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Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging (2013)
Journal Article
Prčkovska, V., Achterberg, H. C., Bastiani, M., Pullens, P., Balmashnova, E., ter Haar Romeny, B. M., …Roebroeck, A. (2013). Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging. International Journal of Biomedical Imaging, 2013, Article 658583. https://doi.org/10.1155/2013/658583

This work investigates the possibilities of applying high-angular-resolution-diffusion-imaging- (HARDI-) based methods in a clinical setting by investigating the performance of non-Gaussian diffusion probability density function (PDF) estimation for... Read More about Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging.

Orthogonal invariant sets of the diffusion tensor and the development of a curvilinear set suitable for low-anisotropy tissues (2013)
Journal Article
Damion, R. A., Radjenovic, A., Ingham, E., Jin, Z., & Ries, M. E. (2013). Orthogonal invariant sets of the diffusion tensor and the development of a curvilinear set suitable for low-anisotropy tissues. PLoS ONE, 8(11), Article e78798. https://doi.org/10.1371/journal.pone.0078798

We develop a curvilinear invariant set of the diffusion tensor which may be applied to Diffusion Tensor Imaging measurements on tissues and porous media. This new set is an alternative to the more common invariants such as fractional anisotropy and t... Read More about Orthogonal invariant sets of the diffusion tensor and the development of a curvilinear set suitable for low-anisotropy tissues.

Tinnitus (2013)
Journal Article
Baguley, D., McFerran, D., & Hall, D. (2013). Tinnitus. Lancet, 382, https://doi.org/10.1016/S0140-6736%2813%2960142-7

Tinnitus is a prevalent experience and, for those who are troubled by it, it can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury and depression, and at presentation the possibility of otologic disease and of anx... Read More about Tinnitus.

Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy (2013)
Journal Article
Harvey, P., Blamire, A. M., Wilson, J. I., Finney, K.-L. N. A., Funk, A. M., Senanayake, P. K., & Parker, D. (2013). Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy. Chemical Science, 4(11), 4251-4258. https://doi.org/10.1039/c3sc51526e

Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance, the resonance is shifted to a region of the 1H NMR spectral win... Read More about Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy.

Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging (2013)
Journal Article
Parker, D., De Luca, E., Botta, M., Harvey, P., Chalmers, K. H., Mishra, A., …Wilson, J. I. (2014). Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging. Journal of Biological Inorganic Chemistry, 19(2), 215-227. https://doi.org/10.1007/s00775-013-1028-y

Medium molecular weight glycol chitosan conjugates have been prepared, linked by an amide bond to paramagnetic Gd(III), Ho(III) and Dy(III) macrocyclic complexes in which a trifluoromethyl reporter group is located 6.5 Å from the paramagnetic centre.... Read More about Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging.

Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study (2013)
Journal Article
Manouchehrinia, A., Tench, C. R., Maxted, J., Bibani, R. H., Britton, J., & Constantinescu, C. S. (2013). Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study. Brain, 136(7), https://doi.org/10.1093/brain/awt139

Tobacco smoking has been linked to an increased risk of multiple sclerosis. However, to date, results from the few studies on the impact of smoking on the progression of disability are conflicting. The aim of this study was to investigate the effects... Read More about Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study.

Paramagnetic Probes for Magnetic Resonance (2013)
Thesis
Harvey, P. Paramagnetic Probes for Magnetic Resonance. (Thesis). Durham University. Retrieved from https://nottingham-repository.worktribe.com/output/2829768

Novel paramagnetic lanthanide complexes have been synthesised for use as probes for magnetic resonance imaging and spectroscopy. Initially, complexes containing a trifluoromethyl group were examined for 19F MRI/S, due to the large chemical shift rang... Read More about Paramagnetic Probes for Magnetic Resonance.

Is Overshoot Caused by an Efferent Reduction in Cochlear Gain? (2013)
Presentation / Conference Contribution
Fletcher, M., de Boer, J., & Krumbholz, K. (2013). Is Overshoot Caused by an Efferent Reduction in Cochlear Gain?. In Basic Aspects of Hearing: Physiology and Perception (65-72). https://doi.org/10.1007/978-1-4614-1590-9_8

Under certain conditions, detection of a masked tone is improved by a preceding sound ("precursor"). This phenomenon is referred to as the "temporal effect" or "overshoot". A prevalent model of overshoot, referred to as the "gain reduction model", po... Read More about Is Overshoot Caused by an Efferent Reduction in Cochlear Gain?.

Management of postkeratoplasty astigmatism by paired arcuate incisions with compression sutures (2013)
Journal Article
Fares, U., Mokashi, A. A., Al-Aqaba, M. A., Otri, A. M., Miri, A., & Dua, H. S. (2013). Management of postkeratoplasty astigmatism by paired arcuate incisions with compression sutures. British Journal of Ophthalmology, 97(4), 438-443. https://doi.org/10.1136/bjophthalmol-2012-302128

Purpose: To analyse the efficacy of paired arcuate incisions and compression sutures technique in the management of post penetrating keratoplasty (PK) astigmatism. Methods: A paired arcuate incision with compression sutures procedure was used to trea... Read More about Management of postkeratoplasty astigmatism by paired arcuate incisions with compression sutures.

Working memory training for adult hearing aid users: study protocol for a double-blind randomized active controlled trial (2013)
Journal Article
Henshaw, H., & Ferguson, M. A. (2013). Working memory training for adult hearing aid users: study protocol for a double-blind randomized active controlled trial. Trials, 14(417), https://doi.org/10.1186/1745-6215-14-417

Background: One in ten people aged between 55 to 74 years have a significant hearing impairment in their better hearing ear (as defined by audiometric hearing thresholds). However, it is becoming increasingly clear that the challenges faced by older... Read More about Working memory training for adult hearing aid users: study protocol for a double-blind randomized active controlled trial.

Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition (2012)
Journal Article
Smith, S. J., Wilson, M., Ward, J. H., Rahman, C. V., Peet, A. C., Macarthur, D. C., …Rahman, R. (2012). Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition. PLoS ONE, 7(12), Article e52335. https://doi.org/10.1371/journal.pone.0052335

INTRODUCTION Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated... Read More about Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition.

Macroscopic and microscopic study of 1-Ethyl-3-methyl-imidazolium acetate-water mixtures (2012)
Journal Article
Hall, C. A., Le, K. A., Rudaz, C., Radhi, A., Lovell, C. S., Damion, R. A., …Ries, M. E. (2012). Macroscopic and microscopic study of 1-Ethyl-3-methyl-imidazolium acetate-water mixtures. Journal of Physical Chemistry B, 116(42), 12810-12818. https://doi.org/10.1021/jp306829c

Mixtures of 1-ethyl-3-methyl-imidazolium acetate ([C2mim][OAc]) and water across the entire composition range, from pure [C2mim][OAc] to pure water, have been investigated using density, viscosity, and NMR spectroscopy, relaxometry, and diffusion mea... Read More about Macroscopic and microscopic study of 1-Ethyl-3-methyl-imidazolium acetate-water mixtures.

Computer skills and internet use in adults aged 50-74 years: influence of hearing difficulties (2012)
Journal Article
Henshaw, H., Clark, D. P., Kang, S., & Ferguson, M. A. (2012). Computer skills and internet use in adults aged 50-74 years: influence of hearing difficulties. Journal of Medical Internet Research, 14(4), Article e113. https://doi.org/10.2196/jmir.2036

BACKGROUND The use of personal computers (PCs) and the Internet to provide health care information and interventions has increased substantially over the past decade. Yet the effectiveness of such an approach is highly dependent upon whether the t... Read More about Computer skills and internet use in adults aged 50-74 years: influence of hearing difficulties.

Effects of frequency discrimination training on tinnitus: results from two randomised controlled trials (2012)
Journal Article
Hoare, D. J., Kowalkowski, V. L., & Hall, D. A. (2012). Effects of frequency discrimination training on tinnitus: results from two randomised controlled trials. Journal of the Association for Research in Otolaryngology, 13(4), https://doi.org/10.1007/s10162-012-0323-6

That auditory perceptual training may alleviate tinnitus draws on two observations: (1) tinnitus probably arises from altered activity within the central auditory system following hearing loss and (2) sound-based training can change central auditory... Read More about Effects of frequency discrimination training on tinnitus: results from two randomised controlled trials.

Human cortical connectome reconstruction from diffusion weighted MRI: The effect of tractography algorithm (2012)
Journal Article
Bastiani, M., Shah, N. J., Goebel, R., & Roebroeck, A. (2012). Human cortical connectome reconstruction from diffusion weighted MRI: The effect of tractography algorithm. NeuroImage, 62(3), 1732-1749. https://doi.org/10.1016/j.neuroimage.2012.06.002

Reconstructing the macroscopic human cortical connectome by Diffusion Weighted Imaging (DWI) is a challenging research topic that has recently gained a lot of attention. In the present work, we investigate the effects of intra-voxel fiber direction m... Read More about Human cortical connectome reconstruction from diffusion weighted MRI: The effect of tractography algorithm.

Paramagnetic 19F Chemical Shift Probes that Respond Selectively to Calcium or Citrate Levels and Signal Ester Hydrolysis (2012)
Journal Article
Harvey, P., Chalmers, K. H., De Luca, E., Mishra, A., & Parker, D. (2012). Paramagnetic 19F Chemical Shift Probes that Respond Selectively to Calcium or Citrate Levels and Signal Ester Hydrolysis. Chemistry - A European Journal, 18(28), 8748-8757. https://doi.org/10.1002/chem.201200737

Paramagnetic magnetic resonance chemical shift probes containing a proximal CF3 group have been characterised. Different systems have been created that report reversible changes in calcium ion concentrations in the millimolar regime, signal the prese... Read More about Paramagnetic 19F Chemical Shift Probes that Respond Selectively to Calcium or Citrate Levels and Signal Ester Hydrolysis.