All Outputs (3)

Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13% (2019)
Journal Article
Ruan, C., Wang, C., Tang, Y., Lin, S., Lee, S., Hong, K. S., …De Leon, J. (2019). Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13%. Journal of Clinical Psychopharmacology, 39(6), 644-648. https://doi.org/10.1097/JCP.0000000000001125

Purpose/Background: Clozapine clearance is influenced by sex, smoking status, ethnicity, co-prescription of inducers or inhibitors, obesity and inflammation. In 126 Beijing inpatients, we measured repeated trough steady-state serum concentrations and... Read More about Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13%.

Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease (2019)
Journal Article
D’Souza, T., & Rajkumar, A. P. (2019). Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease. Acta Neuropsychiatrica, 1-13. https://doi.org/10.1017/neu.2019.28

Objective: Cognitive impairment and depression are among the most prevalent and most disabling non-motor symptoms in Parkinson’s disease (PD). The genetic factors that are associated with these symptoms remain uncertain. This systematic review aims... Read More about Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson’s disease.

Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation (2019)
Journal Article
Rajkumar, A. P., Bidkhori, G., Shoaie, S., Clarke, E., Morrin, H., Hye, A., …Aarsland, D. (2020). Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation. American Journal of Geriatric Psychiatry, 28(1), 75-86. https://doi.org/10.1016/j.jagp.2019.06.007

Objectives: Prevalence of Lewy body dementias (LBD) is second only to Alzheimer's disease (AD) among people with neurodegenerative dementia. LBD cause earlier mortality, more intense neuropsychiatric symptoms, more caregivers' burden, and higher cost... Read More about Post-mortem cortical transcriptomics of Lewy body dementia reveal mitochondrial dysfunction and lack of neuroinflammation.