An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis

Dumitrescu, Laura; Papathanasiou, Athanasios; Coclitu, Catalina; Garjani, Afagh; Evangelou, Nikos; Constantinescu, Cris S.; Popescu, Bogdan Ovidiu; Tanasescu, Radu

Abstract

Multiple sclerosis (MS) is an immune-mediated disorder of the CNS manifested by recurrent attacks of neurological symptoms (related to focal inflammation) and gradual disability accrual (related to progressive neurodegeneration and neuroinflammation). Sphingosine-1-phosphate-receptor (S1PR) modulators are a class of oral disease-modifying therapies (DMTs) for relapsing MS. The first S1PR modulator developed and approved for MS was fingolimod, followed by siponimod, ozanimod, and ponesimod. All are S1P analogues with different S1PR-subtype selectivity. They restrain the S1P-dependent lymphocyte egress from lymph nodes by binding the lymphocytic S1P-subtype-1-receptor. Depending on their pharmacodynamics and pharmacokinetics, they can also interfere with other biological functions.

Citation

Dumitrescu, L., Papathanasiou, A., Coclitu, C., Garjani, A., Evangelou, N., Constantinescu, C. S., …Tanasescu, R. (2023). An update on the use of sphingosine 1-phosphate receptor modulators for the treatment of relapsing multiple sclerosis. Expert Opinion on Pharmacotherapy, 24(4), 495-509. https://doi.org/10.1080/14656566.2023.2178898

• Journal Article Type: Article
• Acceptance Date: Feb 7, 2023
• Online Publication Date: Mar 22, 2023
• Publication Date: Mar 22, 2023
• Deposit Date: Mar 29, 2023
• Publicly Available Date: Mar 29, 2023
• Journal: Expert Opinion on Pharmacotherapy
• Print ISSN: 1465-6566
• Electronic ISSN: 1744-7666
• Publisher: Informa UK Limited
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 4
• Pages: 495-509
• DOI: https://doi.org/10.1080/14656566.2023.2178898
• Keywords: Pharmacology (medical); Pharmacology; General Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/19002013
• Publisher URL: https://www.tandfonline.com/doi/full/10.1080/14656566.2023.2178898