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Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration (2017)
Journal Article
Negm, O. H., MacKenzie, B., Hamed, M., Ahmad, O., Shone, C. C., Humphreys, D., Acharya, K. R., Loscher, C. E., Marszalowska, I., Lynch, M., Wilcox, M. H., & Monaghan, T. M. (2017). Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration. Clinical and Experimental Immunology, 188(3), 437-443. https://doi.org/10.1111/cei.12946

The prevalence of serum antibodies against Clostridium difficile (CD) toxins A and B in healthy populations have prompted interest in evaluating the therapeutic activity of intravenous immunoglobulin (IVIg) in individuals experiencing severe or recur... Read More about Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration.

New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline (2017)
Journal Article
Corsetti, M., & Whorwell, P. (2017). New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline. Expert Review of Gastroenterology and Hepatology, 11(4), 285-292. https://doi.org/10.1080/17474124.2017.1298442

Introduction: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder which represents a major cost to healthcare services. IBS-D patients represent about one-third of the IBS population and are currently treated with antis... Read More about New therapeutic options for IBS: the role of the first in class mixed µ- opioid receptor agonist and δ-opioid receptor antagonist (mudelta) eluxadoline.

Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma (2017)
Journal Article
Aravinthan, A. D., Bruni, S. G., Doyle, A. C., Thein, H.-H., Goldaracena, N., Issachar, A., Lilly, L. B., Selzner, N., Bhat, M., Sreeharsha, B., Selzner, M., Ghanekar, A., Cattral, M. S., McGilvray, I. D., Greig, P. D., Renner, E. L., Grant, D. R., & Sapisochin, G. (2017). Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma. Annals of Surgical Oncology, 24(7), https://doi.org/10.1245/s10434-017-5789-3

Background: Patients with hepatocellular carcinoma (HCC) beyond the traditional criteria (advanced HCC) are typically offered palliation, which is associated with a 3-year survival rate lower than 30%. This study aimed to describe the outcomes for a... Read More about Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma.

Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study (2017)
Journal Article
West, J., Card, T. R., Aithal, G. P., & Fleming, K. M. (2017). Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study. Alimentary Pharmacology and Therapeutics, 45(7), 983-990. https://doi.org/10.1111/apt.13961

Background: Among patients with cirrhosis, only those determined to be at risk for hepatocellular carcinoma (HCC) should undergo surveillance. However, little is known about how different aetiologies of cirrhosis affect risk for HCC.
Aim: To quantif... Read More about Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study.

Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers (2017)
Journal Article
Deloose, E., Janssen, P., Corsetti, M., Biesiekierski, J., Masuy, I., Rotondo, A., Van Oudenhove, L., Depoortere, I., & Tack, J. (2017). Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers. American Journal of Clinical Nutrition, 105(3), 580-588. https://doi.org/10.3945/ajcn.116.138297

Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion.
Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concen... Read More about Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers.

Adrenergic blockers and the risk for common solid cancers: a case-control study (2017)
Journal Article
Numbere, B., Fleming, K. M., Walker, A., & Card, T. R. (in press). Adrenergic blockers and the risk for common solid cancers: a case-control study. European Journal of Cancer Prevention, 26(1), https://doi.org/10.1097/cej.0000000000000218

Laboratory studies have suggested that adrenergic blockers may inhibit the proliferation and migration of cancer cells, but epidemiological evidence of their effect on cancer incidence has proven inconsistent. We therefore conducted a case-control st... Read More about Adrenergic blockers and the risk for common solid cancers: a case-control study.

Spontaneous extrusion of gallstones after percutaneous drainage (2017)
Journal Article
Hariharan, D., & Lobo, D. N. (2017). Spontaneous extrusion of gallstones after percutaneous drainage. Annals of The Royal College of Surgeons of England, 99(3), Article e1-e2. https://doi.org/10.1308/rcsann.2017.0015

There have been reports of late discharge of gallstones through operative wounds after spillage into the peritoneal cavity during laparoscopic cholecystectomy and after the development of spontaneous cholecystocutaneous fistulae. However, spontaneous... Read More about Spontaneous extrusion of gallstones after percutaneous drainage.