Dr JEYOUNG JUNG Jeyoung.Jung@nottingham.ac.uk
Assistant Professor
Dr JEYOUNG JUNG Jeyoung.Jung@nottingham.ac.uk
Assistant Professor
Rosanna Laverick
Kurdow Nader
Martin Wilson
DOROTHEE AUER dorothee.auer@nottingham.ac.uk
Professor of Neuroimaging
Pia Rotshtein
Akram A. Hosseini
Background Ischemic stroke with cognitive impairment is a considerable risk factor for developing dementia. Identifying imaging markers of cognitive impairment following ischemic stroke will help to develop prevention strategies against post-stroke dementia.
Methods Here, we investigated the hippocampal functional connectivity (FC) pattern following ischemic stroke, using resting-state fMRI (rs-fMRI). Thirty-three cognitively impaired patients after ischemic stroke and sixteen age-matched controls with no known history of neurological disorder, were recruited for the study. Importantly, no patient had a direct ischaemic insult to hippocampus on examination of brain imaging. Seven subfields of hippocampus were used as a seed region for FC analyses.
Results Across all hippocampal subfields, FC with the inferior parietal lobe in patients was reduced as compared with healthy controls. This decreased FC included both supramarginal gyrus and angular gyrus. The FC of hippocampal subfields with cerebellum was increased. Importantly, the degree of the altered FC between hippocampal subfields and IPL was associated with their impaired memory function.
Conclusion Our results demonstrated that decreased hippocampal-IPL connectivity was associated with cognitive impairment in patients with ischemic stroke. These findings provide novel insights into the role of hippocampus in cognitive impairment following ischemic stroke.
Deposit Date | Jul 12, 2021 |
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Publicly Available Date | Jul 13, 2021 |
Public URL | https://nottingham-repository.worktribe.com/output/5008981 |
Publisher URL | https://www.medrxiv.org/content/10.1101/2020.10.26.20219782v1 |
Altered hippocampal functional connectivity patterns
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