxyepinephrine, acetaminophen and tyrosine.

Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study (2023)
Journal Article

Objectives To derive and validate risk prediction algorithms (QCOVID4) to estimate the risk of covid-19 related death and hospital admission in people with a positive SARS-CoV-2 test result during the period when the omicron variant of the virus was... Read More about Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.

Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial (2023)
Journal Article

Background: This was the first study to investigate the reactogenicity and immunogenicity of heterologous or fractional second dose COVID-19 vaccine regimens in adolescents. Methods: A phase II, single-blind, multi-centre, randomised-controlled trial... Read More about Reactogenicity, immunogenicity and breakthrough infections following heterologous or fractional second dose COVID-19 vaccination in adolescents (Com-COV3): A randomised controlled trial.

Hydrothermal synthesis of zeolites using silica extracted from tropical volcanic ash (2023)
Journal Article

This study addresses the reliance on costly aluminosilicate sources for the synthesis of zeolites by exploring the use of silica extracted from tropical volcanic ash. The volcanic ash contained CaO, in the form of calcite polymorph of CaCO3, and sili... Read More about Hydrothermal synthesis of zeolites using silica extracted from tropical volcanic ash.

Changing water quality and thermocline depth along an aquaculture gradient in six tropical crater lakes (2022)
Journal Article

Understanding how lakes respond to changes in nutrient loading along a productivity gradient can help identify key drivers of aquatic change, thereby allowing appropriate mitigation strategies to be developed. Physical, chemical and biological water... Read More about Changing water quality and thermocline depth along an aquaculture gradient in six tropical crater lakes.

How well do crop modeling groups predict wheat phenology, given calibration data from the target population? (2021)
Journal Article

© 2020 Elsevier B.V. Predicting phenology is essential for adapting varieties to different environmental conditions and for crop management. Therefore, it is important to evaluate how well different crop modeling groups can predict phenology. Multipl... Read More about How well do crop modeling groups predict wheat phenology, given calibration data from the target population?.

Supportive care needs of patients following treatment for colorectal cancer: risk factors for unmet needs and the association between unmet needs and health-related quality of life—results from the ColoREctal Wellbeing (CREW) study (2019)
Journal Article

Purpose To investigate unmet needs of patients with colorectal cancer (CRC) at the end of treatment and whether unmet needs improve over time. Identify predictors of need following treatment and whether unmet need is associated with worse health-r... Read More about Supportive care needs of patients following treatment for colorectal cancer: risk factors for unmet needs and the association between unmet needs and health-related quality of life—results from the ColoREctal Wellbeing (CREW) study.

Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration (2019)
Journal Article

Currently, there is no effective long-term treatment for intervertebral disc degeneration (IVDD), making it an attractive candidate for regenerative therapies. Hydrogel delivery of adipose stem cells (ASCs) in combination with controlled release of b... Read More about Microparticles for controlled GDF6 delivery to direct ASC?based nucleus pulposus regeneration.

Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds (2019)
Journal Article

Tissue engineering response may be tailored via controlled, sustained release of active agents from protein loaded degradable microparticles incorporated directly within 3D ice-templated collagen scaffolds. However, the effects of covalent crosslink... Read More about Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds.

Functional Outcomes and Health-Related Quality of Life After Curative Treatment for Rectal Cancer: A Population-Level Study in England (2018)
Journal Article

Purpose There is a growing population of cancer survivors at risk of treatment-related morbidity. This study investigated how potentially curative rectal cancer treatment influences subsequent function and health-related quality of life using data f... Read More about Functional Outcomes and Health-Related Quality of Life After Curative Treatment for Rectal Cancer: A Population-Level Study in England.