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All Outputs (7)

Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data (2017)
Journal Article
Sarmanova, A., Hall, M. C., Fernandes, G. S., Bhattacharya, A., Valdes, A. M., Walsh, D. A., …Zhang, W. (in press). Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. Arthritis Research and Therapy, 19(281), https://doi.org/10.1186/s13075-017-1486-7

Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee... Read More about Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data.

Pain mechanisms in rheumatoid arthritis (2017)
Journal Article
McWilliams, D. F., & Walsh, D. A. (2017). Pain mechanisms in rheumatoid arthritis. Clinical and Experimental Rheumatology, 35(S107), Article s94-s101

Understanding of the causes and underlying mechanisms of pain in people with RA is rapidly changing. With the advent of more effective disease modifying drugs, joint inflammation is becoming a more treatable cause of pain, and joint damage can often... Read More about Pain mechanisms in rheumatoid arthritis.

Knee pain and related health in the community study (KPIC): a cohort study protocol (2017)
Journal Article
Fernandes, G. S., Sarmanova, A., Warner, S. C., Harvey, H., Akin-Akinyosoye, K., Richardson, H., …Doherty, M. (in press). Knee pain and related health in the community study (KPIC): a cohort study protocol. BMC Musculoskeletal Disorders, 18(404), https://doi.org/10.1186/s12891-017-1761-4

Background: The incidence, progression and related risk factors for recent-onset knee pain (KP) remain uncertain. This study aims to examine the natural history of KP including incidence and progression and to identify possible phenotypes and their a... Read More about Knee pain and related health in the community study (KPIC): a cohort study protocol.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

New therapeutic targets for osteoarthritis pain (2017)
Journal Article
Walsh, D. A., & Stocks, J. (2017). New therapeutic targets for osteoarthritis pain. Slas Discovery, 22(8), https://doi.org/10.1177/2472555217716912

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe... Read More about New therapeutic targets for osteoarthritis pain.

Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts (2017)
Journal Article
Carpenter, L., Norton, S., Nikiphorou, E., Jayakumar, K., McWilliams, D. F., Rennie, K. L., …Young, A. (2017). Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts. Arthritis Care and Research, 69(12), 1809-1817. https://doi.org/10.1002/acr.23217

Objectives: To assess 5-year progression of erosions and Joint Space Narrowing (JSN), and their associations with RF status in two large, multi-centre early-RA cohorts spanning 25-years. Methods: Radiographic joint damage was recorded using the Sh... Read More about Reductions in radiographic progression in early RA over 25-years: changing contribution from RF in 2 multi-centre UK inception cohorts.