ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma

Nasir, Aishah; Cardall, Alice; Othman, Ramadhan T; Nicolaou, Niovi; Lourdusamy, Anbarasu; Linke, Franziska; Onion, David; Ryzhova, Marina; Cameron, Hanna; Valente, Cara; Korshunov, Andrey; Pfister, Stefan M; Grabowska, Anna M; Kerr, Ian D; Coyle, Beth

doi:10.1093/noajnl/vdab030

All Outputs (63)

The role of ALDH1A1 in contributing to breast tumour aggressiveness: A study conducted in an African population (2021)
Journal Article

Aldehyde dehydrogenase 1 member A1 (ALDH1A1) is one of the most well studied breast cancer stem cells. Its expression has been associated with poor clinicopathological features and clinical outcomes in several studies. This paper studies the expressi... Read More about The role of ALDH1A1 in contributing to breast tumour aggressiveness: A study conducted in an African population.

Clinicopathological and Functional Evaluation Reveal NBS1 as a Predictor of Platinum Resistance in Epithelial Ovarian Cancers (2021)
Journal Article

Platinum resistance seriously impacts on the survival outcomes of patients with ovarian cancers. Platinum-induced DNA damage is processed through DNA repair. NBS1 is a key DNA repair protein. Here, we evaluated the role of NBS1 in ovarian cancers. NB... Read More about Clinicopathological and Functional Evaluation Reveal NBS1 as a Predictor of Platinum Resistance in Epithelial Ovarian Cancers.

ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma (2021)
Journal Article

Background: Therapeutic intervention in metastatic medulloblastoma is dependent upon elucidating the underlying metastatic mechanism. We investigated whether an epithelialmesenchymal transition (EMT)-like pathway could drive medulloblastoma metastasi... Read More about ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.