Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners

Smith, L.; Elwick, H.; Mhizha-Murira, J.R.; Topcu, G.; Bale, C.; Evangelou, N.; Timmons, S.; Leighton, P.; Das Nair, Roshan

doi:10.1016/j.msard.2020.102563

The perceptual limitations of troubleshooting hearing-aids based on patients’ descriptions (2020)
Journal Article
Caswell-Midwinter, B., & Whitmer, W. M. (2021). The perceptual limitations of troubleshooting hearing-aids based on patients’ descriptions. International Journal of Audiology, 60(6), 427-437. https://doi.org/10.1080/14992027.2020.1839679

Objectives: Hearing-aid frequency-gain responses are routinely adjusted by clinicians to patient preferences and descriptions. This study measured the minimum gain adjustments required to elicit preferences, and the assignment of descriptors to gain... Read More about The perceptual limitations of troubleshooting hearing-aids based on patients’ descriptions.

Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial (2020)
Journal Article
Desborough, M. J., Al-Shahi Salman, R., Stanworth, S. J., Havard, D., Brennan, P. M., Dineen, R. A., …DASH trial investigators. (2020). Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial. BMJ Open, 10(11), Article e037555. https://doi.org/10.1136/bmjopen-2020-037555

Introduction Intracerebral haemorrhage (ICH) can be devastating and is a common cause of death and disability worldwide. Pre-ICH antiplatelet drug use is associated with a 27% relative increase in 1 month case fatality compared with patients not usin... Read More about Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double blind randomised controlled feasibility trial.

Morbidity and complications of diabetes mellitus in children and adolescents in Ghana: study design and rationale (2020)
Preprint / Working Paper
Essuman, V. A., Tagoe, N. N., Akpalu, J., Essuman, A., Sackey, A., Hayfron-Benjamin, C., …Amoaku, W. Morbidity and complications of diabetes mellitus in children and adolescents in Ghana: study design and rationale

Background: Diabetes is associated with premature morbidity and mortality from its many complications. There is limited data on the chronic complications of diabetes in children and adolescents in sub-Saharan Africa. Objective: The study aims t... Read More about Morbidity and complications of diabetes mellitus in children and adolescents in Ghana: study design and rationale.

Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial (2020)
Journal Article
Beishon, L., Woodhouse, L. J., Bereczki, D., Christensen, H. K., Collins, R., Gommans, J., …Bath, P. M. (2021). Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial. Stroke and Vascular Neurology, 6(2), 180-186. https://doi.org/10.1136/svn-2020-000498

Introduction Nitrate-induced headache is common and may signify responsive cerebral vasculature. We assessed the relationship between nitrate headache and outcome in patients with acute stroke. Materials and methods Patients were those randomised to... Read More about Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial.

The feasibility of an m-health educational programme (m2Hear) to improve outcomes in first-time hearing aid users (2020)
Journal Article
Ferguson, M. A., Maidment, D. W., Gomez, R., Coulson, N., & Wharrad, H. (2020). The feasibility of an m-health educational programme (m2Hear) to improve outcomes in first-time hearing aid users. International Journal of Audiology, 60(Supplement 1), S30-S41. https://doi.org/10.1080/14992027.2020.1825839

© 2020 Crown Copyright. Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of British Society of Audiology, International Society of Audiology, and Nordic Audiological Society. Objective: To (i) assess the delivery, access... Read More about The feasibility of an m-health educational programme (m2Hear) to improve outcomes in first-time hearing aid users.

Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study (2020)
Journal Article
Bath, P. M., Woodhouse, L. J., Suntrup-Krueger, S., Likar, R., Koestenberger, M., Warusevitane, A., …Dziewas, R. (2020). Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study. eClinicalMedicine, 28, Article 100608. https://doi.org/10.1016/j.eclinm.2020.100608

Background: Neurogenic dysphagia is common and has no definitive treatment. We assessed whether pharyngeal electrical stimulation (PES) is associated with reduced dysphagia. Methods: The PHAryngeal electrical stimulation for treatment of neurogenic D... Read More about Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study.

‘That’s just how I am’: a qualitative interview study to identify factors influencing engagement with a digital intervention for tinnitus self-management (2020)
Journal Article
Greenwell, K., Sereda, M., Coulson, N. S., Geraghty, A. W., Bradbury, K., & Hoare, D. J. (2020). ‘That’s just how I am’: a qualitative interview study to identify factors influencing engagement with a digital intervention for tinnitus self-management. British Journal of Health Psychology, https://doi.org/10.1111/bjhp.12486

© 2020 The Authors. British Journal of Health Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society Objectives: To explore users’ reactions to and expectations of the Tinnitus E-Programme 2.0, a digital cognitive... Read More about ‘That’s just how I am’: a qualitative interview study to identify factors influencing engagement with a digital intervention for tinnitus self-management.

Altered hippocampal functional connectivity patterns in patients with cognitive impairments following ischaemic stroke: a resting-state fMRI study (2020)
Preprint / Working Paper
Jung, J., Laverick, R., Nader, K., Wilson, M., Auer, D. P., Rotshtein, P., & Hosseini, A. A. Altered hippocampal functional connectivity patterns in patients with cognitive impairments following ischaemic stroke: a resting-state fMRI study

Background Ischemic stroke with cognitive impairment is a considerable risk factor for developing dementia. Identifying imaging markers of cognitive impairment following ischemic stroke will help to develop prevention strategies against post-stroke d... Read More about Altered hippocampal functional connectivity patterns in patients with cognitive impairments following ischaemic stroke: a resting-state fMRI study.

Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis (2020)
Journal Article
Appleton, J. P., Woodhouse, L. J., Sprigg, N., Wardlaw, J. M., & Bath, P. M. (2020). Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis. Frontiers in Neurology, 11, Article 584038. https://doi.org/10.3389/fneur.2020.584038

Background: Thrombolysis, with or without thrombectomy, for acute ischaemic stroke is associated with an increased risk of intracranial bleeding. We assessed whether treatment with glyceryl trinitrate (GTN), a nitric oxide donor, may influence the as... Read More about Intracranial Bleeding After Reperfusion Therapy in Acute Ischaemic Stroke Patients Randomized to Glyceryl Trinitrate vs. Control: An Individual Patient Data Meta-Analysis.

Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals (2020)
Journal Article
Luney, M., Lindsay, W., McKeever, T. M., & Moppett, I. K. (2020). Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals. BMJ Open, 10(10), Article e037904. https://doi.org/10.1136/bmjopen-2020-037904

Introduction: An increasing number of people who have a history of acute coronary syndrome or cerebrovascular accident (termed cardiovascular events) are being considered for surgery. Up-to-date evidence of the impact of these prior events is needed... Read More about Cerebrovascular accident and acute coronary syndrome and perioperative outcomes (CAPO) study protocol: a 10-year database linkage between Hospital Episode Statistics Admitted Patient Care, Myocardial Infarction National Audit Project and Office for National Statistics registries for time-dependent risk analysis of perioperative outcomes in English NHS hospitals.

Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis (2020)
Journal Article
Meng, D., Welton, T., Elsarraj, A., Morgan, P. S., das Nair, R., Constantinescu, C. S., …Dineen, R. A. (2020). Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis. Human Brain Mapping, 42(2), 495-509. https://doi.org/10.1002/hbm.25239

Three decades ago a series of parallel circuits were described involving the frontal cortex and deep grey matter structures, with putative roles in control of motor and oculomotor function, cognition, behaviour and emotion. The circuit comprising the... Read More about Dorsolateral prefrontal circuit effective connectivity mediates the relationship between white matter structure and PASAT‐3 performance in multiple sclerosis.

Exploring the Factor Structure of the Glasgow Children’s Benefit Inventory: New Recommendations for Reporting Results (2020)
Journal Article
Kubba, H., & Whitmer, W. M. (2021). Exploring the Factor Structure of the Glasgow Children’s Benefit Inventory: New Recommendations for Reporting Results. Annals of Otology, Rhinology & Laryngology, 130(6), 614-622. https://doi.org/10.1177/0003489420965634

Objective Patient-reported outcomes can be useful for reporting benefit from non-life-saving interventions, but often they report a single overall score, which means that much information on the specific areas of benefit is lost. Our aim was to per... Read More about Exploring the Factor Structure of the Glasgow Children’s Benefit Inventory: New Recommendations for Reporting Results.

Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates (2020)
Journal Article
Burgess, L., Wilson, H., Jones, A. R., Harvey, P., Natrajan, L., & Hay, S. (2020). Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates. Chemistry - A European Journal, 26(65), 14817-14822. https://doi.org/10.1002/chem.202001974

Upconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive alternative to organic fluorophores for use as luminescent probes. Here, UCPs were capped wit... Read More about Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates.

Conversation in small groups: Speaking and listening strategies depend on the complexities of the environment and group (2020)
Journal Article
Hadley, L. V., Whitmer, W. M., Brimijoin, W. O., & Naylor, G. (2021). Conversation in small groups: Speaking and listening strategies depend on the complexities of the environment and group. Psychonomic Bulletin and Review, 28(2), 632-640. https://doi.org/10.3758/s13423-020-01821-9

Many conversations in our day-to-day lives are held in noisy environments, impeding comprehension, and in groups, taxing auditory attention-switching processes. These situations are particularly challenging for older adults in cognitive and sensory d... Read More about Conversation in small groups: Speaking and listening strategies depend on the complexities of the environment and group.

Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol (2020)
Journal Article
Wardlaw, J. M., Doubal, F., Brown, R., Backhouse, E., Woodhouse, L., Bath, P., …R4VaD Investigators. (2021). Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol. European Stroke Journal, 6(1), 89-101. https://doi.org/10.1177/2396987320953312

Background: Stroke commonly affects cognition and, by definition, much vascular dementia follows stroke. However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding of prevalence, trajec... Read More about Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol.

Uncertainty modelling in deep learning for safer neuroimage enhancement: Demonstration in diffusion MRI (2020)
Journal Article
Tanno, R., Worrall, D. E., Kaden, E., Ghosh, A., Grussu, F., Bizzi, A., …Alexander, D. C. (2021). Uncertainty modelling in deep learning for safer neuroimage enhancement: Demonstration in diffusion MRI. NeuroImage, 225, Article 117366. https://doi.org/10.1016/j.neuroimage.2020.117366

Deep learning (DL) has shown great potential in medical image enhancement problems, such as super-resolution or image synthesis. However, to date, most existing approaches are based on deterministic models, neglecting the presence of different source... Read More about Uncertainty modelling in deep learning for safer neuroimage enhancement: Demonstration in diffusion MRI.

Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study (2020)
Journal Article
Conlon, B., Langguth, B., Hamilton, C., Hughes, S., Meade, E., Connor, C. O., …Lim, H. H. (2020). Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study. Science Translational Medicine, 12(564), Article eabb2830. https://doi.org/10.1126/scitranslmed.abb2830

Tinnitus is a phantom auditory perception coded in the brain that can be bothersome or debilitating, affecting 10 to 15% of the population. Currently, there is no clinically recommended drug or device treatment for this major health condition. Animal... Read More about Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study.

Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial (2020)
Journal Article
Minhas, J. S., Wang, X., Lindley, R. I., Delcourt, C., Song, L., Woodward, M., …Robinson, T. G. (2021). Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial. Journal of Hypertension, 39(2), 280-285. https://doi.org/10.1097/hjh.0000000000002640

Objective: Limited data exist on the optimum level of systolic blood pressure (BP) in thrombolyzed patients with acute ischemic stroke (AIS). We aimed to determine the effects of intensive BP lowering, specifically in patients with severe AIS who par... Read More about Comparative effects of intensive-versus standard-BP lowering treatment in patients with severe ischemic stroke in the ENCHANTED trial.

Clinical management of cerebral small vessel disease: a call for a holistic approach (2020)
Journal Article
Clancy, U., Appleton, J. P., Arteaga, C., Doubal, F. N., Bath, P. M., & Wardlaw, J. M. (2021). Clinical management of cerebral small vessel disease: a call for a holistic approach. Chinese Medical Journal, 134(2), 127-142. https://doi.org/10.1097/cm9.0000000000001177

Cerebral small vessel disease (SVD) is a common global brain disease that causes cognitive impairment, ischemic or hemorrhagic stroke, problems with mobility, and neuropsychiatric symptoms. The brain damage, seen as focal white and deep grey matter l... Read More about Clinical management of cerebral small vessel disease: a call for a holistic approach.

Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners (2020)
Journal Article
Smith, L., Elwick, H., Mhizha-Murira, J., Topcu, G., Bale, C., Evangelou, N., …Das Nair, R. (2021). Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners. Multiple Sclerosis and Related Disorders, 49, Article 102563. https://doi.org/10.1016/j.msard.2020.102563

Background: Cognitive problems are a common and debilitating symptom of multiple sclerosis (MS). Screening and treatment for cognitive problems are recommended, however these are not routinely delivered in UK clinics. We collected and synthesised... Read More about Developing a clinical pathway to identify and manage cognitive problems in Multiple Sclerosis: Qualitative findings from patients, family members, charity volunteers, clinicians and healthcare commissioners.

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