All Outputs (80)

Concordance between core needle biopsy and surgical excision specimens for Ki-67 in breast cancer–a systematic review of the literature (2021)
Journal Article

Aims: The biomarkers oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) are routinely measured in patients with breast cancer with international consensus on how they should be interpreted. There i... Read More about Concordance between core needle biopsy and surgical excision specimens for Ki-67 in breast cancer–a systematic review of the literature.

Hypoglycaemia in type 2 diabetes treated with pre-mixed insulin (2021)
Journal Article

The burden of hypoglycaemia in type 2 diabetes is increasingly recognised, regardless of treatment regimen.1-3 However, time in hypoglycaemia for individuals with type 2 diabetes who use pre-mixed (biphasic) insulin remains unclear. The aim of our pr... Read More about Hypoglycaemia in type 2 diabetes treated with pre-mixed insulin.

Observational cohort study of changing trends in non-invasive ventilation in very preterm infants and associations with clinical outcomes (2021)
Journal Article

Objective: To determine the change in non-invasive ventilation (NIV) use over time in infants born at

American Society of Clinical Oncology 2021 Podcast: HR+, HER2− Breast Cancer (2021)
Journal Article

Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans (2021)
Journal Article

Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates... Read More about Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.

Short-term, equipment-free high intensity interval training elicits significant improvements in the cardiorespiratory fitness of young adults irrespective of supervision (2021)
Journal Article

Introduction: Serious health implications from having low levels of cardiorespiratory fitness (CRF) and/or being overweight in young adulthood are carried forward into later life. High-intensity interval training (HIIT) is a time-effective, potent s... Read More about Short-term, equipment-free high intensity interval training elicits significant improvements in the cardiorespiratory fitness of young adults irrespective of supervision.

Indicators of response to exercise training: A systematic review and meta-analysis (2021)
Journal Article

Background Means-based analysis of maximal rate of oxygen consumption (VO 2max) has traditionally been used as the exercise response indicator to assess the efficacy of endurance (END), high intensity interval (HIIT) and resistance exercise training... Read More about Indicators of response to exercise training: A systematic review and meta-analysis.

Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial (2021)
Journal Article

Background The Bridging the Age Gap in Breast Cancer research programme sought to improve treatment decision-making for older women with breast cancer by developing and testing, in a cluster randomised trial (n = 1339 patients), two decision support... Read More about Process evaluation of the Bridging the Age Gap in Breast Cancer decision support intervention cluster randomised trial.

Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study (2021)
Journal Article

Health-related quality of life (HRQoL) is severely impaired in persons receiving dialysis. Malnutrition has been associated with some measures of poor HRQoL in cross-sectional analyses in dialysis populations, but no studies have assessed the impact... Read More about Impact of malnutrition on health-related quality of life in persons receiving dialysis: a prospective study.

Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations] (2021)
Journal Article

Although the antimicrobial potential of nitric oxide (NO) is widely published, it is little used clinically. NO is a key signalling molecule modulating vascular, neuronal, inflammatory and immune responses. Endogenous antimicrobial activity is largel... Read More about Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections [version 1; peer review: 1 approved with reservations].

Research into ageing and frailty (2021)
Journal Article

Research into ageing covers opportunities and challenges posed by an older population, and research to understand the ageing processes across the lifespan. The evidence base for Comprehensive Geriatric Assessment (CGA) is well established and efforts... Read More about Research into ageing and frailty.

Communication during the COVID-19 Pandemic: Evaluation-Study on Self-Perceived Competences and Views of Health Care Professionals (2021)
Journal Article

Purpose The aims of this study were to describe communication experiences while wearing a mask during COVID-19 pandemic in 2020, in order to identify possible mask-related barriers to COVID-19-adapted communications and to investigate whether the AB... Read More about Communication during the COVID-19 Pandemic: Evaluation-Study on Self-Perceived Competences and Views of Health Care Professionals.

Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males (2021)
Journal Article

Resistance exercise training (RET) is well-known to counteract negative age-related changes in both muscle and tendon tissue. Traditional RET consists of both concentric (CON) and eccentric (ECC) contractions; nevertheless, isolated ECC contractions... Read More about Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.

Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers (2021)
Journal Article

We explored the views of older (≥65 years) past and potential volunteers in regard to participating in physiology research during the COVID-19 pandemic. Using an online questionnaire and focus groups, we found that past volunteers (n=55) were more li... Read More about Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers.

Biology of primary breast cancer in older women beyond routine biomarkers (2021)
Journal Article

Purpose: There are numerous biomarkers which may have potential predictive and prognostic significance in breast cancer. This is extremely important in older adults, who may opt for less aggressive therapy. This work outlines the literature on biolog... Read More about Biology of primary breast cancer in older women beyond routine biomarkers.

Parents, healthcare professionals and other stakeholders’ experiences of caring for babies born too soon in a low resource setting: A qualitative study of essential newborn care for preterm infants in Kenya (2021)
Journal Article

Objectives: Prematurity is the leading cause of global neonatal and infant mortality. Many babies could survive by the provision of essential newborn care. This qualitative study was conducted in order to understand, from a family and professional pe... Read More about Parents, healthcare professionals and other stakeholders’ experiences of caring for babies born too soon in a low resource setting: A qualitative study of essential newborn care for preterm infants in Kenya.

Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality (2021)
Journal Article

Background: Radiotherapy reduces in-breast recurrence risk in early breast cancer (EBC) in older women. This benefit may be small and should be balanced against treatment effect and holistic patient assessment. This study described treatment patterns... Read More about Observational cohort study in older women with early breast cancer: Use of radiation therapy and impact on health-related quality of life and mortality.

Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential (2021)
Journal Article

Introduction: Assuming myokines underlie some of the health benefits of exercise, we hypothesised that ‘high responder trainer’ (HRT) rats would exhibit distinct myokine profiles to ‘low responder trainers’ (LRT), reflecting distinct health and adapt... Read More about Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential.

HEARTS, minds and souls—it is time for geriatricians to bring more to continence management (2021)
Journal Article

Urinary incontinence (UI), the involuntary loss of urine, is a common health condition that may decrease the quality of life and which increases in incidence and prevalence with age. Recent epidemiologic data suggest an overall prevalence of 38% in w... Read More about HEARTS, minds and souls—it is time for geriatricians to bring more to continence management.

The physiological impact of high‐intensity interval training in octogenarians with comorbidities (2021)
Journal Article

Background Declines in cardiorespiratory fitness (CRF) and fat-free mass (FFM) with age are linked to mortality, morbidity and poor quality of life. High-intensity interval training (HIIT) has been shown to improve CRF and FFM in many groups, but it... Read More about The physiological impact of high‐intensity interval training in octogenarians with comorbidities.