All Outputs (163)

Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke (2023)
Journal Article
Rakkar, K., Othman, O. A., Sprigg, N., Bath, P. M., & Bayraktutan, U. (2023). Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke. Stem Cell Reviews and Reports, 19(6), 1856-1869. https://doi.org/10.1007/s12015-023-10544-y

Ageing impairs endothelial function and predisposes the person to ischaemic stroke (IS). Endothelial progenitor cells (EPCs) repair endothelial damage and induce post-ischaemic neovascularisation. Given the prevalence of IS in older population, this... Read More about Evaluation of Endothelial Progenitor Cell Characteristics as Clinical Biomarkers for Elderly Patients with Ischaemic Stroke.

Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II (2023)
Journal Article
Begde, A., Jain, M., Goodwin, M., Brayne, C., Barnes, L., Brooks, R., …Hogervorst, E. (2024). Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II. Information, Communication and Society, 27(2), 368-385. https://doi.org/10.1080/1369118X.2023.2205915

Technology is widely promoted as a solution to greater independence and better health for the rapidly growing UK older population. If this is to be realised, we need to understand barriers and facilitators to uptake and investigate who wants this tec... Read More about Exploring factors influencing willingness of older adults to use assistive technologies: evidence from the cognitive function and ageing study II.

We need timely access to mental health data: implications of the Goldacre review (2023)
Journal Article
Astle, D. E., Moore, A., Marryat, L., Viding, E., Mansfield, K. L., Fazel, M., …Ford, T. J. (2023). We need timely access to mental health data: implications of the Goldacre review. Lancet Psychiatry, 10(4), 242-244. https://doi.org/10.1016/S2215-0366%2823%2900030-5

The Goldacre review, published in April, 2022, 1 is a landmark evaluation of the use, availability, and safety of National Health Service (NHS) data across all four nations of the UK. The review underscores the necessary role of data in driving healt... Read More about We need timely access to mental health data: implications of the Goldacre review.

Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment (2023)
Journal Article
Deacon, S., Dalleywater, W., Peat, C., Paine, S. M., & Dineen, R. A. (2024). Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment. Cerebellum, 23(2), 502-511. https://doi.org/10.1007/s12311-023-01560-2

Cerebellar neurodegeneration is a classical feature of ataxia telangiectasia (A-T), an autosomal recessive condition caused by loss-of-function mutation of the ATM gene, a gene with multiple regulatory functions. The increased vulnerability of cerebe... Read More about Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment.

Endovascular Thrombectomy Versus Best Medical Management Beyond 24 Hours From Last Known Well in Acute Ischemic Stroke Due to Large Vessel Occlusion (2023)
Journal Article
Dhillon, P. S., Butt, W., Jovin, T. G., Podlasek, A., McConachie, N., Lenthall, R., …England, T. J. (2023). Endovascular Thrombectomy Versus Best Medical Management Beyond 24 Hours From Last Known Well in Acute Ischemic Stroke Due to Large Vessel Occlusion. Stroke: Vascular and Interventional Neurology, 3(5), Article e000790. https://doi.org/10.1161/svin.122.000790

BACKGROUND The safety and efficacy of endovascular thrombectomy (EVT) in patients with acute ischemic stroke due to large vessel occlusion presenting beyond 24 hours from last known well (LKW) remains undetermined. METHODS In this single center... Read More about Endovascular Thrombectomy Versus Best Medical Management Beyond 24 Hours From Last Known Well in Acute Ischemic Stroke Due to Large Vessel Occlusion.

Indobufen versus aspirin in patients with acute ischaemic stroke in China (INSURE): a randomised, double-blind, double-dummy, active control, non-inferiority trial (2023)
Journal Article
Pan, Y., Meng, X., Yuan, B., Johnston, S. C., Li, H., Bath, P. M., …Wang, Y. (2023). Indobufen versus aspirin in patients with acute ischaemic stroke in China (INSURE): a randomised, double-blind, double-dummy, active control, non-inferiority trial. Lancet Neurology, 22(6), 485-493. https://doi.org/10.1016/s1474-4422%2823%2900113-8

Background Aspirin is recommended for secondary stroke prevention in patients with moderate-to-severe ischaemic stroke but can lead to gastrointestinal intolerance and bleeding. Indobufen is used as an alternative antiplatelet agent in some countrie... Read More about Indobufen versus aspirin in patients with acute ischaemic stroke in China (INSURE): a randomised, double-blind, double-dummy, active control, non-inferiority trial.

Comparison Between In‐Hospital and Community‐Onset Stroke Treated With Endovascular Thrombectomy: A Propensity Score–Matched Cohort Study (2023)
Journal Article
Dhillon, P. S., Soo, E., Butt, W., Nguyen, T. N., Barrett, E., Podlasek, A., …England, T. J. (2023). Comparison Between In‐Hospital and Community‐Onset Stroke Treated With Endovascular Thrombectomy: A Propensity Score–Matched Cohort Study. Stroke: Vascular and Interventional Neurology, 3(4), Article e000816. https://doi.org/10.1161/svin.122.000816

Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study (2023)
Journal Article
Andrews, J. A., Craven, M. P., Guo, B., Weyer, J., Lees, S., Zormpas, S. I., …RADAR-CNS Consortium. (2023). Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study. JMIR Neurotechnology, 2, Article e41439. https://doi.org/10.2196/41439

Background: Multiple sclerosis (MS), epilepsy, and depression are chronic central nervous system conditions in which remote measurement technology (RMT) may offer benefits compared with usual assessment. We previously worked with clinicians, patients... Read More about Clinical Perspectives on Using Remote Measurement Technology in Assessing Epilepsy, Multiple Sclerosis, and Depression: Delphi Study.

The impact of tinnitus on adult cochlear implant recipients: A mixed-method approach (2023)
Journal Article
Assouly, K. K., Shabbir, M., van Dijk, B., Hoare, D. J., Akeroyd, M. A., Stokroos, R. J., …Smit, A. L. (2023). The impact of tinnitus on adult cochlear implant recipients: A mixed-method approach. PLoS ONE, 18(4), Article e0284719. https://doi.org/10.1371/journal.pone.0284719

Background Tinnitus is a common problem in patients with a cochlear implant (CI). Between 4% and 25% of CI recipients experience a moderate to severe tinnitus handicap. However, apart from handicap scores, little is known about the real-life impact... Read More about The impact of tinnitus on adult cochlear implant recipients: A mixed-method approach.

Quality of life, wellbeing, recovery, and progress for older forensic mental health patients: a qualitative investigation based on the perspectives of patients and staff (2023)
Journal Article
Walker, K., Yates, J., Dening, T., Völlm, B., Tomlin, J., & Griffiths, C. (2023). Quality of life, wellbeing, recovery, and progress for older forensic mental health patients: a qualitative investigation based on the perspectives of patients and staff. International Journal of Qualitative Studies on Health and Well-being, 18(1), Article 2202978. https://doi.org/10.1080/17482631.2023.2202978

Purpose There is a lack of research informing service requirements for older (aged≥55 years) forensic mental health patients. The aim of this research was to increase knowledge about older forensic mental health patients’ quality of life, wellbeing,... Read More about Quality of life, wellbeing, recovery, and progress for older forensic mental health patients: a qualitative investigation based on the perspectives of patients and staff.

Patient perceptions of cognitive screening in adult audiology services: A qualitative exploration (2023)
Journal Article
Broome, E. E., Tannirandorn, P., Straus, J., Beale, P., Heffernan, E., Dening, T., & Henshaw, H. (2023). Patient perceptions of cognitive screening in adult audiology services: A qualitative exploration. Frontiers in Neurology, 14, Article 1143128. https://doi.org/10.3389/fneur.2023.1143128

Introduction: Both hearing loss and dementia are extremely pervasive, especially amongst older adults. As hearing loss and dementia have common symptoms, misdiagnosis can be common, and failure to address hearing loss for people with dementia could a... Read More about Patient perceptions of cognitive screening in adult audiology services: A qualitative exploration.

A national survey of current provision of waiting list initiatives offered by child and adolescent mental health services in England (2023)
Journal Article
Valentine, A. Z., Sayal, K., Brown, B. J., & Hall, C. L. (2023). A national survey of current provision of waiting list initiatives offered by child and adolescent mental health services in England. British Journal of Child Health, 4(2), 78-83. https://doi.org/10.12968/chhe.2023.4.2.78

Background: Children and young people accessing child and adolescent mental health services (CAMHS) often report delays in receiving an assessment and commencing treatment. In 2018, the James Lind Alliance acknowledged developing CAMHS waiting-list i... Read More about A national survey of current provision of waiting list initiatives offered by child and adolescent mental health services in England.

An Investigation of the Wishes, Needs, Opportunities and Challenges of Accessing Meaningful Activities for People Living with Mild to Moderate Dementia (2023)
Journal Article
Tournier, I., Orton, L., Dening, T., Ahmed, A., Holthoff-Detto, V., & Niedderer, K. (2023). An Investigation of the Wishes, Needs, Opportunities and Challenges of Accessing Meaningful Activities for People Living with Mild to Moderate Dementia. International Journal of Environmental Research and Public Health, 20(7), Article 5358. https://doi.org/10.3390/ijerph20075358

Many people are keen to be actively involved in social life and activities, but even at an early stage, dementia can have a negative impact on social participation and access to leisure activities. As part of the IDoService project, this study has in... Read More about An Investigation of the Wishes, Needs, Opportunities and Challenges of Accessing Meaningful Activities for People Living with Mild to Moderate Dementia.

Effect of proximal blood flow arrest during endovascular thrombectomy (ProFATE): Study protocol for a multicentre randomised controlled trial (2023)
Journal Article
Dhillon, P. S., Butt, W., Podlasek, A., Bhogal, P., McConachie, N., Lenthall, R., …England, T. J. (2023). Effect of proximal blood flow arrest during endovascular thrombectomy (ProFATE): Study protocol for a multicentre randomised controlled trial. European Stroke Journal, 8(2), 581-590. https://doi.org/10.1177/23969873231166194

Background: Observational studies have demonstrated improved outcomes with the adjunctive use of balloon guide catheters (BGC) during endovascular thrombectomy (EVT) for anterior circulation acute ischaemic stroke (AIS). However, the lack of high-lev... Read More about Effect of proximal blood flow arrest during endovascular thrombectomy (ProFATE): Study protocol for a multicentre randomised controlled trial.

Social-emotional well-being and adult hearing loss: clinical recommendations (2023)
Journal Article
Timmer, B. H., Bennett, R. J., Montano, J., Hickson, L., Weinstein, B., Wild, J., …Dyre, L. (2024). Social-emotional well-being and adult hearing loss: clinical recommendations. International Journal of Audiology, 63(6), 381-392. https://doi.org/10.1080/14992027.2023.2190864

Aim: Best-practice in audiological rehabilitation takes a holistic client- and family-centred approach and considers hearing care in the context of personal well-being. Hearing loss not only impairs the ability to hear, but can also compromise the ab... Read More about Social-emotional well-being and adult hearing loss: clinical recommendations.

The leaky pipeline of hearing care: primary to secondary care evidence from the English Longitudinal Study of Ageing (ELSA) (2023)
Journal Article
Tsimpida, D., Rajasingam, S., Panagioti, M., & Henshaw, H. (2024). The leaky pipeline of hearing care: primary to secondary care evidence from the English Longitudinal Study of Ageing (ELSA). International Journal of Audiology, 63(5), 349-357. https://doi.org/10.1080/14992027.2023.2186814

Objective: The proportions of older adults’ transitions through acknowledging their hearing loss to getting access to treatment are unknown. This was examined using data from a nationally representative cohort in England. Design: Patient and healthca... Read More about The leaky pipeline of hearing care: primary to secondary care evidence from the English Longitudinal Study of Ageing (ELSA).

An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis (2023)
Journal Article
Dumitrescu, L., Papathanasiou, A., Coclitu, C., Garjani, A., Evangelou, N., Constantinescu, C. S., …Tanasescu, R. (2023). An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis. Expert Opinion on Pharmacotherapy, 24(4), 495-509. https://doi.org/10.1080/14656566.2023.2178898

Multiple sclerosis (MS) is an immune-mediated disorder of the CNS manifested by recurrent attacks of neurological symptoms (related to focal inflammation) and gradual disability accrual (related to progressive neurodegeneration and neuroinflammation)... Read More about An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis.

Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families (2023)
Journal Article
Neves, R., Perez, B. D. D., Tindall, T., Fernandez, N. S., Panek, R., Wilne, S., …Glazebrook, C. (2023). Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families. Health Expectations, 26(3), 1358-1367. https://doi.org/10.1111/hex.13756

Background/Objectives: Ataxia–telangiectasia (A-T) is a complex inherited disease associated with an increased risk of malignancy. Surveillance guidelines have demonstrated significant health benefits in other cancer predisposition syndromes. However... Read More about Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families.

Incidence and predictors of poor functional outcome despite complete recanalisation following endovascular thrombectomy for acute ischaemic stroke (2023)
Journal Article
Dhillon, P. S., Butt, W., Marei, O., Podlasek, A., McConachie, N., Lenthall, R., …England, T. J. (2023). Incidence and predictors of poor functional outcome despite complete recanalisation following endovascular thrombectomy for acute ischaemic stroke. Journal of Stroke and Cerebrovascular Diseases, 32(5), Article 107083. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107083

Background: Numerous ischaemic stroke patients experience poor functional outcome despite successful recanalisation following endovascular thrombectomy (EVT). We aimed to identify the incidence and predictors of futile complete recanalisation (FCR) i... Read More about Incidence and predictors of poor functional outcome despite complete recanalisation following endovascular thrombectomy for acute ischaemic stroke.

What’s up with everyone?’: The effectiveness of a digital media mental health literacy campaign for young people (2023)
Journal Article
Curran, T., Ito-Jaeger, S., Perez Vallejos, E., & Crawford, P. (2023). What’s up with everyone?’: The effectiveness of a digital media mental health literacy campaign for young people. Journal of Mental Health, 32(3), 612-618. https://doi.org/10.1080/09638237.2023.2182412

Background: In 2021, the Arts and Humanities Research Council commissioned a mass-media mental health campaign called “What’s up With Everyone?” Here, innovative co-created messages were professionally storied and animated by an internationally recog... Read More about What’s up with everyone?’: The effectiveness of a digital media mental health literacy campaign for young people.