Proline-rich homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth

Kershaw, Rachael M.; Roberts, Daniel; Wragg, Joseph; Shaaban, Abeer M.; Humphreys, Elizabeth; Halsall, John; Price, Louise; Bicknell, Roy; Gaston, Kevin; Jayaraman, Padma-Sheela

doi:10.1038/oncsis.2017.42

All Outputs (3)

Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism (2017)
Journal Article
Wadey, K., Brown, B., Sala-Newby, G., Jayaraman, P., Gaston, K., & George, S. (2017). Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism. Vascular Pharmacology, 99, 34--44. https://doi.org/10.1016/j.vph.2017.09.004

Neointimal hyperplasia is a product of VSMC replication and consequent accumulation within the blood vessel wall. In this study, we determined whether inhibition of protein kinase CK2 and the resultant stabilisation of proline-rich homeodomain (PRH)... Read More about Protein kinase CK2 inhibition suppresses neointima formation via a proline-rich homeodomain-dependent mechanism.

The enigmatic origin of papillomavirus protein domains (2017)
Journal Article
Puustusmaa, M., Kirsip, H., Gaston, K., & Abroi, A. (2017). The enigmatic origin of papillomavirus protein domains. Viruses, 9(9), https://doi.org/10.3390/v9090240

Almost a century has passed since the discovery of papillomaviruses. A few decades of research have given a wealth of information on the molecular biology of papillomaviruses. Several excellent studies have been performed looking at the long- and sho... Read More about The enigmatic origin of papillomavirus protein domains.

Proline-rich homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth (2017)
Journal Article
Kershaw, R. M., Roberts, D., Wragg, J., Shaaban, A. M., Humphreys, E., Halsall, J., …Jayaraman, P. (2017). Proline-rich homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth. Oncogenesis, 6(6), Article e346. https://doi.org/10.1038/oncsis.2017.42

Breast tumours progress from hyperplasia to ductal carcinoma in situ (DCIS) and invasive breast carcinoma (IBC). PRH/HHEX (Proline Rich Homeodomain/Haematopoietically expressed homeobox) is a transcription factor that displays both tumour suppressor... Read More about Proline-rich homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth.