All Outputs (3)

Surgical resection of primary tumour improves aerobic performance in colorectal cancer (2013)
Journal Article
Williams, J. P., Nyasavajjala, S. M., Phillips, B. E., Chakrabarty, M., & Lund, J. N. (2014). Surgical resection of primary tumour improves aerobic performance in colorectal cancer. EJSO - European Journal of Surgical Oncology, 40(2), https://doi.org/10.1016/j.ejso.2013.11.009

Background Colorectal cancer is the third most common cancer in the UK, with patients suffering declines in muscle mass and aerobic function. We hypothesised that tumour removal in non-metastatic colorectal cancer would lead to a restoration of le... Read More about Surgical resection of primary tumour improves aerobic performance in colorectal cancer.

Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions (2013)
Journal Article
Phillips, B. E., Atherton, P. J., Varadhan, K., Wilkinson, D. J., Limb, M. C., Selby, A. L., …Williams, J. P. (2014). Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions. AJP - Endocrinology and Metabolism, 306(2), Article E168-E176. https://doi.org/10.1152/ajpendo.00440.2013

Skeletal muscle anabolism associated with postprandial plasma aminoacidemia and insulinemia is contingent upon amino acids (AA) and insulin crossing the microcirculation-myocyte interface. In this study, we hypothesized that increasing muscle microva... Read More about Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions.

Effects of leucine and its metabolite ?-hydroxy-?-methylbutyrate on human skeletal muscle protein metabolism (2013)
Journal Article
Wilkinson, D., Hossain, T., Hill, D., Phillips, B., Crossland, H., Williams, J., …Atherton, P. (2013). Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. Journal of Physiology, 591(11), https://doi.org/10.1113/jphysiol.2013.253203

Maintenance of skeletal muscle mass is contingent upon the dynamic equilibrium (fasted losses–fed gains) in protein turnover. Of all nutrients, the single amino acid leucine (Leu) possesses the most marked anabolic characteristics in acting as a trig... Read More about Effects of leucine and its metabolite ?-hydroxy-?-methylbutyrate on human skeletal muscle protein metabolism.