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The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke

Alwjwaj, Mansour; Kadir, Rais Reskiawan A; Bayraktutan, Ulvi


Mansour Alwjwaj

Rais Reskiawan A Kadir


Ischemic stroke continues to be a leading cause of mortality and morbidity in the world. Despite recent advances in the field of stroke medicine, thrombolysis with recombinant tissue plasminogen activator remains as the only pharmacological therapy for stroke patients. However, due to short therapeutic window (4.5 hours of stroke onset) and increased risk of hemorrhage beyond this point, each year globally less than 1% of stroke patients receive this therapy which necessitate the discovery of safe and efficacious therapeutics that can be used beyond the acute phase of stroke. Accumulating evidence indicates that endothelial progenitor cells (EPCs), equipped with an inherent capacity to migrate, proliferate and differentiate, may be one such therapeutics. However, the limited availability of EPCs in peripheral blood and early senescence of few isolated cells in culture conditions adversely affect their application as effective therapeutics. Given that much of the EPC-mediated reparative effects on neurovasculature is realized by a wide range of biologically active substances released by these cells, it is possible that EPC-secretome may serve as an important therapeutic after an ischemic stroke. In light of this assumption, this review paper firstly discusses the main constituents of EPC-secretome that may exert the beneficial effects of EPCs on neurovasculature, and then reviews the currently scant literature that focuses on its therapeutic capacity.


Alwjwaj, M., Kadir, R. R. A., & Bayraktutan, U. (2021). The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke. Neural Regeneration Research, 16(8), 1483-1489.

Journal Article Type Article
Acceptance Date Nov 6, 2020
Online Publication Date Jan 7, 2021
Publication Date Jan 7, 2021
Deposit Date Jan 13, 2021
Publicly Available Date Jan 13, 2021
Journal Neural Regeneration Research
Print ISSN 1673-5374
Publisher Medknow Publications
Peer Reviewed Peer Reviewed
Volume 16
Issue 8
Pages 1483-1489
Keywords antioxidants; cell-based therapy; cell-free therapy; endothelial progenitor cells; inflammatory cytokines; regenerative medicine; secretome; stroke; vasodegeneration; vasorepair
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