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Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials (2007)
Journal Article
Bath, P. M., & Optimising Analysis of Stroke Trials Collaboration, O. (2007). Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials. Stroke, 38(6), https://doi.org/10.1161/STROKEAHA.106.474080

Background and Purpose—Most large acute stroke trials have been neutral. Functional outcome is usually analyzed usinga yes or no answer, eg, death or dependency versus independence. We assessed which statistical approaches are mostefficient in analyz... Read More about Can we improve the statistical analysis of stroke trials? Statistical re-analysis of functional outcomes in stroke trials.

Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2007)
Journal Article
Sprigg, N., Gray, L. J., Bath, P. M., Lindenstrom, E., Boysen, G., De Deyn, P. P., Friis, P., Leys, D., Marttila, R., Olsson, J.-E., O'Neill, D., & Ringelstein, B. (2007). Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST). Journal of the Neurological Sciences, 254(1-2),

Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute Ischaemic Stroke Trial’ (TAIST) to assess the relation... Read More about Stroke severity, early recovery and outcome are each related with clinical classification of stroke: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333) (2007)
Journal Article
Sprigg, N., Willmot, M., Gray, L. J., Sunderland, A., Pomeroy, V., Walker, M., & Bath, P. M. (2007). Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333). Journal of Human Hypertension, 21(8),

Amphetamine enhances recovery after experimental ischaemia and has shown promise in small clinical trials when combined with motor or sensory stimulation. Amphetamine, a sympathomimetic, might have haemodynamic effects in stroke patients, although li... Read More about Amphetamine increases blood pressure and heart rate but has no effect on motor recovery or cerebral haemodynamics in ischaemic stroke: a randomized controlled trial (ISRCTN 36285333).

Unruptured arteriovenous malformations of the brain (2007)
Journal Article
Al-Shahi Salman, R., Mast, H., & Stapf, C. (2007). Unruptured arteriovenous malformations of the brain. Advances in Clinical Neuroscience and Rehabilitation, 6(6),

Unruptured, asymptomatic arteriovenous malformations (AVMs) lurk in the brains of approximately one person in every thousand; their prevalence, based on four studies of magnetic resonance imaging (MRI) of 7,359 people without brain disorders, 1-4 was... Read More about Unruptured arteriovenous malformations of the brain.

Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092) (2006)
Journal Article
Sprigg, N., Bath, P. M., Zhao, L., Willmot, M., Gray, L. J., Walker, M. F., …Russell, N. (2006). Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092). Stroke, 37(12), 2979-2983. https://doi.org/10.1161/01.str.0000248763.49831.c3

Background and Purpose - Loss of motor function is common after stroke and leads to significant chronic disability. Stem cells are capable of self-renewal and of differentiating into multiple cell types, including neurones, glia, and vascular cells.... Read More about Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem Cell Trial of Recovery EnhanceMent After Stroke (STEMS) Pilot Randomized, Controlled Trial (ISRCTN 16784092).

Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke (2006)
Journal Article
Gray, L. J., Sprigg, N., Rashid, P., Willmot, M., & Bath, P. M. (2006). Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke. Journal of Stroke and Cerebrovascular Diseases, 15(6),

High blood pressure (BP), pulse pressure (PP), and rate pressure product (RPP) areeach associated independently with a poor outcome in acute ischemic stroke. Whereas nitric oxide (NO) donors, such as glyceryl trinitrate (GTN), lower blood pressure i... Read More about Effect of nitric oxide donors on blood pressure and pulse pressure in acute and subacute stroke.

Clinical outcome after first and recurrent hemorrhage in patients with untreated brain arteriovenous malformation (2006)
Journal Article
Choi, J. H., Mast, H., Sciacca, R. R., Hartmann, A., Khaw, A. V., Mohr, J. P., …Stapf, C. (2006). Clinical outcome after first and recurrent hemorrhage in patients with untreated brain arteriovenous malformation. Stroke, 37(5), 1243-1247

Background and Purpose: The morbidity from spontaneous hemorrhage of untreated brain arteriovenous malformations (AVM) is not well described. Methods: The 241 consecutive AVM patients (mean age 3716 years, 52% women) from the prospective Columbia... Read More about Clinical outcome after first and recurrent hemorrhage in patients with untreated brain arteriovenous malformation.

Significant variation in mortality and functional outcome after acute ischaemic stroke between western countries: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST) (2006)
Journal Article
Gray, L. J., Sprigg, N., Bath, P. M., Sorensen, P., Lindenstrom, E., Boysen, G., …Turpie, A. (2006). Significant variation in mortality and functional outcome after acute ischaemic stroke between western countries: data from the 'Tinzaparin in Acute Ischaemic Stroke Trial' (TAIST). Journal of Neurology, Neurosurgery and Psychiatry, 77,

Compression stockings and the prevention of symptomatic venous thromboembolism: data from the Tinzaparin in Acute Ischaemic Stroke Trial (2005)
Journal Article
Sprigg, N., Gray, L. J., Bath, P. M., Boysen, G., de Deyn, P. P., Leys, D., …van der Sande, J. J. (2005). Compression stockings and the prevention of symptomatic venous thromboembolism: data from the Tinzaparin in Acute Ischaemic Stroke Trial. Journal of Stroke and Cerebrovascular Diseases, 14(5),

Background: Venous thromboembolism (VTE) is a well recognised and preventable complication of acute stroke. While graduated compression stockings reduce the risk of VTE in surgical patients their benefit in acute stroke remains uncertain. Methods: T... Read More about Compression stockings and the prevention of symptomatic venous thromboembolism: data from the Tinzaparin in Acute Ischaemic Stroke Trial.

A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow (2005)
Journal Article
Willmot, M., Gray, L. J., Gibson, C. L., Murphy, S., & Bath, P. M. (2005). A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow. Nitric Oxide: Biology and Chemistry, 12(3),

Background: Nitric oxide (NO) is a candidate treatment for acute ischaemic stroke, however published studies in experimental stroke have given conflicting results. Methods: We performed a systematic review of published controlled studies of L-arginin... Read More about A systematic review of nitric oxide donors and L-arginine in experimental stroke: effects on infarct size and cerebral blood flow.

Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities (2003)
Journal Article
Ulker, S., McKeown, P., & Bayraktutan, U. (2003). Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities. Hypertension, 41,

Antioxidant vitamins C and E have protective properties in genetic hypertension associated with enhanced oxidative stress. This study investigated whether vitamins C and/or E modulate vascular function by regulating enzymatic activities of endothel... Read More about Vitamins Reverse Endothelial Dysfunction Through Regulation of eNOS and NAD(P)H Oxidase Activities.

Two-dimensional NMR of velocity exchange: VEXSY and SERPENT (2001)
Journal Article
Blümich, B., Callaghan, P. T., Damion, R. A., Han, S., Khrapitchev, A. A., Packer, K. J., & Stapf, S. (2001). Two-dimensional NMR of velocity exchange: VEXSY and SERPENT. Journal of Magnetic Resonance, 152(1), 162-167. https://doi.org/10.1006/jmre.2001.2395

Two different multidimensional pulsed field gradient sequences are compared which have the purpose of correlating spin displacements in different time intervals with each other. The simplest possible sequence, three-pulse SERPENT, measures displaceme... Read More about Two-dimensional NMR of velocity exchange: VEXSY and SERPENT.

Pore-scale network modelling of flow propagators derived from pulsed magnetic field gradient spin echo NMR measurements in porous media (2000)
Journal Article
Damion, R. A., Packer, K. J., Sorbie, K. S., & McDougall, S. R. (2000). Pore-scale network modelling of flow propagators derived from pulsed magnetic field gradient spin echo NMR measurements in porous media. Chemical Engineering Science, 55(24), 5981-5998. https://doi.org/10.1016/S0009-2509%2800%2900203-7

Pulsed magnetic field gradient spin echo (PGSE) NMR experiments carried out on porous media where fluid flow is occurring, may be analyzed to give the propagator, P(ξ,t), This quantity is the ensemble density distribution of particle (nuclei) displac... Read More about Pore-scale network modelling of flow propagators derived from pulsed magnetic field gradient spin echo NMR measurements in porous media.

Time Correlations in Fluid Transport Obtained by Sequential Rephasing Gradient Pulses (1999)
Journal Article
Stapf, S., Damion, R. A., & Packer, K. J. (1999). Time Correlations in Fluid Transport Obtained by Sequential Rephasing Gradient Pulses. Journal of Magnetic Resonance, 137(2), 316-323. https://doi.org/10.1006/jmre.1998.1685

We present a basic experiment by which the evolution of the displacement probability density (propagator) of static or flowing fluid in N successive time intervals is obtained by single labeling, coupled with multiple rephasing events during the cour... Read More about Time Correlations in Fluid Transport Obtained by Sequential Rephasing Gradient Pulses.