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Evidence for biological markers of tinnitus: A systematic review (2021)
Book Chapter
Haider, H. F., Hoare, D. J., Ribeiro, S. F., Ribeiro, D., Caria, H., Trigueiros, N., …Sereda, M. (2021). Evidence for biological markers of tinnitus: A systematic review. In Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment: Towards understanding the complexity of tinnitus (345-398). Elsevier. https://doi.org/10.1016/bs.pbr.2021.01.022

Subjective tinnitus is a phantom sound heard only by the affected person and may be a symptom of various diseases. Tinnitus diagnosis and monitoring is based on subjective audiometric and psychometric methods. This review aimed to synthesize evidence... Read More about Evidence for biological markers of tinnitus: A systematic review.

Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study (2021)
Preprint / Working Paper
Katiri, R., Hall, D. A., Hoare, D. J., Fackrell, K., Horobin, A., Buggy, N., …Core Rehabilitation Outcome Set For Single-Sided Deafness (CROSSSD) Initiative, . Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study

Background: Clinical trials that assess the benefits and harms of an intervention do so by measuring and reporting outcomes. Inconsistent selection and diversity in the choice of outcomes makes it challenging to directly compare interventions. To... Read More about Redesigning a web-based stakeholder consensus meeting about core outcomes for clinical trials: Formative feedback study.

Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases (2021)
Journal Article
Deshmukh, R., Ting, D. S. J., Elsahn, A., Mohammed, I., Said, D. G., & Dua, H. S. (2022). Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases. British Journal of Ophthalmology, 106(8), 1087-1092. https://doi.org/10.1136/bjophthalmol-2020-317907

Purpose: To report the real-world experience of using topical ciclosporin, Ikervis, in the management of ocular surface inflammatory diseases (OSIDs). Methods: This was a retrospective study of patients treated with Ikervis for OSIDs at the Queen’... Read More about Real-world experience of using ciclosporin-A 0.1% (Ikervis) in the management of ocular surface inflammatory diseases.

Ventilation strategies for front of neck airway rescue: an in silico study (2021)
Journal Article
Laviola, M., Niklas, C., Das, A., Bates, D. G., & Hardman, J. G. (2021). Ventilation strategies for front of neck airway rescue: an in silico study. British Journal of Anaesthesia, 126(6), 1226-1236. https://doi.org/10.1016/j.bja.2021.01.030

Background. During induction of general anaesthesia a “can’t intubate, can’t oxygenate” (CICO) situation can arise, leading to severe hypoxaemia. Evidence is scarce to guide ventilation strategies for small-bore front of neck airways that ensure effe... Read More about Ventilation strategies for front of neck airway rescue: an in silico study.

Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study (2021)
Journal Article
Hodkinson, D. J., Bungert, A., Bowtell, R. W., Jackson, S. R., & Jung, J. (2021). Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study. Journal of Neurophysiology, 125(4), 1180-1190. https://doi.org/10.1152/jn.00670.2020

The ability to induce neuroplasticity with non-invasive brain stimulation techniques offers a unique opportunity to examine the human brain systems involved in pain modulation. In experimental and clinical settings, the primary motor cortex (M1) is c... Read More about Operculo-Insular and Anterior Cingulate Plasticity Induced by Transcranial Magnetic Stimulation in the Human Motor Cortex: A Dynamic Casual Modelling Study.

Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial (2021)
Journal Article
Law, Z. K., Desborough, M., Roberts, I., Al‐Shahi Salman, R., England, T. J., Werring, D. J., …Sprigg, N. (2021). Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial. Journal of the American Heart Association, 10(5), Article e019130. https://doi.org/10.1161/jaha.120.019130

Background Antiplatelet therapy increases the risk of hematoma expansion in intracerebral hemorrhage (ICH) while the effect on functional outcome is uncertain. Methods and Results This is an exploratory analysis of the TICH‐2 (Tranexamic Acid in... Read More about Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial.

Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation (2021)
Journal Article
Stolady, D., Laviola, M., Pillai, A., & Hardman, J. G. (2021). Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation. British Journal of Anaesthesia, 126(4), 889-895. https://doi.org/10.1016/j.bja.2020.12.031

Background Studies of pulmonary denitrogenation (pre-oxygenation) in obstetric populations have shown high flow nasal oxygen therapy (HFNO) is inferior to facemask techniques. HFNO achieves median end-tidal oxygen fraction (FE′O2) of 0.87 after 3... Read More about Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation.

Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres (2021)
Journal Article
Wallace, M. N., Sumner, C. J., Berger, J. I., McNaughton, P. A., & Palmer, A. R. (2021). Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres. Neuroscience Letters, 747, Article 135705. https://doi.org/10.1016/j.neulet.2021.135705

Tinnitus has similarities to chronic neuropathic pain where there are changes in the firing rate of different types of afferent neurons. We postulated that one possible cause of tinnitus is a change in the distribution of spontaneous firing rates in... Read More about Salicylate decreases the spontaneous firing rate of guinea pig auditory nerve fibres.

Tinnitus and Tinnitus Disorder: Theoretical and Operational Definitions (An international multidisciplinary proposal) (2021)
Book Chapter
De Ridder, D., Schlee, W., Vanneste, S., Londero, A., Weisz, N., Kleinjung, T., …Langguth, B. (2021). Tinnitus and Tinnitus Disorder: Theoretical and Operational Definitions (An international multidisciplinary proposal). . Elsevier. https://doi.org/10.1016/bs.pbr.2020.12.002

As for hypertension, chronic pain, epilepsy and other disorders with particular symptoms, a commonly accepted and unambiguous definition provides a common ground for researchers and clinicians to study and treat the problem. The WHO's ICD11 definitio... Read More about Tinnitus and Tinnitus Disorder: Theoretical and Operational Definitions (An international multidisciplinary proposal).

Hearing Aids Reduce Daily-Life Fatigue and Increase Social Activity: A Longitudinal Study (2021)
Journal Article
Holman, J. A., Drummond, A., & Naylor, G. (2021). Hearing Aids Reduce Daily-Life Fatigue and Increase Social Activity: A Longitudinal Study. Trends in Hearing, 25, https://doi.org/10.1177/23312165211052786

People with hearing loss experience fatigue, and it is unknown whether this is alleviated by treatment with hearing aids. The objective of this study was to address this issue and to investigate the possible concomitant effect of hearing-aid fitting... Read More about Hearing Aids Reduce Daily-Life Fatigue and Increase Social Activity: A Longitudinal Study.

The prevalence of tinnitus in China: a systematic review of the literature (2021)
Journal Article
Dawei, Z., Xu, Q., Caimino, C., & Baguley, D. M. (2021). The prevalence of tinnitus in China: a systematic review of the literature. Journal of Laryngology and Otology, 135(1), 3-9. https://doi.org/10.1017/S002221512000256X

Purpose: The aim of the present study was to identify reports of the prevalence of tinnitus in China and to present these findings in a review format. Method: We assessed and collated published prevalence estimates of tinnitus and tinnitus severity,... Read More about The prevalence of tinnitus in China: a systematic review of the literature.

Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA) (2021)
Journal Article
Ní Leidhin, C., McMorrow, J., Carey, D., Newman, L., Williamson, W., Fagan, A. J., …Knight, S. P. (2021). Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA). NeuroImage, 229, Article 117741. https://doi.org/10.1016/j.neuroimage.2021.117741

Objective To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged 54 years and older. Backgroun... Read More about Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA).

Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle (2021)
Journal Article
Salvan, P., Wassenaar, T., Wheatley, C., Beale, N., Cottaar, M., Papp, D., …Johansen-Berg, H. (2021). Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle. Journal of Neuroscience, 41(5), 1092-1104. https://doi.org/10.1523/JNEUROSCI.1260-20.2020

© 2021 Salvan et al. The World Health Organization promotes physical exercise and a healthy lifestyle as means to improve youth development. However, relationships between physical lifestyle and human brain development are not fully understood. Here,... Read More about Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle.

The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke (2021)
Journal Article
Alwjwaj, M., Kadir, R. R. A., & Bayraktutan, U. (2021). The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke. Neural Regeneration Research, 16(8), 1483-1489. https://doi.org/10.4103/1673-5374.303012

Ischemic stroke continues to be a leading cause of mortality and morbidity in the world. Despite recent advances in the field of stroke medicine, thrombolysis with recombinant tissue plasminogen activator remains as the only pharmacological therapy f... Read More about The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke.

Pilot Randomised Evaluation of Singing in Dementia (PRESIDE): protocol for a two-arm, parallel group randomised controlled feasibility study with waiting-list control (2021)
Journal Article
Dowson, B., Schneider, J., Guo, B., Bath, P. M., Mcdermott, O., Haywood, L. J., & Orrell, M. (2021). Pilot Randomised Evaluation of Singing in Dementia (PRESIDE): protocol for a two-arm, parallel group randomised controlled feasibility study with waiting-list control. Pilot and Feasibility Studies, 7, Article 15. https://doi.org/10.1186/s40814-020-00759-y

Background As the number of people living with dementia grows, so does the need to provide them with adequate psychosocial support. Many people with dementia live at home with family carers, who also require social and emotional support to cope wi... Read More about Pilot Randomised Evaluation of Singing in Dementia (PRESIDE): protocol for a two-arm, parallel group randomised controlled feasibility study with waiting-list control.

Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance (2021)
Journal Article
Ting, D. S. J., Ho, C. S., Deshmukh, R., Said, D. G., & Dua, H. S. (2021). Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance. Eye, 35, 1084-1101. https://doi.org/10.1038/s41433-020-01339-3

Corneal opacity is the 5th leading cause of blindness and visual impairment globally, affecting ~6 million of the world population. In addition, it is responsible for 1.5–2.0 million new cases of monocular blindness per year, highlighting an ongoing... Read More about Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.

Quantum computing at the frontiers of biological sciences (2021)
Journal Article
Emani, P. S., Warrell, J., Anticevic, A., Bekiranov, S., Gandal, M., McConnell, M. J., …Harrow, A. W. (2021). Quantum computing at the frontiers of biological sciences. Nature Methods, 18, 701-709. https://doi.org/10.1038/s41592-020-01004-3

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovatio... Read More about Quantum computing at the frontiers of biological sciences.

Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being (2021)
Journal Article
Holman, J. A., Hornsby, B. W. Y., Bess, F. H., & Naylor, G. (2021). Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being. International Journal of Audiology, 60(sup2), 47-59. https://doi.org/10.1080/14992027.2020.1853261

Objective Well-being is influenced by the activities we undertake. Hearing loss may reduce well-being directly through increased listening-related fatigue due to cognitive and emotional strain in challenging situations. Hearing loss and hearing devi... Read More about Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being.

Neural Fields with Rebound Currents: Novel Routes to Patterning (2021)
Journal Article
Modhara, S., Lai, Y. M., Thul, R., & Coombes, S. (2021). Neural Fields with Rebound Currents: Novel Routes to Patterning. SIAM Journal on Applied Dynamical Systems, 20(3), 1596-1620. https://doi.org/10.1137/20M1364710

The understanding of how spatio-temporal patterns of neural activity may arise in the cortex of the brain has advanced with the development and analysis of neural field models. To replicate this success for sub-cortical tissues, such as the thalamus,... Read More about Neural Fields with Rebound Currents: Novel Routes to Patterning.