ALOYSIOUS ARAVINTHAN ALOYSIOUS.ARAVINTHAN@NOTTINGHAM.AC.UK
Clinical Associate Professor
Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma
Aravinthan, Aloysious D.; Bruni, Silvio G.; Doyle, Adam C.; Thein, Hla-Hla; Goldaracena, Nicolas; Issachar, Assaf; Lilly, Leslie B.; Selzner, Nazia; Bhat, Mamatha; Sreeharsha, Boraiah; Selzner, Markus; Ghanekar, Anand; Cattral, Mark S.; McGilvray, Ian D.; Greig, Paul D.; Renner, Eberhard L.; Grant, David R.; Sapisochin, Gonzalo
Authors
Silvio G. Bruni
Adam C. Doyle
Hla-Hla Thein
Nicolas Goldaracena
Assaf Issachar
Leslie B. Lilly
Nazia Selzner
Mamatha Bhat
Boraiah Sreeharsha
Markus Selzner
Anand Ghanekar
Mark S. Cattral
Ian D. McGilvray
Paul D. Greig
Eberhard L. Renner
David R. Grant
Gonzalo Sapisochin
Abstract
Background: Patients with hepatocellular carcinoma (HCC) beyond the traditional criteria (advanced HCC) are typically offered palliation, which is associated with a 3-year survival rate lower than 30%. This study aimed to describe the outcomes for a subset of patients with advanced HCC who satisfied the Extended Toronto Criteria (ETC) and were listed for liver transplantation (LT).
Materials & Methods: All patients listed in the Toronto liver transplant program with HCC beyond both the Milan and University of California, San Francisco criteria were included in this study. Data were extracted from the prospectively collected electronic database. All radiological images were reviewed by two independent radiologists. The primary endpoint was patient survival.
Results: Between January 1999 and August 2014, 96 patients with advanced HCC were listed for LT, and 62 (65%) of these patients received bridging therapy while on the waiting list. Bridging therapy led to a significant reduction in tumor progression (p=0.02) and tumor burden (p
Citation
Aravinthan, A. D., Bruni, S. G., Doyle, A. C., Thein, H., Goldaracena, N., Issachar, A., …Sapisochin, G. (2017). Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma. Annals of Surgical Oncology, 24(7), https://doi.org/10.1245/s10434-017-5789-3
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 3, 2017 |
Online Publication Date | Feb 3, 2017 |
Publication Date | Jul 1, 2017 |
Deposit Date | Jul 21, 2017 |
Publicly Available Date | Mar 29, 2024 |
Journal | Annals of Surgical Oncology |
Print ISSN | 1068-9265 |
Electronic ISSN | 1068-9265 |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 24 |
Issue | 7 |
DOI | https://doi.org/10.1245/s10434-017-5789-3 |
Public URL | https://nottingham-repository.worktribe.com/output/869244 |
Publisher URL | https://doi.org/10.1245/s10434-017-5789-3 |
Files
Author's Accepted Manuscript1.pdf
(398 Kb)
PDF
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