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Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma

Aravinthan, Aloysious D.; Bruni, Silvio G.; Doyle, Adam C.; Thein, Hla-Hla; Goldaracena, Nicolas; Issachar, Assaf; Lilly, Leslie B.; Selzner, Nazia; Bhat, Mamatha; Sreeharsha, Boraiah; Selzner, Markus; Ghanekar, Anand; Cattral, Mark S.; McGilvray, Ian D.; Greig, Paul D.; Renner, Eberhard L.; Grant, David R.; Sapisochin, Gonzalo

Authors

Aloysious D. Aravinthan

Silvio G. Bruni

Adam C. Doyle

Hla-Hla Thein

Nicolas Goldaracena

Assaf Issachar

Leslie B. Lilly

Nazia Selzner

Mamatha Bhat

Boraiah Sreeharsha

Markus Selzner

Anand Ghanekar

Mark S. Cattral

Ian D. McGilvray

Paul D. Greig

Eberhard L. Renner

David R. Grant

Gonzalo Sapisochin



Abstract

Background: Patients with hepatocellular carcinoma (HCC) beyond the traditional criteria (advanced HCC) are typically offered palliation, which is associated with a 3-year survival rate lower than 30%. This study aimed to describe the outcomes for a subset of patients with advanced HCC who satisfied the Extended Toronto Criteria (ETC) and were listed for liver transplantation (LT).
Materials & Methods: All patients listed in the Toronto liver transplant program with HCC beyond both the Milan and University of California, San Francisco criteria were included in this study. Data were extracted from the prospectively collected electronic database. All radiological images were reviewed by two independent radiologists. The primary endpoint was patient survival.
Results: Between January 1999 and August 2014, 96 patients with advanced HCC were listed for LT, and 62 (65%) of these patients received bridging therapy while on the waiting list. Bridging therapy led to a significant reduction in tumor progression (p=0.02) and tumor burden (p

Journal Article Type Article
Publication Date Jul 1, 2017
Journal Annals of Surgical Oncology
Print ISSN 1068-9265
Electronic ISSN 1068-9265
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 24
Issue 7
APA6 Citation Aravinthan, A. D., Bruni, S. G., Doyle, A. C., Thein, H., Goldaracena, N., Issachar, A., …Sapisochin, G. (2017). Liver transplantation is a preferable alternative to palliative therapy for selected patients with advanced hepatocellular carcinoma. Annals of Surgical Oncology, 24(7), doi:10.1245/s10434-017-5789-3
DOI https://doi.org/10.1245/s10434-017-5789-3
Publisher URL https://doi.org/10.1245/s10434-017-5789-3
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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