Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial

Hewson, David W.; Worcester, Frank; Sprinks, James; Smith, Murray D.; Buchanan, Heather; Breedon, Philip; Hardman, Jonathan G.; Bedforth, Nigel M.

doi:10.1186/s13063-019-3228-4

A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries (2019)
Journal Article
Kettlewell, J., das Nair, R., & Radford, K. (2019). A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries. Clinical Rehabilitation, 33(11), 1705-1712. https://doi.org/10.1177/0269215519865774

Objective: This review aimed to determine the effectiveness of personal smart technologies on outcomes in adults with acquired brain injury. Data sources: A systematic literature search was conducted on 30 May 2019. Twelve electronic databases,... Read More about A systematic review of personal smart technologies used to improve outcomes in adults with acquired brain injuries.

Regaining Confidence after Stroke (RCAS): a feasibility randomised controlled trial (RCT) (2019)
Journal Article
Horne, J. C., Hooban, K. E., Lincoln, N. B., & Logan, P. (2019). Regaining Confidence after Stroke (RCAS): a feasibility randomised controlled trial (RCT). Pilot and Feasibility Studies, 5, 1-12. https://doi.org/10.1186/s40814-019-0480-z

Background: The Regaining Confidence after Stroke Course (RCAS) was designed to facilitate adjustment for people with stroke discharged from rehabilitation. The aim of the trial was to evaluate the feasibility of conducting a randomised trial to comp... Read More about Regaining Confidence after Stroke (RCAS): a feasibility randomised controlled trial (RCT).

Solution Focused brief therapy In post-stroke Aphasia (SOFIA Trial): protocol for a feasibility randomised controlled trial (2019)
Journal Article
Northcott, S., Simpson, A., Thomas, S. A., Hirani, S. P., Flood, C., & Hilari, K. (2019). Solution Focused brief therapy In post-stroke Aphasia (SOFIA Trial): protocol for a feasibility randomised controlled trial. AMRC Open Research, 1, 11. https://doi.org/10.12688/amrcopenres.12873.2

Background: Around a quarter of people post stroke will experience aphasia, a language disability. Having aphasia places someone at risk of becoming depressed and isolated. There is limited evidence for effective interventions to enhance psychologica... Read More about Solution Focused brief therapy In post-stroke Aphasia (SOFIA Trial): protocol for a feasibility randomised controlled trial.

A scoping review of the needs of children and young people with acquired brain injuries and their families (2019)
Journal Article
Keetley, R., Radford, K., & Manning, J. C. (2019). A scoping review of the needs of children and young people with acquired brain injuries and their families. Brain Injury, 33(9), 1117-1128. https://doi.org/10.1080/02699052.2019.1637542

Understanding the needs of children and young people (CYP) with acquired brain injuries (ABI) isessential in delivering pathways of care and providing effective rehabilitation. Aim: To identify relevant literature and key themes relating to the natu... Read More about A scoping review of the needs of children and young people with acquired brain injuries and their families.

Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review (2019)
Journal Article
Booth, V., Harwood, R. H., Hancox, J. E., Hood-Moore, V., Masud, T., & Logan, P. (2019). Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review. BMJ Open, 9(6), Article e024982. https://doi.org/10.1136/bmjopen-2018-024982

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. Objectives This review aimed to identify mechanisms underlying participation in falls prevention interventions, in older adults with cognitive impairment. In par... Read More about Motivation as a mechanism underpinning exercise-based falls prevention programmes for older adults with cognitive impairment: a realist review.

Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial (2019)
Journal Article
Ford, G. A., Bhakta, B. B., Cozens, A., Hartley, S., Holloway, I., Meads, D., …Farrin, A. J. (2019). Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial. Lancet, 18, 530–538

Background Dopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving m... Read More about Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial.

Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders (2019)
Journal Article
Hall, C. L., Brown, S., James, M., Martin, J. L., Brown, N., Selby, K., …Groom, M. J. (2019). Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders. BMC Medical Research Methodology, 19, 1-13. https://doi.org/10.1186/s12874-019-0772-2

Background The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their validity... Read More about Consensus workshops on the development of an ADHD medication management protocol using QbTest: developing a clinical trial protocol with multidisciplinary stakeholders.

Robots in special education: reasons for low uptake (2019)
Journal Article
Galvez Trigo, M. J., Standen, P. J., & Cobb, S. V. G. (2019). Robots in special education: reasons for low uptake. Journal of Enabling Technologies, 13(2), 59-69. https://doi.org/10.1108/jet-12-2018-0070

Purpose: This paper identifies the main reasons for low uptake of robots in Special Education, obtained from an analysis of previous studies that used robots in the area, and from interviewing Special Education teachers about the topic. Design/me... Read More about Robots in special education: reasons for low uptake.

Individualised screening for diabetic retinopathy: the ISDR study—rationale, design and methodology for a randomised controlled trial comparing annual and individualised risk-based variable-interval screening (2019)
Journal Article
Broadbent, D. M., Sampson, C. J., Wang, A., Howard, L., Williams, A. E., Howlin, S. U., …Harding, S. P. (2019). Individualised screening for diabetic retinopathy: the ISDR study—rationale, design and methodology for a randomised controlled trial comparing annual and individualised risk-based variable-interval screening. BMJ Open, 9(6), Article e025788. https://doi.org/10.1136/bmjopen-2018-025788

Introduction: Currently, all people with diabetes (PWD) aged 12 years and over in the UK are invited for screening for diabetic retinopathy (DR) annually. Resources are not increasing despite a 5% increase in the numbers of PWD nationwide each year.... Read More about Individualised screening for diabetic retinopathy: the ISDR study—rationale, design and methodology for a randomised controlled trial comparing annual and individualised risk-based variable-interval screening.

What is the impact of large-scale implementation of stroke Early Supported Discharge?: a mixed methods realist evaluation study protocol (2019)
Journal Article
Fisher, R., Chouliara, N., Byrne, A., Lewis, S., Langhorne, P., Robinson, T., …Walker, M. (2019). What is the impact of large-scale implementation of stroke Early Supported Discharge?: a mixed methods realist evaluation study protocol. Implementation Science, 14, Article 61. https://doi.org/10.1186/s13012-019-0908-0

Background Stroke Early Supported Discharge (ESD) is a service innovation that facilitates discharge from hospital and delivery of specialist rehabilitation in patients’ homes. There is currently widespread implementation of ESD services in many cou... Read More about What is the impact of large-scale implementation of stroke Early Supported Discharge?: a mixed methods realist evaluation study protocol.

Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multi-centred randomised controlled trial, a UK qualitative study (2019)
Journal Article
Smith, B. E., Moffatt, F., Hendrick, P., Bateman, M., Selfe, J., Rathleff, M. S., …Logan, P. (2019). Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multi-centred randomised controlled trial, a UK qualitative study. BMJ Open, 9(6), Article e023805. https://doi.org/10.1136/bmjopen-2018-023805

Objectives: There is an emergent body of evidence supporting exercise therapy and physical activity in the management of musculoskeletal pain. The purpose of this study was to explore potential barriers and facilitators with patients and physiotherap... Read More about Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multi-centred randomised controlled trial, a UK qualitative study.

Factors influencing adherence to home-based strength and balance exercises among older adults with mild cognitive impairment and early dementia: Promoting Activity, Independence and Stability in Early Dementia (PrAISED) (2019)
Journal Article
Hancox, J. E., van der Wardt, V., Pollock, K., Booth, V., Vedhara, K., & Harwood, R. H. (2019). Factors influencing adherence to home-based strength and balance exercises among older adults with mild cognitive impairment and early dementia: Promoting Activity, Independence and Stability in Early Dementia (PrAISED). PLoS ONE, 14(5), Article e0217387. https://doi.org/10.1371/journal.pone.0217387

Background Older adults with dementia are at a high risk of losing abilities and of accidental falls. Promoting Activity, Independence and Stability in Early Dementia (PrAISED) is a 12-month person-centred exercise and activity programme which aims... Read More about Factors influencing adherence to home-based strength and balance exercises among older adults with mild cognitive impairment and early dementia: Promoting Activity, Independence and Stability in Early Dementia (PrAISED).

Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial (2019)
Journal Article
Ford, G. A., Bhakta, B. B., Cozens, A., Hartley, S., Holloway, I., Meads, D., …Farrin, A. J. (2019). Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial. Lancet Neurology, 18(6), 530-538. https://doi.org/10.1016/s1474-4422%2819%2930147-4

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Dopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials... Read More about Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial.

The treatment of hypertension in people with dementia: a multi-centre prospective observational cohort study (2019)
Journal Article
Welsh, T., Gladman, J., & Gordon, A. (2019). The treatment of hypertension in people with dementia: a multi-centre prospective observational cohort study. Journal of the American Medical Directors Association, 20(9), 1111-1115. https://doi.org/10.1016/j.jamda.2019.03.036

Objectives To describe the treatment of hypertension in people with dementia and collate evidence on adverse health events whilst on treatment. Design A multicenter prospective observational cohort study. Setting and participants People with... Read More about The treatment of hypertension in people with dementia: a multi-centre prospective observational cohort study.

Cognitive Management Pathways in Stroke Services (COMPASS): A qualitative investigation of key issues in relation to community stroke teams undertaking cognitive assessments (2019)
Journal Article
Ablewhite, J., Geraghty, J., das Nair, R., Lincoln, N., & Drummond, A. (2019). Cognitive Management Pathways in Stroke Services (COMPASS): A qualitative investigation of key issues in relation to community stroke teams undertaking cognitive assessments. British Journal of Occupational Therapy, 82(7), 404-411. https://doi.org/10.1177/0308022619841320

Introduction Cognitive problems are common after stroke and their identification and management is important for survivors, carers and clinicians. However, the appropriateness of the screening methods and ways in which results inform community cli... Read More about Cognitive Management Pathways in Stroke Services (COMPASS): A qualitative investigation of key issues in relation to community stroke teams undertaking cognitive assessments.

Physical activity engagement strategies in people with dementia – a focus group study (2019)
Journal Article
Harwood, R. H., van der Wardt, V., Hancox, J., Pollock, K., Logan, P., Vedhara, K., & Harwood, R. (2020). Physical activity engagement strategies in people with dementia – a focus group study. Aging and Mental Health, 24(8), 1326-1333. https://doi.org/10.1080/13607863.2019.1590308

Objective: This focus group study aimed to explore how to motivate people with mild cognitive impairment (MCI) or dementia and their carers to engage in exercise and physical activity. Methods: Four focus groups were conducted with six people with... Read More about Physical activity engagement strategies in people with dementia – a focus group study.

A loaded self-managed exercise programme for patellofemoral pain: a mixed methods feasibility study (2019)
Journal Article
Smith, B. E., Hendrick, P., Bateman, M., Moffatt, F., Skovdal Rathleff, M., Selfe, J., …Logan, P. (2019). A loaded self-managed exercise programme for patellofemoral pain: a mixed methods feasibility study. BMC Musculoskeletal Disorders, 20, Article 129. https://doi.org/10.1186/s12891-019-2516-1

Background: A novel loaded self-managed exercise programme that includes pain education and self-management strategies may result in better outcomes for people with patellofemoral pain (PFP). However, establishing program feasibility is an essential... Read More about A loaded self-managed exercise programme for patellofemoral pain: a mixed methods feasibility study.

Developing the React to Falls resources to support care home staff in managing falls (2019)
Journal Article
Robinson, K. R., Jones, K., Balmbra, J., Robertson, K., Horne, J., & Logan, P. A. (2019). Developing the React to Falls resources to support care home staff in managing falls. Journal of Frailty, Sarcopenia and Falls, 4(1), 1-10. https://doi.org/10.22540/JFSF-04-001

Objectives: Care home residents are falling three times more often than elderly frail people living in their own homes and as such, the management of falls is an important area for care home staff to consider. This paper outlines the development of t... Read More about Developing the React to Falls resources to support care home staff in managing falls.

Systematic scoping review of frameworks used to develop rehabilitation interventions for older adults (2019)
Journal Article
Booth, V., Hood-Moore, V., Hancox, J. E., Logan, P., & Robinson, K. R. (2019). Systematic scoping review of frameworks used to develop rehabilitation interventions for older adults. BMJ Open, 9(2), Article e024185. https://doi.org/10.1136/bmjopen-2018-024185

Objectives: Rehabilitation interventions for older adults are complex as they involve a number of interacting components, have multiple outcomes of interest and are influenced by a number of contextual factors. The importance of rigorous intervention... Read More about Systematic scoping review of frameworks used to develop rehabilitation interventions for older adults.

Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial (2019)
Journal Article
Hewson, D. W., Worcester, F., Sprinks, J., Smith, M. D., Buchanan, H., Breedon, P., …Bedforth, N. M. (2019). Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial. Trials, 20(1), Article 129. https://doi.org/10.1186/s13063-019-3228-4

Background The clinical efficacy of effect-site targeted patient-maintained propofol sedation (PMPS) compared to anaesthetist-controlled propofol sedation (ACPS) for patients undergoing awake joint replacement surgery is currently unknown. There is... Read More about Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial.

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