All Outputs (556)

Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop (2022)
Journal Article

The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from th... Read More about Remote ischaemic conditioning: defining critical criteria for success—report from the 11th Hatter Cardiovascular Workshop.

A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes (2022)
Journal Article

Purpose: Older people who reside in care homes have varying access and quality of medical care; in the UK, this is provided by general practitioners (GPs). The authors aimed to explore the experiences of trainee GPs in delivering integrated care and... Read More about A qualitative exploratory study of training requirements for general practitioners attending older people resident in care homes.

Breastfeeding in infants diagnosed with phenylketonuria (2022)
Journal Article

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of breastfeeding (exclusive or partial) compared to low-Phe formula feeding in the first six months after birth in infants diag... Read More about Breastfeeding in infants diagnosed with phenylketonuria.

Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability (2022)
Journal Article

New Findings: What is the central question of this study? Can bilateral knee extensor force accuracy be improved following 4 weeks of unilateral force accuracy training and are there any subsequent alterations to central and/or peripheral motor unit... Read More about Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability.

Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR (2022)
Journal Article

Cardiovascular events are the leading cause of death in chronic kidney disease. A recent analysis from the High-Sensitivity Troponin in the Evaluation of Patients With Suspected Acute Coronary Syndrome trial focused on results in those with reduced e... Read More about Room for improvement: diagnosing and managing acute coronary syndromes in persons with reduced eGFR.

Defining improvement in chronic kidney disease: regression and remission (2022)
Journal Article

Purpose of review: International definitions exist for chronic kidney disease (CKD) progression and kidney failure but despite evidence that kidney function may improve, there are no agreed definitions for regression and remission of CKD. In the ligh... Read More about Defining improvement in chronic kidney disease: regression and remission.

Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry (2022)
Journal Article

Introduction The quantitative measurement of circulating gut bacteria-derived metabolites has increased in recent years due to their associations with health and disease. While much of the previous attention has been placed on metabolites consider... Read More about Simple, high-throughput measurement of gut-derived short-chain fatty acids in clinically relevant biofluids using gas chromatography-mass spectrometry.

Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer (2022)
Journal Article

Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT (2022)
Journal Article

Background: In breast cancer management, age-related practice variation is widespread, with older women having lower rates of surgery and chemotherapy than younger women, based on the premise of reduced treatment tolerance and benefit. This may contr... Read More about Improving outcomes for women aged 70 years or above with early breast cancer: research programme including a cluster RCT.

Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review (2022)
Journal Article

Background: The benefit of chemotherapy for older patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer (EBC) is a key area of debate. Gene expression profiling (GEP) may identify p... Read More about Chemotherapy and gene expression profiling in older early luminal breast cancer patients: An International Society of Geriatric Oncology systematic review.

General practitioners' role in improving health care in care homes: a realist review (2022)
Journal Article

Background: Despite recent focus on improving health care in care homes, it is unclear what role general practitioners (GPs) should play. To provide evidence for future practice we set out to explore how GPs have been involved in such improvement... Read More about General practitioners' role in improving health care in care homes: a realist review.

Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies (2022)
Journal Article

Introduction: Guidelines for type 2 diabetes (T2D) recommend individualized HbA1c targets to take into account patient age or frailty. We synthesized evidence from randomized controlled trials and observational studies for intensive glycemic control... Read More about Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies.

Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018 (2022)
Journal Article

Objective: Therapeutic hypothermia (TH) commenced soon after birth for neonatal hypoxic ischaemic encephalopathy (HIE) improves survival and reduces neurodisability. Availability of active TH at the place of birth (Immediate-TH) in the UK is unknown.... Read More about Availability of active therapeutic hypothermia at birth for neonatal hypoxic ischaemic encephalopathy: a UK population study from 2011 to 2018.

Mandatory vaccination against COVID-19 for health and social care workers caring for older people (2022)
Journal Article

The COVID-19 pandemic has particularly adversely affected older people with frailty and functional dependency. Essential regular contact with care staff has been evidenced as an important source of infection for this group. Vaccinating care staff can... Read More about Mandatory vaccination against COVID-19 for health and social care workers caring for older people.

Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists (2022)
Journal Article

The ABCD semaglutide audit was designed to capture the routine clinical outcomes of people commenced on semaglutide in the UK. Previous work showed differential reductions in HbA1c and weight dependent on previous glucagon-like peptide-1 receptor ago... Read More about Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists.

Advance Care Plans in UK care home residents: a service evaluation using a stepped wedge design (2022)
Journal Article

Introduction Advance care planning (ACP) in care homes has high acceptance, increases the proportion of residents dying in place and reduces hospital admissions in research. We investigated whether ACP had similar outcomes when introduced during re... Read More about Advance Care Plans in UK care home residents: a service evaluation using a stepped wedge design.

Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial (2022)
Journal Article

Importance: Hyperintense foci on diffusion-weighted imaging (DWI) that are spatially remote from the acute hematoma occur in 20% of people with acute spontaneous intracerebral hemorrhage (ICH). Tranexamic acid, a hemostatic agent that is under invest... Read More about Effect of Tranexamic Acid Administration on Remote Cerebral Ischemic Lesions in Acute Spontaneous Intracerebral Hemorrhage: A Substudy of a Randomized Clinical Trial.

Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection (2022)
Journal Article

Background: The effectiveness and safety of endovascular thrombectomy (EVT) in the late window (6-24 hours) for acute ischemic stroke (AIS) patients selected without advanced imaging is undetermined. We aimed to assess clinical outcomes and the relat... Read More about Association between time to treatment and clinical outcomes in endovascular thrombectomy beyond 6 hours without advanced imaging selection.

Ageing and exercise-induced motor unit remodelling (2022)
Journal Article

A motor unit (MU) comprises the neuron cell body, its corresponding axon and each of the muscle fibres it innervates. Many studies highlight age-related reductions in the number of MUs, yet the ability of a MU to undergo remodelling and to expand to... Read More about Ageing and exercise-induced motor unit remodelling.

Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans (2022)
Journal Article

Background: The relative role of skeletal muscle mechano-transduction in comparison with systemic hormones, such as testosterone (T), in regulating hypertrophic responses to exercise is contentious. We investigated the mechanistic effects of chemical... Read More about Pharmacological hypogonadism impairs molecular transducers of exercise-induced muscle growth in humans.