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Effects of leucine and its metabolite ?-hydroxy-?-methylbutyrate on human skeletal muscle protein metabolism (2013)
Journal Article
Wilkinson, D., Hossain, T., Hill, D., Phillips, B., Crossland, H., Williams, J., …Atherton, P. (2013). Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. Journal of Physiology, 591(11), https://doi.org/10.1113/jphysiol.2013.253203

Maintenance of skeletal muscle mass is contingent upon the dynamic equilibrium (fasted losses–fed gains) in protein turnover. Of all nutrients, the single amino acid leucine (Leu) possesses the most marked anabolic characteristics in acting as a trig... Read More about Effects of leucine and its metabolite ?-hydroxy-?-methylbutyrate on human skeletal muscle protein metabolism.

Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study (2013)
Journal Article
John, S. G., Sigrist, M. K., Taal, M. W., & McIntyre, C. W. (2013). Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study. PLoS ONE, 8(5), Article e65372. https://doi.org/10.1371/journal.pone.0065372

Cross-sectional studies in dialysis demonstrate muscle wasting associated with loss of function, increased morbidity and mortality. The relative drivers are poorly understood. There is a paucity of data regarding interval change in muscle in pre-dial... Read More about Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study.

Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms (2013)
Journal Article
Vigneswara, V., Cass, S., Wayne, D., Bolt, E. L., Ray, D. E., & Carter, W. (2013). Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms. PLoS ONE, 8(4), Article e61442. https://doi.org/10.1371/journal.pone.0061442

Abnormal ?-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and ?-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of t... Read More about Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms.

Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections (2013)
Journal Article
Pandolfini, C., Kaguelidou, F., Sequi, M., Jacqz-Aigrain, E., Choonara, I., Turner, M. A., …Bonita, M. (2013). Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections. European Journal of Clinical Pharmacology, 69(4), https://doi.org/10.1007/s00228-012-1415-2

Purpose: To describe the use of ciprofloxacin and fluconazole for the treatment of sepsis in European neonatal intensive care units (NICUs) in order to better orient research aimed at acquiring essential knowledge in this critical area. Methods: The... Read More about Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections.

Invasive lobular carcinoma arising in accessory breast tissue (2013)
Journal Article
Devine, C., Courtney, C., Deb, R., & Agrawal, A. (2013). Invasive lobular carcinoma arising in accessory breast tissue. World Journal of Surgical Oncology, 11(47), Article 47. https://doi.org/10.1186/1477-7819-11-47

Background: Lobular carcinoma in accessory breast tissue is a rare occurrence. We present such a case in a 61-year-old woman. Case presentation: A skin nodule in the axillary skin on excision biopsy revealed invasive lobular carcinoma. Conclus... Read More about Invasive lobular carcinoma arising in accessory breast tissue.

An investigation into the spiritual needs of neuro-oncology patients from a nurse perspective (2013)
Journal Article
Nixon, A. V., Narayanasamy, A., & Penny, V. (2013). An investigation into the spiritual needs of neuro-oncology patients from a nurse perspective. BMC Nursing, 12, Article 2. https://doi.org/10.1186/1472-6955-12-2

Background: Spiritual needs of cancer patients should be assessed and discussed by healthcare professionals. Neurosurgical nurses need to be able to assess and support neuro-oncology patients with their spiritual needs from diagnosis and throughout t... Read More about An investigation into the spiritual needs of neuro-oncology patients from a nurse perspective.

Intestinal ischemia following laparoscopic surgery: a case series (2013)
Journal Article
Al-Khyatt, W., Thomas, J. D., Humes, D. J., & Lobo, D. N. (2013). Intestinal ischemia following laparoscopic surgery: a case series. Journal of Medical Case Reports, 7(25), Article 25. https://doi.org/10.1186/1752-1947-7-25

Introduction: Intestinal ischemia is a rare complication of laparoscopic surgery. Its prognosis depends on a high index of suspicion and effective early treatment. Case presentation: In the present report, we describe three cases where intestinal i... Read More about Intestinal ischemia following laparoscopic surgery: a case series.

Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review (2013)
Journal Article
Al-Khyatt, W., Aggarwal, S., Birchall, J., & Rowlands, T. E. (2013). Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review. World Journal of Emergency Surgery, 8(5), Article 5. https://doi.org/10.1186/1749-7922-8-5

Introduction: An internal hernia is a protrusion of bowel through a normal or abnormal orifice in the peritoneum or mesentery. Although they are considered as a rare cause of intestinal obstruction, paraduodenal hernias are the most common type of... Read More about Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review.

Medication errors in the Middle East countries: a systematic review of the literature (2013)
Journal Article
Alsulami, Z., Conroy, S., & Choonara, I. (2013). Medication errors in the Middle East countries: a systematic review of the literature. European Journal of Clinical Pharmacology, 69(4), https://doi.org/10.1007/s00228-012-1435-y

Background: Medication errors are a significant global concern and can cause serious medical consequences for patients. Little is known about medication errors in Middle Eastern countries. The objectives of this systematic review were to review st... Read More about Medication errors in the Middle East countries: a systematic review of the literature.

Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors (2012)
Journal Article
Alashek, W. A., McIntyre, C. W., & Taal, M. W. (2012). Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors. BMC Infectious Diseases, 12(235), https://doi.org/10.1186/1471-2334-12-265

Background: Patients receiving maintenance haemodialysis (HD) are at higher risk for acquiring Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) infections than the general population. Strict infection control measures are essential to prevent no... Read More about Hepatitis B and C infection in haemodialysis patients in Libya: prevalence, incidence and risk factors.

DNMTs are required for delayed genome instability caused by radiation (2012)
Journal Article
Armstrong, C. A., Jones, G. T., Anderson, R., Iyer, P., Narayanan, D., Sandhu, J., …Tufarelli, C. (2012). DNMTs are required for delayed genome instability caused by radiation. Epigenetics, 7(8), https://doi.org/10.4161/epi.21094

The ability of ionizing radiation to initiate genomic instability has been harnessed in the clinic where the localized delivery of controlled doses of radiation is used to induce cell death in tumor cells. Though very effective as a therapy, tumor re... Read More about DNMTs are required for delayed genome instability caused by radiation.

Pharmacovigilance in children in Camagüey Province, Cuba (2012)
Journal Article
Bárzaga Arencibia, Z., López Leyva, A., Mejías Peña, Y., González Reyes, A., Fernández Manzano, E., & Choonara, I. (2012). Pharmacovigilance in children in Camagüey Province, Cuba. European Journal of Clinical Pharmacology, 68(7), https://doi.org/10.1007/s00228-012-1222-9

Purpose: Our aim was to describe the adverse drug reactions (ADRs) detected following increased education about pharmacovigilance and drug toxicity in children in Camagüey Province, Cuba. Methods: Over a period of 24 months (January 2009 to Dec... Read More about Pharmacovigilance in children in Camagüey Province, Cuba.

Endotoxaemia in haemodialysis: a novel factor in erythropoetin resistance? (2012)
Journal Article
Harrison, L. E., Burton, J. O., Szeto, C., Li, P. K., & McIntyre, C. W. (2012). Endotoxaemia in haemodialysis: a novel factor in erythropoetin resistance?. PLoS ONE, 7(6), Article e40209. https://doi.org/10.1371/journal.pone.0040209

Background/Objectives Translocated endotoxin derived from intestinal bacteria is a driver of systemic inflammation and oxidative stress. Severe endotoxaemia is an underappreciated, but characteristic finding in haemodialysis (HD) patients, and a... Read More about Endotoxaemia in haemodialysis: a novel factor in erythropoetin resistance?.

Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study (2012)
Journal Article
Phillips, B. E., Smith, K., Liptrot, S., Atherton, P. J., Varadhan, K., Rennie, M. J., …Williams, J. P. (2013). Effect of colon cancer and surgical resection on skeletal muscle mitochondrial enzyme activity in colon cancer patients: a pilot study. Journal of Cachexia, Sarcopenia and Muscle, 4(1), 71-77. https://doi.org/10.1007/s13539-012-0073-7

Access to antiepileptic drug therapy in children in Camagüey Province, Cuba (2012)
Journal Article
Bárzaga Arencibia, Z., López Leyvac, A., Mejías Peñad, Y., González Reyes, A. R., Acosta Nápolez, M., Carbonell Perdomo, D., …Choonara, I. (2012). Access to antiepileptic drug therapy in children in Camagüey Province, Cuba. International Journal of Pharmacy Practice, 20(6), https://doi.org/10.1111/j.2042-7174.2012.00215.x

Objective  To describe access to antiepileptic drug therapy and estimate the prevalence of epilepsy in children in Camagüey Province, Cuba. Methods  All the community pharmacies in the province were visited and information collected about the numb... Read More about Access to antiepileptic drug therapy in children in Camagüey Province, Cuba.

Double checking the administration of medicines: what is the evidence? A systematic review (2012)
Journal Article
Alsulami, Z., Conroy, S., & Choonara, I. (2012). Double checking the administration of medicines: what is the evidence? A systematic review. Archives of Disease in Childhood, 97(9), https://doi.org/10.1136/archdischild-2011-301093

Objective To evaluate the evidence for double checking the administration of medicines. Design A systematic search of six electronic databases—Embase, Medline, British Nursing Index and Archive, CINAHL, National electronic library for Medicines (N... Read More about Double checking the administration of medicines: what is the evidence? A systematic review.

Remote automated multi-generational growth and observation of an animal in low Earth orbit (2012)
Journal Article
Oczypok, E. A., Etheridge, T., Freeman, J., Stodieck, L., Johnsen, R., Baillie, D., & Szewczyk, N. J. (2012). Remote automated multi-generational growth and observation of an animal in low Earth orbit. Interface, 9(68), https://doi.org/10.1098/%E2%80%8Brsif.2011.0716

The ultimate survival of humanity is dependent upon colonization of other planetary bodies. Key challenges to such habitation are (patho)physiologic changes induced by known, and unknown, factors associated with long-duration and distance space explo... Read More about Remote automated multi-generational growth and observation of an animal in low Earth orbit.