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Incidence and Predictors of Poor Functional Outcome Despite Complete Recanalisation Following Endovascular Thrombectomy for Acute Ischaemic Stroke

Dhillon, Permesh Singh; Butt, Waleed; Marei, Omar; Podlasek, Anna; McConachie, Norman; Lenthall, Robert; Nair, Sujit; Malik, Luqman; Bhogal, Pervinder; Makalanda, Hegoda Levansri Dilrukshan; Dineen, Robert A.; England, Timothy J.


Permesh Singh Dhillon

Waleed Butt

Omar Marei

Anna Podlasek

Norman McConachie

Robert Lenthall

Sujit Nair

Luqman Malik

Pervinder Bhogal

Hegoda Levansri Dilrukshan Makalanda


Background: Numerous ischaemic stroke patients experience poor functional outcome despite successful recanalisation following endovascular thrombectomy (EVT). We aimed to identify the incidence and predictors of futile complete recanalisation (FCR) in a national stroke registry.

Methods: Patients who achieved complete recanalisation (mTICI 3) following EVT, between October 2015 and March 2020, were included from a United Kingdom national stroke registry. Modified Rankin Scale of 4-6 at discharge was defined as a ‘poor/futile outcome’. Backward stepwise multivariable logistic regression analysis was performed with FCR as the dependent variable, incorporating all baseline characteristics, procedural time metrics and post-procedural events.

Results: We included 2132 of 4383 patients (48.8%) with complete recanalisation post-EVT, of which 948 patients (44.4%) developed FCR. Following multivariable regression analysis adjusted for potential confounders, patients with FCR were associated with multiple baseline patient, imaging and procedural factors: age (p=0.0001), admission NIHSS scores (p=0.0001), pre-stroke disability (p=0.007), onset-to-puncture (p=0.0001) and procedural times (p=0.0001), presence of diabetes (p=0.005), and use of general anaesthesia (p=0.0001). Although not predictive of outcome, post-procedural events including development of any intracranial haemorrhage (ICH) (p=0.0001), symptomatic ICH (sICH) (p=0.0001) and early neurological deterioration (END) (p=0.007) were associated with FCR.

Conclusion: Nearly half of patients in this national registry experienced FCR following EVT. Significant predictors of FCR included increasing age, admission NIHSS scores, pre-stroke disability, onset-to-puncture and procedural times, presence of diabetes, atrial fibrillation, and use of general anaesthesia. Post procedural development of any ICH, sICH, and END were associated with FCR.


Dhillon, P. S., Butt, W., Marei, O., Podlasek, A., McConachie, N., Lenthall, R., …England, T. J. (in press). Incidence and Predictors of Poor Functional Outcome Despite Complete Recanalisation Following Endovascular Thrombectomy for Acute Ischaemic Stroke. Journal of Stroke and Cerebrovascular Diseases,

Journal Article Type Article
Acceptance Date Mar 8, 2023
Deposit Date Mar 13, 2023
Journal Journal of Stroke and Cerebrovascular Diseases
Print ISSN 1052-3057
Publisher Elsevier
Peer Reviewed Peer Reviewed
Keywords Endovascular thrombectomy, symptomatic intracranial hemorrhage, early neurological deterioration, computed tomography, Stroke
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