Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists

Crabtree, Thomas S. J.; Adamson, Karen; Reid, Hazel; Barnes, Dennis; Sivappriyan, Siva; Bickerton, Alex; Gallen, Ian W.; Field, Benjamin C. T.; Idris, Iskandar; Ryder, Robert E. J.

Abstract

The ABCD semaglutide audit was designed to capture the routine clinical outcomes of people commenced on semaglutide in the UK. Previous work showed differential reductions in HbA1c and weight dependent on previous glucagon-like peptide-1 receptor agonist (GLP-1RA) exposure. The analysis, in this research letter, shows that decreases in HbA1c and weight associated with semaglutide occur irrespective of previous GLP-1RA use. However, HbA1c reductions were less if switched from dulaglutide or liraglutide and weight changes were attenuated if switched from dulaglutide or exenatide, potentially suggesting differing potencies between GLP-1RAs. Dedicated studies with head-to-head comparisons are needed to confirm these findings.

Citation

Crabtree, T. S. J., Adamson, K., Reid, H., Barnes, D., Sivappriyan, S., Bickerton, A., …Ryder, R. E. J. (2022). Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists. Diabetes, Obesity and Metabolism, 24(7), 1398-1401. https://doi.org/10.1111/dom.14701

• Journal Article Type: Article
• Acceptance Date: Mar 22, 2022
• Online Publication Date: Apr 7, 2022
• Publication Date: 2022-07
• Deposit Date: Apr 22, 2022
• Publicly Available Date: Apr 22, 2022
• Journal: Diabetes, Obesity and Metabolism
• Print ISSN: 1462-8902
• Electronic ISSN: 1463-1326
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 7
• Pages: 1398-1401
• DOI: https://doi.org/10.1111/dom.14701
• Keywords: Endocrinology; Endocrinology, Diabetes and Metabolism; Internal Medicine
• Public URL: https://nottingham-repository.worktribe.com/output/7786064
• Publisher URL: https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14701