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All Outputs (44)

Sponsorship bias and quality of randomised controlled trials in veterinary medicine (2017)
Journal Article
Wareham, K., Hyde, R., Grindlay, D. J., Brennan, M. L., & Dean, R. S. (in press). Sponsorship bias and quality of randomised controlled trials in veterinary medicine. BMC Veterinary Research, 13(234), https://doi.org/10.1186/s12917-017-1146-9

Background: Randomised controlled trials (RCTs) are considered the gold standard form of evidence for assessing treatment efficacy, but many factors can influence their reliability including methodological quality, reporting quality and funding sourc... Read More about Sponsorship bias and quality of randomised controlled trials in veterinary medicine.

Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room? (2017)
Journal Article
Abhishek, A., & Doherty, M. (2017). Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?. Arthritis Research and Therapy, 19, Article 184. https://doi.org/10.1186/s13075-017-1394-x

The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction... Read More about Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?.

Association of a Family History of Atrial Fibrillation With Incidence and Outcomes of Atrial Fibrillation: A Population-Based Family Cohort Study (2017)
Journal Article
Chang, S. H., Kuo, C. F., Chou, I. J., See, L. C., Yu, K. H., Luo, S. F., …Yeh, Y. H. (2017). Association of a Family History of Atrial Fibrillation With Incidence and Outcomes of Atrial Fibrillation: A Population-Based Family Cohort Study. JAMA Cardiology, 2(8), 863-870. https://doi.org/10.1001/jamacardio.2017.1855

© 2017 American Medical Association. All rights reserved. IMPORTANCE The heritability of atrial fibrillation (AF), the contribution of genetic and environmental factors, and the association of a family history of AF with prognosis are unclear. OBJECT... Read More about Association of a Family History of Atrial Fibrillation With Incidence and Outcomes of Atrial Fibrillation: A Population-Based Family Cohort Study.

Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank (2017)
Journal Article
Runhaar, J., Zhang, W., Rozendaal, R. M., van Middelkoop, M., Bijlsma, H. J., Doherty, M., …Bierma Zeinstra, S. (2017). Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. Annals of the Rheumatic Diseases, 76(11), https://doi.org/10.1136/annrheumdis-2017-211149

Risk of cardiovascular disease in Chinese patients with rheumatoid arthritis: a cross sectional study based on hospital medical records in 10 years (2017)
Journal Article
Zou, K., Xiao, F., Li, H., Zhou, Q., Ban, L., Yang, M., …Zhang, W. (2017). Risk of cardiovascular disease in Chinese patients with rheumatoid arthritis: a cross sectional study based on hospital medical records in 10 years. PLoS ONE, 12(7), Article e0180376. https://doi.org/10.1371/journal.pone.0180376

Objective: Though the risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA) has been established in Western population, little is known about the risk in Chinese people with RA. Our objective was to estimate the risk of CVD in Chinese peo... Read More about Risk of cardiovascular disease in Chinese patients with rheumatoid arthritis: a cross sectional study based on hospital medical records in 10 years.

Putting UK DCTN studies into practice: a nurse and patient perspective of the investigator day for the BLISTER and STOP GAP trials (2017)
Journal Article
Westmoreland, M., Teh-Burden, E., Layfield, C., & Ingrid, T. (2017). Putting UK DCTN studies into practice: a nurse and patient perspective of the investigator day for the BLISTER and STOP GAP trials. Dermatological Nursing, 16(2), 39-41

The BLISTER and STOP GAP studies are two important trials in the field of dermatology and also for the UK Dermatology Clinical Trials Network (UK DCTN) as a collaborative network. They make a significant contribution to our limited evidence base for... Read More about Putting UK DCTN studies into practice: a nurse and patient perspective of the investigator day for the BLISTER and STOP GAP trials.

Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome (2017)
Journal Article
Reckziegel, D., Bailey, H., Cottam, W. J., Tench, C. R., Mahajan, R. P., Walsh, D. A., …Auer, D. P. (in press). Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome. BMJ Open, 7(6), Article e014013. https://doi.org/10.1136/bmjopen-2016-014013

Introduction: Osteoarthritis (OA) pain is a major cause of long-term disability and chronic pain in the adult population. One in five patients does not receive satisfactory pain relief, which reflects the complexity of chronic pain and the current la... Read More about Imaging Pain Relief in Osteoarthritis (IPRO): protocol of a double-blind randomised controlled mechanistic study assessing pain relief and prediction of duloxetine treatment outcome.

A large chronic pericardial effusion in an ultramarathon runner with anti-CCP positive rheumatoid arthritis (2017)
Journal Article
McClelland, T. J., Penfold, R., Kluzek, S., & Nagra, N. S. (2017). A large chronic pericardial effusion in an ultramarathon runner with anti-CCP positive rheumatoid arthritis. BMJ Case Reports, 2017, Article bcr-2017-219350. https://doi.org/10.1136/bcr-2017-219350

Pericardial effusions arise as an extra-articular manifestation of rheumatoid arthritis (RA). Pericardial effusions are often asymptomatic, particularly in the early phase, but patients are at risk of cardiac tamponade as the effusion progresses. We... Read More about A large chronic pericardial effusion in an ultramarathon runner with anti-CCP positive rheumatoid arthritis.

First validation of the gout activity score against gout impact scale in a primary care based gout cohort (2017)
Journal Article
La-Crette, J., Jenkins, W., Fernandes, G. S., Valdes, A. M., Doherty, M., & Abhishek, A. (in press). First validation of the gout activity score against gout impact scale in a primary care based gout cohort. Joint Bone Spine, https://doi.org/10.1016/j.jbspin.2017.05.010

Objectives To validate the gout activity score (GAS) against the gout impact scale in a primary care based gout cohort. Methods This was a single-centre cross-sectional study. People with gout who participated in previous research at Academic Rheuma... Read More about First validation of the gout activity score against gout impact scale in a primary care based gout cohort.

New therapeutic targets for osteoarthritis pain (2017)
Journal Article
Walsh, D. A., & Stocks, J. (2017). New therapeutic targets for osteoarthritis pain. Slas Discovery, 22(8), https://doi.org/10.1177/2472555217716912

Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe... Read More about New therapeutic targets for osteoarthritis pain.

Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks (2017)
Journal Article
Langan, S. M., Stuart, B., Bradshaw, L., Schmitt, J., Williams, H. C., & Thomas, K. S. (2017). Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks. Journal of Allergy and Clinical Immunology, 140(6), 1580-1586. https://doi.org/10.1016/j.jaci.2017.02.043

Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long?term control is important. Well controlled weeks (WCWs) have been used to assess asthma long?term control, but never validated for AD. Objectives: To assess... Read More about Measuring long-term disease control in patients with atopic dermatitis: A validation study of well-controlled weeks.

The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England (2017)
Journal Article
Ban, L., Sprigg, N., Nelson-Piercy, C., Bath, P. M., Ludvigsson, J. F., Stephansson, O., & Tata, L. J. (2017). The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England. Journal of the American Heart Association, 6(4), Article e004601. https://doi.org/10.1161/JAHA.116.004601

Background: Pregnant women may have an increased risk of stroke compared to non-pregnant women of similar age, but the magnitude and the timing of such risk are unclear. We examined the risk of first stroke event in women of childbearing age and comp... Read More about The incidence of first stroke in pregnant and non-pregnant women of childbearing age: a population-based cohort study from England.

The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden (2017)
Journal Article
Ban, L., Abdul Sultan, A., Stephansson, O., Tata, L. J., Sprigg, N., Nelson-Piercy, C., …Ludvigsson, J. F. (2017). The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden. European Stroke Journal, 2(3), 250-256. https://doi.org/10.1177/2396987317706600

Introduction: Research has suggested that delivery is associated with an increased risk of stroke in women; however, there is a lack of contemporary estimates on the incidence of stroke in and after pregnancy compared with the baseline risk in women... Read More about The incidence of first stroke in and around pregnancy: A population-based cohort study from Sweden.

Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK (2017)
Journal Article
Abuabara, K., Magyari, A., Hoffstad, O., Jabbar-Lopez, Z., Smeeth, L., Williams, H., …Langan, S. (2017). Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK. Journal of Investigative Dermatology, 137(8), 1655-1662. https://doi.org/10.1016/j.jid.2017.03.029

Electronic health records hold great promise for clinical and epidemiologic research. Undertaking atopic eczema (AE) research using such data is challenging due to its episodic and heterogeneous nature. We sought to develop and validate a diagnostic... Read More about Development and validation of an algorithm to accurately identify atopic eczema patients in primary care electronic health records from the UK.

A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures (2017)
Journal Article
Khan, T., Grindlay, D. J., Scammell, B. E., Ollivere, B., Manktelow, A., & Pearson, R. G. (2017). A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures. Bone and Joint Journal, 99-B(4_Supple_B), 17-25. https://doi.org/10.1302/0301-620X.99B4.BJJ-2016-1311.R1

Aims The aim of this study was to investigate the outcomes of Vancouver type B2 and B3 fractures by performing a systematic review of the methods of surgical treatment which have been reported. Materials and Methods A systematic search was perform... Read More about A systematic review of Vancouver B2 and B3 periprosthetic femoral fractures.

Risk prediction model for knee pain in the Nottingham Community: a Bayesian modeling approach (2017)
Journal Article
Fernandes, G. S., Bhattacharya, A., McWilliams, D. F., Ingham, S. L., Doherty, M., & Zhang, W. (2017). Risk prediction model for knee pain in the Nottingham Community: a Bayesian modeling approach. Arthritis Research and Therapy, 19, Article 59. https://doi.org/10.1186/s13075-017-1272-6

Background: 25% of the British population over the age of 50 experience knee pain. It can limit physical ability, cause distress and bears significant socioeconomic costs. Knee pain, not knee osteoarthritis (KOA) is the all to common malady. The obje... Read More about Risk prediction model for knee pain in the Nottingham Community: a Bayesian modeling approach.

The placebo effect and its determinants in fibromyalgia: meta-analysis of randomized controlled trials (2017)
Journal Article
Chen, X., Zou, K., Abdullah, N., Whiteside, N., Sarmanova, A., Doherty, M., & Zhang, W. (in press). The placebo effect and its determinants in fibromyalgia: meta-analysis of randomized controlled trials. Clinical Rheumatology, https://doi.org/10.1007/s10067-017-3595-8

The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search... Read More about The placebo effect and its determinants in fibromyalgia: meta-analysis of randomized controlled trials.