All Outputs (181)

Long-term psychological outcomes following stroke: the OX-CHRONIC study (2023)
Journal Article
Kusec, A., Milosevich, E., Williams, O. A., Chiu, E. G., Watson, P., Carrick, C., …Demeyere, N. (2023). Long-term psychological outcomes following stroke: the OX-CHRONIC study. BMC Neurology, 23, Article 426. https://doi.org/10.1186/s12883-023-03463-5

Background Stroke survivors rate longer-term (> 2 years) psychological recovery as their top priority, but data on how frequently psychological consequences occur is lacking. Prevalence of cognitive impairment, depression/anxiety, fatigue, apathy... Read More about Long-term psychological outcomes following stroke: the OX-CHRONIC study.

Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop (2023)
Journal Article
Witham, M. D., Bridges, J., Gladman, J., Gordon, A. L., Kay, S., Manthorpe, J., …Sayer, A. A. (2023). Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop. Clinical Medicine Journal, 23(6), 611-614. https://doi.org/10.7861/clinmed.2023-0389

High-quality care for older people is best delivered by multidisciplinary teams involving a range of professions. Similarly, if research evidence is to effectively inform practice, it needs to be designed and executed by teams that are both multidisc... Read More about Spotlight on the academic multidisciplinary team: proposals from the 3rd NIHR Newcastle BRC Academic Geriatric Medicine Workshop.

Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery (2023)
Journal Article
Wilmington, R., Ardavani, A., Simenacz, A., Green, C., & Idris, I. (2024). Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery. Obesity Surgery, 34, 286-289. https://doi.org/10.1007/s11695-023-06895-7

Objective The effectiveness of liraglutide 3.0 mg (Saxenda) therapy to induce weight loss among obese patients prior to bariatric surgery remains uncertain. Methods Clinical data was retrospectively obtained from patients with prediabetes (HbA1c... Read More about Liraglutide 3.0mg (Saxenda©) for weight loss and remission of pre-diabetes. Real- world clinical evaluation of effectiveness among patients awaiting bariatric surgery.

Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts (2023)
Journal Article
Wei, J., Yang, Z., Li, J., Zhang, Y., Zhang, W., Doherty, M., …Zeng, C. (2023). Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts. EBioMedicine, 98, Article 104892. https://doi.org/10.1016/j.ebiom.2023.104892

Background: Since gut microbiome dysbiosis can cause inflammatory disorders by affecting host metabolism, we postulate that the gut microbiome and related metabolites could play a role in hand osteoarthritis. We characterised gut microbiome-related m... Read More about Association between gut microbiome-related metabolites and symptomatic hand osteoarthritis in two independent cohorts.

Osteoarthritis pain phenotypes: How best to cut the cake? (2023)
Journal Article
Smith, S. L., & Walsh, D. A. (2023). Osteoarthritis pain phenotypes: How best to cut the cake?. Osteoarthritis and Cartilage, Article S1063-4584(23)00986-X. https://doi.org/10.1016/j.joca.2023.11.008

Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial (2023)
Journal Article
Richards, D. A., Bollen, J., Jones, B., Melendez-Torres, G. J., Hulme, C., Cockcroft, E., …Wootton, S. (2024). Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial. Journal of Advanced Nursing, 80(5), 2137-2152. https://doi.org/10.1111/jan.15959

Aim: To evaluate the impact of usual care plus a fundamental nursing care guideline compared to usual care only for patients in hospital with COVID‐19 on patient experience, care quality, functional ability, treatment outcomes, nurses' moral distress... Read More about Evaluation of a COVID‐19 fundamental nursing care guideline versus usual care: The COVID‐NURSE cluster randomized controlled trial.

How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey (2023)
Journal Article
Prior, J. A., Roddy, E., Solis-Trapala, I., Cornwall, N., Jinks, C., Abhishek, A., …Hider, S. (2023). How do clinicians prescribe bridging glucocorticoids in people starting or escalating disease-modifying anti-rheumatic drugs for rheumatoid arthritis: a service evaluation survey. Rheumatology Advances in Practice, 7(3), Article rkad102. https://doi.org/10.1093/rap/rkad102

The metabolic effects of intermittent versus continuous feeding in critically ill patients (2023)
Journal Article
Wilkinson, D., Gallagher, I. J., McNelly, A., Bear, D. E., Hart, N., Montgomery, H. E., …Puthucheary, Z. A. (2023). The metabolic effects of intermittent versus continuous feeding in critically ill patients. Scientific Reports, 13(1), Article 19508. https://doi.org/10.1038/s41598-023-46490-5

Intermittent (or bolus) feeding regimens in critically ill patients have been of increasing interest to clinicians and scientists. Changes in amino acid, fat and carbohydrate metabolites over time might yet deliver other benefits (e.g. modulation of... Read More about The metabolic effects of intermittent versus continuous feeding in critically ill patients.

Data Collection in Care Homes for Older Adults: A National Survey in England (2023)
Journal Article
Hanratty, B., Wolters, A. T., Towers, A. M., Spilsbury, K., Meyer, J., Killett, A., …Goodman, C. (2023). Data Collection in Care Homes for Older Adults: A National Survey in England. Journal of Long-Term Care, 2023, 288-296. https://doi.org/10.31389/jltc.199

Context: In many countries, there is a specification for information that should be collected by care homes. So-called ‘minimum data-sets’ (MDS) are often lengthy, and report on resident health and wellbeing, staff, and facilities. In the UK, the abs... Read More about Data Collection in Care Homes for Older Adults: A National Survey in England.

Whether from a position of strength or weakness, geriatric medicine has work to do to drive up standards in health care for older people (2023)
Journal Article
Gordon, A. L., Martin, F., Mistry, S., Harwood, R. H., & Dhesi, J. (2023). Whether from a position of strength or weakness, geriatric medicine has work to do to drive up standards in health care for older people. Age and Ageing, 52(11), Article afad208. https://doi.org/10.1093/ageing/afad208

• Geriatric medicine is the largest physicianly specialty in the UK, with high levels of competition for available training posts. • Improving care of older people has been the focus of multiple national policy initiatives in the UK over the past dec... Read More about Whether from a position of strength or weakness, geriatric medicine has work to do to drive up standards in health care for older people.

The Web-Based Pain-at-Work Toolkit With Telephone Support for Employees With Chronic or Persistent Pain: Protocol for a Cluster Randomized Feasibility Trial (2023)
Journal Article
Blake, H., Chaplin, W., Wainwright, E., Taylor, G., McNamee, P., McWilliams, D., …Walker-Bone, K. (2023). The Web-Based Pain-at-Work Toolkit With Telephone Support for Employees With Chronic or Persistent Pain: Protocol for a Cluster Randomized Feasibility Trial. JMIR Research Protocols, 12, Article e51474. https://doi.org/10.2196/51474

Background: Chronic or persistent pain affects people’s ability to work or be productive at work, generating high societal and economic burden. However, the provision of work-related advice and support for people with chronic pain is variable or lack... Read More about The Web-Based Pain-at-Work Toolkit With Telephone Support for Employees With Chronic or Persistent Pain: Protocol for a Cluster Randomized Feasibility Trial.

Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study (2023)
Journal Article
Thompson, W., Swain, S., Zhao, S. S., Kamps, A., Coupland, C., Kuo, C., …Zhang, W. (2023). Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study. Osteoarthritis and Cartilage Open, 5(4), Article 100414. https://doi.org/10.1016/j.ocarto.2023.100414

Objective To investigate the causal association between Osteoarthritis (OA) and five comorbidities: depression, tiredness, multisite chronic pain, irritable bowel syndrome (IBS) and gout.... Read More about Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study.

Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned? (2023)
Journal Article
Cipolletta, E., Moscioni, E., Sirotti, S., Di Battista, J., Abhishek, A., Rozza, D., …Filippucci, E. (2023). Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned?. Rheumatology, https://doi.org/10.1093/rheumatology/kead565

Objective To develop the optimal US scanning protocol for the diagnosis of CPPD disease. Methods In this cross-sectional study, consecutive patients with a crystal-proven diagnosis of CPPD disease, and age-, sex-matched disease controls and... Read More about Diagnosis of calcium pyrophosphate crystal deposition disease by ultrasonography: how many and which sites should be scanned?.

Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function (2023)
Journal Article
Piasecki, J., Guo, Y., Jones, E. J., Phillips, B. E., Stashuk, D. W., Atherton, P. J., & Piasecki, M. (2023). Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function. Sports Medicine - Open, 9, Article 97. https://doi.org/10.1186/s40798-023-00639-8

Background: Estrogen and progesterone are the primary female sex hormones and have net excitatory and inhibitory effects, respectively, on neuronal function. Fluctuating concentrations across the menstrual cycle has led to several lines of research i... Read More about Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function.

Identifying and Managing Frailty: A Survey of UK Healthcare Professionals (2023)
Journal Article
Frost, R., Robinson, K., Gordon, A., Caldeira de Melo, R., Villas-Boas, P. J. F., Azevedo, P. S., …Gavin, J. P. (2024). Identifying and Managing Frailty: A Survey of UK Healthcare Professionals. Journal of Applied Gerontology, 43(4), 402-412. https://doi.org/10.1177/07334648231206321

Frailty is a common condition that leads to multiple adverse outcomes. Frailty should be identified and managed in a holistic, evidence-based and patient-centered way. We aimed to understand how UK healthcare professionals (HCPs) identify and manage... Read More about Identifying and Managing Frailty: A Survey of UK Healthcare Professionals.

The student patient alliance: development and formative evaluation of an initiative to support collaborations between patient and public involvement partners and doctoral students (2023)
Journal Article
Simons, G., Birch, R., Stocks, J., Insch, E., Rijckborst, R., Neag, G., …Falahee, M. (2023). The student patient alliance: development and formative evaluation of an initiative to support collaborations between patient and public involvement partners and doctoral students. BMC Rheumatology, 7(1), Article 36. https://doi.org/10.1186/s41927-023-00359-2

Background While the integration of patient and public involvement (PPI) in clinical research is now widespread and recommended as standard practice, meaningful PPI in pre-clinical, discovery science research is more difficult to achieve. One potent... Read More about The student patient alliance: development and formative evaluation of an initiative to support collaborations between patient and public involvement partners and doctoral students.

Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women (2023)
Journal Article
MALLINSON, J., WARDLE, S., O'LEARY, T., GREEVES, J., CEGIELSKI, J., BASS, J., …GREENHAFF, P. (2023). Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women. Scandinavian Journal of Medicine and Science in Sports, 33(12), 2470-2481. https://doi.org/10.1111/sms.14506

Studies examining the effect of protein (PRO) feeding on post resistance exercise (RE) muscle protein synthesis (MPS) have primarily been performed in men, and little evidence is available regarding the quantity of PRO required to maximally stimulate... Read More about Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women.

ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial (2023)
Journal Article
Rossios, C., Bashir, T., Achison, M., Adamson, S., Akpan, A., Aspray, T., …Kemp, P. R. (2023). ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial. PLoS ONE, 18(10), Article e0292402. https://doi.org/10.1371/journal.pone.0292402

Background: Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial was designed... Read More about ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia: Results from the LACE trial.

Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort (2023)
Journal Article
McWilliams, D. F., Yue, B., Smith, S. L., Stocks, J., Doherty, M., Valdes, A. M., …Walsh, D. A. (2023). Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort. Journal of Personalized Medicine, 13(10), Article 1450. https://doi.org/10.3390/jpm13101450

Knee pain is associated with lower muscle strength, and both contribute to disability. Peripheral and central neurological mechanisms contribute to OA pain. Understanding the relative contributions of pain mechanisms to muscle strength might help fut... Read More about Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.

Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study (2023)
Journal Article
Bishop, S., Narayanasamy, M. J., Paskins, Z., Corp, N., Bastounis, A., Griffin, J., …Sahota, O. (2023). Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study. BMC Musculoskeletal Disorders, 24, Article 770. https://doi.org/10.1186/s12891-023-06865-1

Background Bisphosphonate medications, including alendronate, ibandronate and risedronate administered orally and zoledronate, administered intravenously, are commonly prescribed for the treatment of osteoporosis based on evidence that, correctly tak... Read More about Clinicians’ views of prescribing oral and intravenous bisphosphonates for osteoporosis: a qualitative study.