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Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel (2020)
Journal Article
Appleton, J. P., Richardson, C., Dovlatova, N., May, J., Sprigg, N., Heptinstall, S., & Bath, P. M. (2021). Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel. Stroke and Vascular Neurology, 6(1), 103-108. https://doi.org/10.1136/svn-2020-000346

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients, in part because of treatment resistance. The primary aim was to assess the proportion of patients who are insensitive to clopidogrel. The... Read More about Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel.

Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus (2020)
Journal Article
Basso, L., Boecking, B., Brueggemann, P., Pedersen, N. L., Canlon, B., Cederroth, C. R., & Mazurek, B. (2020). Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus. Frontiers in Neuroscience, 14, Article 706. https://doi.org/10.3389/fnins.2020.00706

Objective: This study aims to identify gender-specific risk factors associated with the presence of bothersome tinnitus (compared with non-bothersome tinnitus), including sociodemographic and lifestyle factors, tinnitus-associated phenomena (hearing... Read More about Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus.

Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews (2020)
Journal Article
Topcu, G., Griffiths, H., Bale, C., Trigg, E., Clarke, S., Potter, K.-J., …das Nair, R. (2020). Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews. Clinical Psychology Review, 82, Article 101923. https://doi.org/10.1016/j.cpr.2020.101923

This meta-review aimed to synthesise evidence on psychosocial adjustment to multiple sclerosis, to identify available treatment models and services for recently diagnosed individuals, and to explore their effectiveness. MEDLINE, CINAHL, EMBASE, PsycI... Read More about Psychosocial adjustment to multiple sclerosis diagnosis: A meta-review of systematic reviews.

The Content and Quality of Information About Hyperacusis Presented Online (2020)
Journal Article
Smith, S. N., Smallwood, E., Sereda, M., Adams, B., & Hoare, D. J. (2020). The Content and Quality of Information About Hyperacusis Presented Online. American Journal of Audiology, 29(3S), 623-630. https://doi.org/10.1044/2020_aja-19-00074

© 2020 American Speech-Language-Hearing Association. Purpose: Hyperacusis is a disorder characterized by reduced sound tolerance leading to ear pain, emotional distress, and reduced quality of life. Many people with hyperacusis turn to the Internet f... Read More about The Content and Quality of Information About Hyperacusis Presented Online.

In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications (2020)
Journal Article
Das, A., Saffaran, S., Chikhani, M., Scott, T. E., Laviola, M., Yehya, N., …Bates, D. G. (2020). In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications. Critical Care Explorations, 2(9), Article e0202. https://doi.org/10.1097/CCE.0000000000000202

Objectives: Patients with COVID-19 Acute Respiratory Distress Syndrome (CARDS) appear to present with at least two distinct phenotypes: severe hypoxemia with relatively well-preserved lung compliance and lung gas volumes (Type 1) and a more conventio... Read More about In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications.

The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants (2020)
Journal Article
Knipper, M., Van Dijk, P., Schulze, H., Mazurek, B., Krauss, P., Scheper, V., …Rüttiger, L. (2020). The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants. Journal of Neuroscience, 40(38), 7190-7202. https://doi.org/10.1523/JNEUROSCI.1314-19.2020

Subjective tinnitus is the conscious perception of sound in the absence of any acoustic source. The literature suggests various tinnitus mechanisms, most of which invoke changes in spontaneous firing rates of central auditory neurons resulting from m... Read More about The Neural Bases of Tinnitus: Lessons from Deafness and Cochlear Implants.

A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study (2020)
Journal Article
McGarry, B. L., Damion, R. A., Chew, I., Knight, M. J., Harston, G. W., Carone, D., …Kauppinen, R. A. (2020). A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study. Journal of Central Nervous System Disease, 12, https://doi.org/10.1177/1179573520943314

Background: T2 relaxation-based magnetic resonance imaging (MRI) signals may provide onset time for acute ischemic strokes with an unknown onset. The ability of visual and quantitative MRI-based methods in a cohort of hyperacute ischemic stroke patie... Read More about A Comparison of T2 Relaxation-Based MRI Stroke Timing Methods in Hyperacute Ischemic Stroke Patients: A Pilot Study.

Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine (2020)
Journal Article
Scutt, P., Woodhouse, L. J., Montgomery, A. A., & Bath, P. M. .. (2020). Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine. BMJ Open, 10(9), Article e038765. https://doi.org/10.1136/bmjopen-2020-038765

Objectives Meta-analysis based on individual patient data (IPD) from randomised trials is superior to using published summary data since it facilitates subgroup and multiple variable analyses. Guidelines and funders expect that researchers share IPD... Read More about Data sharing: experience of accessing individual patient data from completed randomised controlled trials in vascular and cognitive medicine.

Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial (2020)
Journal Article
Kang Law, Z., Dineen, R., England, T. J., Cala, L., Mistri, A. K., Appleton, J. P., …TICH-2 investigators. (2021). Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial. Translational Stroke Research, 12, 275-283. https://doi.org/10.1007/s12975-020-00845-6

Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological deterioration and whether tranexamic acid reduced the risk of neurological deterioration. Data from the Tranexa... Read More about Predictors and outcomes of neurological deterioration in intracerebral hemorrhage: results from the TICH-2 randomised controlled trial.

Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders (2020)
Journal Article
Beeken, L. J., Ting, D. S. J., & Sidney, L. E. (2020). Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders. Stem Cells Translational Medicine, 10(1), 39-49. https://doi.org/10.1002/sctm.20-0118

Ocular surface inflammatory disorders (OSIDs) are a group of highly prevalent, heterogeneous diseases which display a variety of aetiologies and symptoms and are risk factors for serious complications including ocular and cornea impairment. Corneal i... Read More about Potential of mesenchymal stem cells as topical immunomodulatory cell therapies for ocular surface inflammatory disorders.

Auditory dysfunction in type 2 Stickler Syndrome (2020)
Journal Article
Alexander, P., Gomersall, P., Stancel-Lewis, J., Fincham, G. S., Poulson, A., Richards, A., …Snead, M. (2021). Auditory dysfunction in type 2 Stickler Syndrome. European Archives of Oto-Rhino-Laryngology, 278, 2261-2268. https://doi.org/10.1007/s00405-020-06306-y

Purpose To present the extent and site of lesion of auditory dysfunction in a large cohort of individuals with type 2 Stickler Syndrome. Type 2 Stickler syndrome results from a mutation in the gene coding for α-1 type XI pro-collagen, which has been... Read More about Auditory dysfunction in type 2 Stickler Syndrome.

Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys (2020)
Journal Article
Pelekanos, V., Premereur, E., Mitchell, D. J., Chakraborty, S., Mason, S., Lee, A. C., & Mitchell, A. S. (2020). Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys. Journal of Neuroscience, 40(41), 7887-7901. https://doi.org/10.1523/jneurosci.0364-20.2020

The frontal cortex and temporal lobes together regulate complex learning and memory capabilities. Here, we collected resting-state functional and diffusion-weighted MRI data before and after male rhesus macaque monkeys received extensive training to... Read More about Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys.

The impact of video games on ultrasound-guided regional anesthesia skills (2020)
Journal Article
Shafqat, A., Mukarram, S., Bedforth, N. M., Hardman, J. G., & Mccahon, R. A. (2020). The impact of video games on ultrasound-guided regional anesthesia skills. Regional Anesthesia and Pain Medicine, 45(11), 860-865. https://doi.org/10.1136/rapm-2020-101641

Background: There is an association between video game practice and laparoscopic expertise in trainee surgeons. Ultrasound-guided regional anesthesia has many parallels with laparoscopic surgery. The aim of this study was to explore whether video gam... Read More about The impact of video games on ultrasound-guided regional anesthesia skills.

WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry (2020)
Journal Article
Blake, H., Somerset, S., Whittingham, K., Middleton, M., Yildirim, M., & Evans, C. (2020). WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry. International Journal of Environmental Research and Public Health, 17(18), Article 6815. https://doi.org/10.3390/ijerph17186815

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Interprofessional learning (IPL) is essential to prepare healthcare trainees as the future public health workforce. WHIRL (Workplace Health InteRprofessional Learning) was an innovative IPL in... Read More about WHIRL Study: Workplace Health Interprofessional Learning in the Construction Industry.

Antimicrobial peptides in human corneal tissue of patients with fungal keratitis (2020)
Journal Article
Mohammed, I., Mohanty, D., Said, D. G., Barik, M. R., Reddy, M. M., Alsaadi, A., …Mittal, R. (2021). Antimicrobial peptides in human corneal tissue of patients with fungal keratitis. British Journal of Ophthalmology, 105(8), 1172-1177. https://doi.org/10.1136/bjophthalmol-2020-316329

Background Fungal keratitis (FK) is the leading cause of unilateral blindness in the developing world. Antimicrobial peptides (AMPs) have been shown to play an important role on human ocular surface (OS) during bacterial, viral and protozoan infectio... Read More about Antimicrobial peptides in human corneal tissue of patients with fungal keratitis.

Designing and comparing optimized pseudo-continuous Arterial Spin Labeling protocols for measurement of cerebral blood flow (2020)
Journal Article
Woods, J. G., Chappell, M. A., & Okell, T. W. (2020). Designing and comparing optimized pseudo-continuous Arterial Spin Labeling protocols for measurement of cerebral blood flow. NeuroImage, 223, Article 117246. https://doi.org/10.1016/j.neuroimage.2020.117246

Arterial Spin Labeling (ASL) is a non-invasive, non-contrast, perfusion imaging technique which is inherently SNR limited. It is, therefore, important to carefully design scan protocols to ensure accurate measurements. Many pseudo-continuous ASL (PCA... Read More about Designing and comparing optimized pseudo-continuous Arterial Spin Labeling protocols for measurement of cerebral blood flow.

Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea (2020)
Journal Article
Tserga, E., Moreno‐Paublete, R., Sarlus, H., Björn, E., Guimaraes, E., Göritz, C., …Canlon, B. (2020). Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea. FASEB Journal, 34(10), 13978-13992. https://doi.org/10.1096/fj.202001236R

The chemotherapeutic agent cisplatin is renowned for its ototoxic effects. While hair cells in the cochlea are established targets of cisplatin, less is known regarding the afferent synapse, which is an essential component in the faithful temporal tr... Read More about Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea.

The Prevalence and Severity of Misophonia in a UK Undergraduate Medical Student Population and Validation of the Amsterdam Misophonia Scale (2020)
Journal Article
Naylor, J., Caimino, C., Scutt, P., Hoare, D. J., & Baguley, D. M. (2021). The Prevalence and Severity of Misophonia in a UK Undergraduate Medical Student Population and Validation of the Amsterdam Misophonia Scale. Psychiatric Quarterly, 92(2), 609-619. https://doi.org/10.1007/s11126-020-09825-3

Misophonia is a condition of abnormal emotional responses to specific auditory stimuli. There is limited information available on the prevalence of this condition. This study aimed to estimate the prevalence of misophonia in an undergraduate medical... Read More about The Prevalence and Severity of Misophonia in a UK Undergraduate Medical Student Population and Validation of the Amsterdam Misophonia Scale.

Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2) (2020)
Journal Article
Drummond, A., Ablewhite, J., Condon, L., das Nair, R., Jones, A., Jones, F., …Thomas, S. (2020). Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2). British Journal of Occupational Therapy, 83(11), 674-679. https://doi.org/10.1177/0308022620944797

Introduction Post-stroke fatigue is common and is one of the most distressing symptoms after stroke. It has a negative impact on physical, social and psychological functioning; it is also associated with poor outcomes and increased mortality. The... Read More about Developing a Fatigue Programme: Protocol for the Nottingham Fatigue After Stroke (NotFAST2).